Scientists have used artificial intelligence to “predict” formulas for new designer drugs, with the stated goal of helping to improve their regulation. The AI generated formulas for nearly nine million potential new drugs.

Researchers with the University of British Columbia (UBC) used a deep neural net for the job, teaching it to make up chemical structures of potential new drugs. According to their study, released this week, the computer intelligence fared better at the task than the scientists had expected.

The research team used a database of known designer drugs – synthetic psychoactive substances – to train the AI on their structures. The market for designer drugs is ever-changing, since their manufacturers are constantly tweaking their formulas to circumvent restrictions and produce new “legal” substances, while cracking their structure takes months for law enforcement agencies, the researchers said.

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“The vast majority of these designer drugs have never been tested in humans and are completely unregulated. They are a major public-health concern to emergency departments across the world,” one of the researchers, UBC medical student Dr. Michael Skinnider has said.

After its training, the AI was able to generate some 8.9 million potential designer drugs. Afterwards, researchers ran a data sheet of some 196 new drugs, which had emerged in real life after the model was trained, and found that more than 90% of these have been already predicted by the computer.

“The fact that we can predict what designer drugs are likely to emerge on the market before they actually appear is a bit like the 2002 sci-fi movie, Minority Report, where foreknowledge about criminal activities about to take place helped significantly reduce crime in a future world,” senior author Dr. David Wishart, a professor of computing science at the University of Alberta, has said.

Identifying completely unknown substances remains an issue for the AI, the research team has noted, but they hope it might potentially help with that task, since the computer was also able to predict which formulas of designer drugs were more likely to be created and hit the market. The model “ranked the correct chemical structure of an unidentified designer drug among the top 10 candidates 72 percent of the time,” while throwing in spectrometry analysis, which is an easily obtained measurement, bumped the accuracy to some 86%.

“It was shocking to us that the model performed this well, because elucidating entire chemical structures from just an accurate mass measurement is generally thought to be an unsolvable problem,” Skinnider stated.

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Hospitals in the Netherlands have begun delaying certain operations to free-up ICU beds during a record wave of Covid-19 infections, while an infectious diseases researcher has warned of an impending ‘Code Black’ in the sector.

The country set a daily national record for new Covid infections on Thursday, registering around 23,600 cases. It was the third day in a row of the figure topping 20,000.

To make more staff available for Covid wards, a number of operations, including those for cancer and heart patients, are being canceled from this week on, Dutch healthcare officials have said. Fewer than 200 beds remained available in Dutch ICUs as of Thursday, while Friday figures show almost half (47.8%) of occupied ICU beds were being used by Covid patients.

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FILE PHOTO. A woman wearing a protective mask walks past a store in Amsterdam, Netherlands.
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“These are cancer patients that should actually be operated-on within six weeks of diagnosis, and that won’t be met in all cases. It’s also heart patients,” said a spokesperson for the National Coordination Center for Patient Distribution (LCPS).

Meanwhile, new calculations by an infectious disease modeller at Wageningen University & Research suggest that a so-called ‘Code Black’ in hospitals is looming. The emergency designation means that patient safety is at risk and, if declared, would mean many people with life-threatening illnesses cannot go to the ICU, while doctors have to prioritize who to treat.

According to recent estimates from the Dutch Healthcare Authority (NZa), up to 200,000 operations were not performed as a result of urgently needed Covid care since the start of the pandemic. On Thursday, the NZa revealed that almost a quarter of operating rooms across the country are not currently in use due to a combination of Covid patient pressures and rising staff absences due to illness.

It is not yet clear what impact the delayed care will have on public health. In December 2020, the Dutch National Institute for Public Health and the Environment (RIVM) calculated that an estimated 34,000 to 50,000 ‘healthy life years’ had been lost due to the first Covid-19 wave alone.

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Protests against renewed Covid-19 restrictions turned violent in The Hague. The unrest comes a day after several demonstrators in another Dutch city, Rotterdam, were injured amid police gunfire.

Seven people were arrested after fierce clashes broke out between law enforcement and anti-lockdown demonstrators in The Hague, the seat of the International Court of Justice (ICJ), on Saturday.

A video shared on social media shows protesters lighting firecrackers that sparked multiple fires, causing the skies in the city to glow an eerie red.

In another clip, a group of protesters could be seen knocking down a traffic pole fitted with a surveillance camera.

Dutch police reported that five of its officers were injured in the showdown with rioters. One officer was taken to hospital with a knee injury and concussion. Two others “suffered hearing damage,” while another two suffered injuries to their hands.

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A burned electric scooter is seen after an anti-lockdown protest in Rotterdam, Netherlands, November 19, 2021 © AFP / Jeffrey Groeneweg
Lockdown protest described as ‘orgy of violence’

The chaotic scenes in the Netherlands’ third-largest city unfolded a day after a protest against reimposed Covid-19 restrictions in Rotterdam was marred by violence. Over 50 people were arrested in the city and three were injured after police opened fire in a bid to quell the unrest. Police later claimed that officers were “compelled to shoot at targets” to protect themselves. The three injured protesters remain in hospital, and their condition is unknown.

Protests have swept through a number of Dutch cities after the Netherlands became the first country in Western Europe since summer to go into a partial lockdown last week. Tensions soared further after the government banned New Year’s Eve fireworks displays and the Dutch parliament backed the introduction of the so-called 2G system, which would bar the unvaccinated and those who have not recently recovered from the virus from a long list of public places if introduced.

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As information emerges about Islamic State of Khorasan, or ISIS-K – the terrorist group that claimed responsibility for last week’s suicide attack that killed 13 US service members and more than 160 Afghans – there is an increased effort to predict how Afghanistan, under Taliban rule, may emerge once again as a breeding ground for terrorist groups.

A United Nations report released in June estimates that thousands of fighters from the region had already poured into Afghanistan.  Many of them are believed to be affiliated with either the Taliban – still seen as a terrorist organization – or al Qaeda or ISIS-K.

The New York Times reports that ISIS-K was created six years ago by members of the Pakistani branch of the Taliban.  There is a range of thought among experts as to what their ability to successfully carry out a terrorist attack in a Taliban-ruled area means for the terrorist threat moving forward. 

The Cipher Brief spoke with respected terrorism experts Bruce Hoffman, Mitch Silber and Colin Clarke to get their thoughts on the current risk of terrorist attacks against Americans both home and abroad. 

Bruce Hoffman, Terrorism Expert and Professor, Georgetown University

Cipher Brief Expert Bruce Hoffman is a professor at Georgetown University and served as a commissioner on the Independent Commission to Review the FBI’s Post-9/11 Response to Terrorism and Radicalization.  He is also a Scholar-in-Residence for Counterterrorism at CIA.

Mitch Silber, Former Director of Analysis, NYPD

Cipher Brief Expert Mitch Silber served as Director of Intelligence Analysis at the New York City Police Department and served as principal advisor to the Deputy Commissioner of Intelligence on counterterrorism policy and analysis. He is now executive director of the Community Security Initiative.

Colin Clarke, Director of Policy and Research, The Soufan Group

Colin P. Clarke, Ph.D., is the Director of Policy and Research at The Soufan Group. Clarke’s research focuses on domestic and transnational terrorism, international security, and geopolitics. He is also a senior research fellow at The Soufan Center.  

The Cipher Brief: If the United Nations Report issued in June is accurate, and there are thousands of fighters from the region who have poured into Afghanistan – many associated with known terrorist groups – is there any way that the administration can say ‘mission accomplished’ in terms of degrading terrorism’s presence in Afghanistan? 

Hoffman: No. As those numbers from the report released by the United Nations Support and Sanctions Monitoring Team highlight, Afghanistan is again becoming a jihadi magnet and will likely continue to be so into the future. The suicide bomb attacks outside the gates of Kabul International Airport last Thursday underscore the multiplicity of terrorist groups already present in that country.

In addition to ISIS-K, there is the Haqqani Network, al Qaeda and, of course, the Taliban. Terrorism thrives in conditions of chaos and instability which the terrorists hope to spread to other countries and eventually across regions.

Much as Salafi-Jihadi terrorists migrated from existing battlefields in South Asia back to the Middle East, North Africa, and the Caucasus in the 1990s; spread to East and West Africa in the early 2000s; blossomed during the Arab Spring to wage civil wars in Syria, Libya, and the Sahel, in the early twenty-teens; the same phenomenon is unfolding in Afghanistan.

Silber:  Frankly, I don’t think any of the four administrations can make the claim that the policy goal of making Afghanistan inhospitable to serve as a safe haven for Al Qaeda or other similarly oriented jihadist groups has been accomplished.  Certainly, at a number of times during the last twenty years, the threat that jihadist groups, most importantly — Al Qaeda — has presented, in terms of their ability to project a threat to the United States has been diminished, the degradation of the threat was only temporary.

The Cipher Brief: How confident are you that Al Qaeda and ISIS are unable to plan and execute attacks against the U.S. domestically? 

Hoffman:  The credulous Doha negotiations with the Taliban that led to the withdrawal of U.S. military forces from Afghanistan and subsequently to the Taliban’s blitzkrieg across Afghanistan and then to the shambolic evacuation of our diplomats and citizens, has painted a huge target on America’s back. Like sharks in the water, terrorists will smell blood. As my Council on Foreign Relations colleague, Jacob Ware, and I wrote in War on the Rocks, in May, every time terrorism has forced the U.S. to withdraw from a conflict zone where it had committed ground forces, whether in Lebanon in 1984; Somalia in 1993; and Iraq in 2011, it has led to more terrorism worldwide, not less, and thus made the U.S. less safe.

At a time when our country continues to grapple with the COVID pandemic; when climate change is pulverizing the Gulf States with Hurricane Ida and California with worsening wildfires; when the January 6th insurrection at the U.S. Capitol building continues to smolder with incidents such as the bomb threat that paralyzed the area near the Library of Congress and Cannon House Office Building earlier this month; coupled with ongoing cyberattacks and peer competition from China and Russia and concerns over Iran’s nuclear aspirations; our terrorist adversaries may well conclude that the U.S. is sufficiently preoccupied or distracted by any or all of the preceding and therefore conclude that the time to strike the homeland is opportune. It would very unlikely entail a repeat of the catastrophic September 11th 2001 attacks. But a terrorist strike along the lines of the 2019 shootings at Naval Air Station Pensacola; the 2017 suicide bombing of a concert venue in Manchester, England; the coordinated suicide attacks on London transport in 2005; the 2004 Madrid commuter train bombings; or any kind of significant lone wolf incident perpetrated in the name of some existing terrorist movement would likely re-create the widespread fear and anxiety that are terrorism’s stock-in-trade. Twice in the past three years, it should also be noted, members of al-Shabaab – perhaps al Qaeda’s least technologically proficient franchise – have been arrested both in the Philippines and in an undisclosed African country engaging in the same flight training that four of the 9/11 hijackers undertook before their fateful, history-changing coordinated attack.

Silber:  At this very moment, it is unlikely that Al Qaeda or ISIS-K have the infrastructure, resources, recruits and external planning ability to strike the United States based on statements by the IC and senior DoD officials to Congress.  However, without any, or only limited external pressure by the U.S. military as a result of the retreat from Afghanistan, these networks and capabilities can be reconstituted in the coming months and certainly groups like Al Qaeda have never given up their desire to strike the American homeland.

Clarke:  I think it is unlikely that AQ or ISIS will be able to attack the U.S. homeland.  We’ve spent the better part of the past two decades shoring up homeland defense. We’ve got CT tools now that we didn’t have twenty years ago. That said, the picture could look quite different 6, 12, 18 months from now. Both of those organizations are capable of regenerating an external operations planning capability. There is also the worry of inspired attacks.


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The Cipher Brief:  Some analysts have said that morale among terrorist or Islamic extremist groups is extremely high due to the circumstances surrounding the US pullout in Afghanistan, do you agree and if so what does that mean? 

Hoffman:  Yes. Of course. Both Sunni and Shi’a terrorist movements around the globe have applauded the Taliban’s re-conquest of Afghanistan and routing of the U.S. military. For Sunni Salafi-Jihadi terrorists, the events there this past month validate the strategy articulated by Usama bin Laden just before the 2004 U.S. presidential election, when he described the ease with which al-Qaeda had been able to “bled Russia for 10 years, until it went bankrupt and was forced to withdraw in defeat” from Afghanistan in 1989, and predicted that the same fate would eventually befall the U.S. And, Sayed Hassan Nasrallah, the Secretary-General of Hezbollah, a Shi’a terrorist organization, for instance, last week delivered a sermon where he described America’s “historic and humiliating defeat in Afghanistan as representing, “the moral downfall of America.”

Silber:  Jihadi chat rooms and online extremist networks are feeling like they have the wind behind them.  It took twenty years, but before the 20th anniversary of the attacks of 9/11 an Islamic emirate has been re-established in Afghanistan.  Suddenly, what seemed impossible has become possible and Islamist insurgencies all throughout the Middle East and South Asia can take inspiration by the determination of the Taliban in their efforts to overthrow a secular democratic government and replace it with an Islamist one.

Clarke:  I do expect morale to be high among terrorist and especially Islamic extremists given the turn of events we’ve seen in Afghanistan. We’re a week and a half out from the 20-year anniversary of 9/11, and Al Qaeda leaders are returning to Afghanistan (this is being displayed in AQ propaganda). We’ve seen al-Qaeda affiliates all over the globe congratulating the Taliban for their victory. I don’t want to overstate the case here, but I do believe that what has occurred in Afghanistan will be a serious boost for the global jihadist movement right at the same time the U.S. and its allies are shifting from counterterrorism to great power competition. There will be fewer resources and energy to deal with terrorists, right at the time we have major threats metastasizing in Afghanistan, potentially with both a reinvigorated al-Qaeda and a stubbornly resilient ISKP.

Read also Mike Leiter’s Why We’re Much Safer from Terrorism Now, Than We Were After 9/11 in The Cipher Brief 

Read also Why We Need a New National Defense Strategy (for terrorism) exclusively in The Cipher Brief 


Go beyond the headlines with expert perspectives on today’s news with The Cipher Brief’s Daily Open-Source Podcast.  Listen here or wherever you listen to podcasts.


 

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The city council in Austria’s second-largest city, Graz, has elected a new mayor. Communist Party member Elke Kahr has become the first Communist leader of a major city in the country.

The 60-year-old politician, who has been working in the municipal government for more than 15 years and previously served as vice mayor of Graz, was elected as the new city leader on Wednesday. A member of the Austrian Communist Party (KPÖ, Kommunistische Partei Österreichs) for almost 30 years, she won the election with 28 of 46 votes. Kahr succeeded the previous long-standing mayor Siegfried Nagl of the center-right, liberal-conservative People’s Party.

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Who would have thought that the daughter of a locksmith, a Communist, would become mayor,” she said in her first speech following the vote.

Having acknowledged a number of issues to deal with in the city, especially during the Covid-19 pandemic, the new mayor highlighted a housing policy, pledging to put a stop to profit-driven construction in Ganz.

The Communists have also already formed a coalition with the Greens and the Social Democratic Party (SPÖ), and another precedent in European city governance was made – two women serving as mayor and deputy. Green leader Judith Schwentner was chosen as Graz’s vice mayor, with the new governing coalition saying they would support not only social, but also environmental changes, aiming to improve living standards especially for low-income groups. Providing a bicycle for every child in the city from the municipality is in their program.

However, not everyone in the local government is happy with the new Communist rule. A member of the right-wing Freedom Party of Austria (FPÖ), Alexis Pascuttini, described the choice as “unpleasant,” having accused the Graz Communists of empty catchphrases in their program and refusing to participate in what he described as “left-wing nonsense.” Kahr herself has been exposed to strong pressure to justify her party, being repeatedly asked about her position on “the crimes of communist parties around the world since 1917,” according to Austrian media.

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Austria will introduce a full lockdown that could last for three weeks on Monday in an attempt to tackle a new wave of Covid-19 infections. The government has also ordered the entire population to get vaccinated from February 1.

On Friday, conservative Chancellor Alexander Schallenberg told a news conference that a complete lockdown of the nation would begin on Monday and last for an initial 10 days.

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French President Emmanuel Macron (FILE PHOTO) © REUTERS/Sarah Meyssonnier
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He stated that the restrictions could be extended if infection rates did not start to fall, but he insisted the lockdown would not exceed 20 days.

The measures concern the entire Austrian population. The government has already imposed a partial lockdown on the unvaccinated in an effort to reduce hospitalization rates amid a surge in Covid-19 cases.

When the full lockdown ends, restrictions will remain in place for the unvaccinated.

Schallenberg’s announcement came after a meeting of nine state governors, two of whom had already vowed to introduce full lockdowns in their regions on Monday, in the western province of Tyrol.

The chancellor also announced that vaccinations would be mandatory from February 1. “We haven’t been able to convince enough people to vaccinate. For too long, I and others have assumed that you can convince people to get vaccinated,” he added, giving his rationale for the mandate.

Schallenberg said he lamented the political forces, radical opposition, and fake news fighting against vaccination.

Austria has one of the lowest vaccination rates in western Europe, with only 65% inoculated against the deadly virus according to data from Johns Hopkins university.

Infection rates are almost among the highest on the continent. The seven-day incidence rate stands at 971.5 per 100,000 people.

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Denmark’s air force showed off its brand-new electric-powered planes on Thursday, saying its test flights have so far proven that the cheaper-to-run, more eco-friendly technology has potential.

It had obtained the two Velis Electro jets from Slovenian manufacturer Pipistrel, becoming the first military in the world to operate this type of hardware.

“The aircraft are 100% emission-free, very quiet, and otherwise cheap to operate,” Lieutenant Colonel Casper Børge Nielsen of the Defense Ministry’s material and procurement agency said. Initial tests indicate “there may be perspectives in using electric aircraft when the technology becomes mature,” he added.

Denmark has leased the planes for two years, rather than buying it, to avoid the “risk of ending up with equipment that we can’t really use,” Børge Nielsen said. During the lease period, the Danish Air Force hopes to gain an insight into the benefits and disadvantages of the jets’ technology to decide how it can be applied in the future.

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© CIAM / Facebook
Russia to debut world’s first electric plane at MAKS 2021 airshow

The pilots described flying the one-man light electric planes, which are powered by two lithium batteries, as “exciting,” saying they were “built well and fly well.” 

Last year, the United States military said it had been keeping an eye on the development of electric-powered planes, describing their ability to approach targets silently as “tremendous.” However, their battery capacity isn’t currently sufficient to meet the US Air Force’s needs.

Work on electric aircraft has been underway since the 1970s, but the battery issue has been a stumbling block in the way of wider adoption of the technology. Global military interest could change all that, stimulating research and investment.

The switch to electric power is likely to be a win-win across the board, as it will drastically reduce CO2 emissions and also make flying much cheaper for commercial carriers and their passengers.

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Scientists in Sweden claim that a single protein in the blood could predict the onset of Type 2 diabetes nearly 20 years in advance. The breakthrough potentially affects hundreds of millions of people worldwide.

Diabetes is the world’s ninth-leading cause of death, and affects nearly half a billion people worldwide, according to the World Health Organisation (WHO). The vast majority of diabetes patients suffer from Type 2 diabetes, a condition that can lead to blindness, kidney failure, heart attacks, strokes, and lower limb amputation. Cases of diabetes quadrupled worldwide between 1980 and 2014, with unhealthy diets and lack of exercise blamed for the rise.

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© Getty Images / Peter Dazeley
NHS setting up fat camps for children

However, researchers at Lund University in Malmo, Sweden claim that elevated levels of a certain protein – follistatin – in the blood can predict the onset of Type 2 diabetes regardless of a person’s age, weight, diet or activity level. In a study published last week, the scientists wrote that high levels of follistatin can predict the condition up to 19 years before symptoms appear.

To discover the link between follistatin and diabetes, the researchers tracked 5,300 people from Sweden, Italy, and the UK for between four and 19 years. Follistatin helps break down body fat, while simultaneously leading to an increase in fat in the liver. This buildup can cause fatty liver disease and Type 2 diabetes.

“This study shows that follistatin has the potential to become an important biomarker to predict future Type 2 diabetes, and it also brings us one step closer to the understanding of the mechanisms behind the disease,” Dr. Yang De Marinis, associate professor at Lund University and lead author of the study, told a university newsletter. De Marinis added that the next step for her team would be to help develop an AI-based diagnostic tool that could analyze a patient’s blood sample and use their follistatin levels – and other biomarkers – to calculate their “risk score” for Type 2 diabetes.

As follistatin levels rise in response to food intake and activity levels, the same advice for prevention of diabetes still applies. “Balanced meals, eat[ing] healthy and regular exercise are important to decrease the risk of developing Type 2 diabetes,” De Marinis told StudyFinds.

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Australia’s Defense Minister derided a senior Chinese diplomat’s comments as “silly” and “comical,” after the latter dubbed Canberra’s trilateral nuclear-powered submarine pact with the US and UK a threat to peace.

During a television interview on Friday, Peter Dutton said acting Chinese Ambassador Wang Xining was “probably reading off a script from the Communist Party” when he warned that Australia would become the “naughty guy” if it procured the stealth-combat vessels through the AUKUS deal.

Wang, who is China’s most senior representative to the country after the previous ambassador’s term ended last month, told The Guardian on Thursday that Australia would be labeled a “sabre-wielder” rather than a “peace defender.” He said the Australian public “should be more worried” about the impact of the security pact their nation had made with the UK and the US. 

There’s zero nuclear capacity, technologically, in Australia, that would guarantee you will be trouble free, that you will be incident free. And if anything happened, are the politicians ready to say sorry to people in Melbourne and in Adelaide?

However, Dutton “dismissed” the comments and countered that “most Australians [would] see through [their] non-productive nature.”

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“We don’t see it from any other ambassador here in Australia. It’s quite remarkable,” the minister told the Nine Network, adding that “this type of diplomacy” was seen elsewhere in the world too.

“These provocative comical statements – it’s just so silly. It’s funny,” he added.

In September, Australian Prime Minister Scott Morrison announced the deal to obtain at least eight nuclear-powered vessels as part of its new defense alliance. The pact angered not only China but also France, which claimed it had been “stabbed in the back” after Canberra unilaterally scrapped a multi-billion-dollar diesel-electric submarine contract with Paris.

Last weekend, Dutton had irked Beijing by stating that he could not conceive of a situation in which Australia would hesitate to support the US should armed conflict with China break out over Taiwan. Under its ‘One China’ policy, Beijing has pledged to reunify the island with the mainland.

Wang warned Australian politicians on Thursday not to do anything that would be “destructive to our relationship.”

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Hard-line cleric Ebrahim Raisi won Iran’s presidential election on Saturday in a move that is expected to bolster the conservative legacy of the country’s supreme leader, Ayatollah Ali Khamenei.

The decision is not expected to derail ongoing negotiations aimed at restoring the Joint Comprehensive Plan of Action (JCPOA) nuclear deal, even though Mr. Raisi himself is under US sanctions over accusations of human rights abuses.  Many voters stayed away from the polls as the outcome had been predicted for months with many progressive candidates barred from running.

The Islamic Republic has entered a post-revolutionary dynamic in which a fading revolutionary generation seeks to ensure that the rising political leadership sustains their revolutionary ideals,” says Norman T. Roule, former National Intelligence Manager for Iran at ODNI and Cipher Brief Expert. “The regime’s decision to bar so many candidates and the low turnout make this election a historic embarrassment for the regime and its supporters.”

The Cipher Brief talked with Roule about what the election means and what it doesn’t mean when it comes to relations with the west, the progressive movement within Iran and the election’s impact on the oil markets.


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