The EU’s drug regulator has backed the emergency use of Merck’s pill for the treatment for clinically vulnerable Covid-19 patients as cases surge across the continent.

On Friday, the European Medicines Agency (EMA) “issued advice” backing the emergency use of the drug developed by Merck in collaboration with Ridgeback Biotherapeutics, although it has not yet been authorized by national authorities.

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© Reuters / Piroschka van de Wouw
EMA green lights new Covid treatments

In a statement, the drug regulator said the medicine called Lagevrio – also known as molnupiravir or MK 4482 – “can be used to treat adults with Covid-19 who do not require supplemental oxygen and who are at increased risk of developing severe Covid-19.

It said the treatment should be administered as soon as possible after Covid-19 is diagnosed and within five days of the start of symptoms. The medicine should be taken twice a day for a period of five days.

The EMA listed the potential side effects of the capsules, including mild or moderate diarrhea, nausea, dizziness and headache. The treatment is not recommended for pregnant women.

The watchdog announced earlier on Friday that it had begun reviewing Pfizer’s medicine Paxlovid for Covid-19 with the same goal “to support national authorities” who may decide on its early use prior to marketing authorization in light of rising cases and deaths in Europe.

On Friday, Austria announced it would enter a new nationwide lockdown from Monday and make vaccination mandatory, while Germany’s health authorities claimed the country had turned into “one big outbreak.”

Both Pfizer and Merck have requested approval for their coronavirus medicines from the US Food and Drug Administration, but it is unclear when it might be granted.

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Truckers and other motorists have been trapped in a four-mile-long traffic jam on the outskirts of the Dutch city of Rotterdam amid a protest against the government’s Covid measures.

According to local media, as many as 200 activists blocked the gates of a major port in the city’s harbor on Thursday. For several hours, they prevented any vehicles from driving in and out of the cargo hub, which, in turn, led to massive traffic congestion on the highway leading to the port. Police engaged in negotiations with the protesters, who eventually relented and left the site later in the evening.

The group behind the protest action is reportedly Dockers United, who are staunchly opposed to government Covid policies. The organization’s biggest concern is that authorities could soon make it mandatory for employees to have a vaccination or recovery certificate to enter the workplace, which, as the group argues, would be tantamount to excluding people from society on an “unconstitutional basis.” They are also generally unhappy with the curbs introduced by the Dutch government, with ‘Don’t normalize what’s not normal’ being a translation of one of their slogans.

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Riot police officers face protesters in the Hague on November 12, 2021, as the PM announced new Covid-19 restrictions © Jeroen Jumelet / ANP / AFP
WATCH: Protesters, police clash after new Covid restrictions announced in the Netherlands

In fact, the Dutch government did announce earlier this month that it was working on introducing a ‘corona pass’ for the workplace, though it isn’t clear yet when this measure will be rolled out and how strict it will be.

Meanwhile, on Friday the EU country logged its highest-ever number of new Covid cases within 24 hours, with that figure reaching 23,591. Medics say they are working at capacity.

Amid the spike, the Dutch prime minister imposed a partial lockdown last Saturday, which requires bars, restaurants, cafes and supermarkets to close at 8pm, while shops selling non-essential goods are to shut by 6pm. Public gatherings are banned altogether.

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A cleaner for Israel’s defense minister has been accused of espionage after allegedly offering to place malware on his boss’ household computer for an Iran-linked hacking group.

In a statement on Thursday, the Shin Bet security service said that Omri Goren, a housekeeper for Defense Minister Benny Gantz, and a former bank robber according to Israeli media, corresponded with an unnamed person over social media shortly before his arrest. 

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American Businessman Bill Gates (FILE PHOTO) © Jeff J Mitchell/Pool via REUTERS
Bill Gates predicts Covid-19 mortality rate

Goren reached out earlier this month to “a figure affiliated with Iran and offered to help him in different ways, in light of his access to the minister’s home,” the statement read, according to the Times of Israel.

It is understood that Goren offered to spy and place malware on Gantz’s computer on behalf of a hacking group, reportedly called ‘Black Shadow’ and associated with Iran, Tel Aviv’s perennial enemy. It is also said that he provided photos of Gantz’s residence to prove he had access. 

A Central District prosecutor filed espionage charges against Goren on Thursday. If convicted, the accused could face a sentence of between 10 and 15 years, according to the Times of Israel.

The 37-year-old Lod resident has previously served four prison sentences, the most recent of which was for four years. Goren was found guilty of five crimes between 2002 to 2013, two of the convictions were for bank robbery.

The Shin Bet said they would review their processes for staff background checks “with the goal of limiting the possibility of cases like this repeating themselves in the future.”

Speaking on Kan public radio, Gal Wolf, the attorney representing Goren, suggested his client had intended to extract money from the Iranians without carrying out any spying.

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Kids say the strangest and funniest things. We’ve always loved the frank, honest and unadulterated way that little humans choose to express themselves. They see things from a different perspective to us grownups whose thoughts have been shaped and molded by the world around us. NYC school teacher Alyssa Cowit was so fascinated by the questions and comments from her Kindergarteners that she decided to start an Instagram account, called Live From Snack Time, to chronicle them. Scroll down for some of the best ones!

Kids say the funniest things!

Kids say the funniest things!

Kids say the funniest things!

Kids say the funniest things!

Kids say the funniest things!

Kids say the funniest things!

Kids say the funniest things!

Kids say the funniest things!

Kids say the funniest things!

Kids say the funniest things!

Kids say the funniest things!

Kids say the funniest things!

Kids say the funniest things!

Kids say the funniest things!

Kids say the funniest things!

Kids say the funniest things!

Kids say the funniest things!

Kids say the funniest things!

Kids say the funniest things!

Kids say the funniest things!

Kids say the funniest things!

Kids say the funniest things!

Kids say the funniest things!

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Mark Kelton, Former Deputy Director, CIA’s Counterintelligence, National Clandestine Service

Cipher Brief Expert Mark Kelton is a retired senior Central Intelligence Agency executive with 34 years of experience in intelligence operations. Before retiring, he served as CIA’s Deputy Director for Counterintelligence.  He is a partner at the FiveEyes Group and is Board Chair of Spookstock, a charity that benefits the CIA Memorial Foundation, the Special Operations Warrior Foundation and the Defense Intelligence Memorial Foundation.

EXPERT PERSPECTIVE — Winston Churchill’s 04 June 1940 speech in which he vowed that he and his countrymen would “fight on the beaches “and would “never surrender” in the face of a seemingly inevitable Nazi invasion is rightly renowned as perhaps history’s most famous address by a wartime leader.  Less well known, however, is the cautionary tone the new Prime Minister struck in that same appearance before the House of Commons, as he sought to temper the joy and relief engendered by the seemingly miraculous extraction of the British army from the beaches of Dunkirk.  “We must,” Churchill warned, “be very careful not to assign to this deliverance the attributes of a victory.”  “Wars” he admonished, “are not won by evacuations.”

Shortly before the 2011 Abbottabad operation that killed Osama bin Laden, I was asked by my HQ, my views on mounting an assault on the target we knew as Abbottabad Compound 1, (AC1) given that we were not sure it sheltered the terrorist leader.  After expressing my 95% confidence that the Al Qaeda (AQ) leader was in fact, there, I allegorically added that we must strike as ‘you cannot leave Hitler in his bunker and end the war’.  I was fortuitously, right in my assessment that the murderer of so many innocents was present within AC1.  Sadly, however, his death did not bring our war with radical Islamic terrorism to a conclusion.  As was the case after Dunkirk, our enemy was unwilling to quit the field or to limit his unbounded war aims.

Likewise, we should have no expectation that the withdrawal of our forces from the Afghan theater of combat signals an end to the conflict with terrorists who started that war by attacking us on September 11, 2001.  We cannot unilaterally declare an end to the War on Terror by leaving Afghanistan – however much we might wish to do so – for the very simple reason that our enemies do not share that desire.  As former Defense Secretary Leon E. Panetta put it, “I understand that we’re trying to get our troops out of there, but the bottom line is, we can leave a battlefield, but we can’t leave the war on terrorism, which still is a threat to our security.”

The Taliban parading of the American-made weapons and accoutrements of their defeated foes was, in a manner akin to that of ancient Rome, intended not only to celebrate victory.  It was also meant to humiliate the vanquished.   Such triumphal demonstrations – and what will be a galling celebration of the anniversary of 9/11 as their own holiday to follow – will evoke enthusiastic responses from Islamic extremists and will draw many new adherents to the cause that lies at the core of Taliban legitimacy and belief.

As was the case when we left Iraq and later had to go back into the region to crush the ISIS Caliphate that metastasized in the wake of our departure, there is every prospect that the Taliban’s success will breathe new life into Islamic extremist groups.  And there is no reason to believe that the “new” and now much more heavily armed Taliban – an organization that refused to break with AQ over the course of a brutal twenty-year battle, will be any less receptive to working with Islamic terror groups than were their pre-9/11 forebears.


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“We are going to have to maintain very, very intense  levels of indicators and warnings and observstion and ISR [Intelligence, Surveillance, Reconnaissance] over that entire region to monitor potential terrorist threats”, said Chairman of the Joint Chiefs, General Mark Milley in a recent interview, adding it will not be easy.

As CIA Director William Burns said during Senate testimony in April, “Our ability to keep (the) threat…in check in Afghanistan from either al Qaeda or ISIS…has benefited greatly from the presence of U.S. and coalition militaries on the ground and in the air fueled by intelligence provided by the CIA and our other intelligence partners.” With the withdrawal of the American military, Burns said, “the U.S. government’s ability to collect and act on threats will diminish.”

Much discussed ‘over the horizon’ intelligence collection against Afghan terror targets will not fill the void left by the loss of our ability to monitor and attack terrorist targets from in-country bases.  With Afghanistan bordered by countries unlikely to be willing to host a significant US presence, intelligence collection missions will now have to be launched from bases well beyond the horizon with all that implies for the quantity, quality and timeliness of intelligence collected.  Such operations will also be commensurately more expensive and difficult to mount.  Moreover, the intimate knowledge of our adversaries that we have painstakingly built over the course of nearly 20 years on the ground, began aging the moment we departed Afghanistan.  Absent an intelligence presence on the ground, our ability to collect on terrorist groups operating in and from that country will only degrade further as time goes on.

After acknowledging that we “could see a resurgence of terrorism out of the region in the coming 12-36 months”, Milley went on that we will, “as opportunities present themselves… have to continue to conduct strike operations if there’s a threat to the United States.”  However, as our pre-9/11 experience showed, such remote strikes can delay our terrorist enemies’ plans, but will not deter them from their intent to strike the US homeland.

As such, Secretary Panetta is undoubtedly correct in his conclusion that US involvement in Afghanistan is not over.  “We’re going to have to go back in to get ISIS,” Panetta said.  “We’re probably going to have to go back in when al-Qaeda resurrects itself, as they will, with this Taliban.”  And, as was the case with our operations to destroy ISIS’s so-called Caliphate after we precipitously left Iraq, there can be no doubt that should we have to go back into Afghanistan, our task will be greatly complicated by the manner in which we left that country, abandoning our allies and bases there.


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The US withdrawal from Afghanistan will have profound geo-strategic implications for America’s position in the region and in the world.  Our Chinese, Russian and Iranian adversaries will seize the opportunity to fill the void left in the wake of our departure.

The Taliban has already indicated it will engage with China, which covets Afghanistan’s mineral wealth.  Entry into a transactional relationship with the cash-strapped Taliban regime and granting access to Afghan mineral resources – and possibly use of Bagram Air Base – in exchange for financial aid and Chinese support for the Taliban in international organizations would suit Beijing, which would evince no concerns about human rights and the like.

For their part, Central Asian countries will look away from Washington and ever more towards their old masters in Moscow and a rising China to ensure their security and economic well-being.   Islamabad, while publicly celebrating the victory of their Taliban proxies and its role in guiding it, must at the same time worry that the extremism embodied by the victors will gain renewed traction beyond its frontier provinces with all that implies for the security of the Pakistani state.

Caught by surprise by Washington’s decision to leave and the conduct of the withdrawal, even our closest and oldest allies are questioning US resolve.  They will surely think twice before acceding to any future US request to join in joint operations.  Our decision to quit Afghanistan, and its messy execution, will also evoke questions about the validity of American assurances to other nations under threat from aggressors.  It will not have been lost on them that the withdrawal of American air, intelligence, planning expertise and logistical support ensured the collapse of an Afghan Army that was dependent on the US.

Our adversaries, too, will see the chaotic nature of our departure as well as the abandonment of Americans, allied citizens and Afghans to uncertain fates as signs of weakness and enfeeblement.   This possibility is particularly dangerous in that they could seize this moment of US distraction to engage in opportunistic adventurism that could include movement by China against Taiwan; a Russian attempt to resolve its impasse with Ukraine forcibly; stepped-up Iranian prosecution of its proxy war with Israel; or a further ramping up by North Korea of its nuclear program.  Any such eventuality would force the US to respond vigorously or risk further erosion of its international credibility.

Finally, the costs involved in remotely monitoring and trying to deter threats emanating from a Taliban-controlled Afghanistan mean that we will be unable to shift intelligence and military resources away from the War on Terror to confront the threat posed by peer competitors to the degree we had hoped.

Aristotle is said to have pronounced, “You will never do anything in this world without courage. It is the greatest quality of the mind next to honor.”  Likewise, the courage shown by so many – and the heroic conduct of US military and CIA personnel in particular – in seeking to extract American citizens from Afghanistan and to honor our obligations to Afghans who worked and fought alongside us for so long, cannot obviate the dishonor attendant to having left so many behind.  Bloody Taliban outrages and reprisals against the latter are a certainty.

It will not be long before Kabul’s new rulers recognize that the Americans now under their control, are potentially useful pawns in trying to extract diplomatic, financial and other concessions in exchange for their freedom.  The effectiveness of our efforts hereafter to extract our own people and our Afghan allies from the clutches of the Taliban and how we respond to any attempts to use them as leverage against us, will determine the depth of the stain on our national honor already attendant to the disastrous end of our Afghan campaign.

In that same famous speech, Churchill solemnly told his countrymen that: ‘The Battle of France is over: The Battle of Britain is about to begin.”  He went on that “we would be well advised to gird our loins for the continued warfare to come.”

As we approach the 20th anniversary of 9/11, we should honor our sacred dead from that horrible day.  But we should likewise prepare ourselves for the battles with Al Qaeda and its murderous kindred of Cain that will surely come.

Recent polls would indicate that Americans support the decision to withdraw from Afghanistan, if not the way in which it was conducted.  One wonders how those polled would have responded if the question had been ‘Do you support a withdrawal from Afghanistan even if it markedly increases the chance of terror attacks and atrocities directed at your fellow citizens at home and abroad?’  I fear we will find out soon enough.

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EXPERT PERSPECTIVE — On 16 June, US President Joe Biden and Russian President Vladimir Putin met for just under four hours in Geneva. This was Mr. Biden’s first meeting with Mr. Putin during his presidency and Biden is the fifth US President with whom Putin has held a summit.

Expectations for the summit were characterized as low by both sides in advance and assessed a bit more positively after the conclusion of the meeting. The meeting presented an opportunity for both leaders to present grievances and warnings to the other (and show toughness to their domestic constituencies).  Other than presenting the opportunity to blow off steam, the results of the meeting appear modest:  the agreement to return ambassadors to their posts, to resume bilateral arms control discussions, to conduct discussions on “strategic stability” and to hold unspecified consultations on cyber. In typical fashion, Mr. Putin rejected all of Mr. Biden’s assertions about Russian actions and made counter accusations referencing hostile US actions.

Of the deliverables from the summit, cyber will no doubt turn out to be the most problematic area for follow up. Mr. Biden apparently delivered to Mr. Putin a list of 16 US critical infrastructure sectors that should be considered “off limits” for cyberattacks, e.g., “red lines” not to be crossed without the risk of significant retaliation. For his part, Mr. Putin asserted that it is Russia that is the victim of cyberattacks originating from the territory of the US and it’s NATO partners and also is the victim of  attempts to interfere with Russian elections.  The challenge in cyber discussions going forward will center around three areas:  differing interpretations of the relevance of deterrence theory in today’s cyber environment, attribution, and control.

Mr. Biden’s firm comments to Mr. Putin on recent cyberattacks against the US such as the ransomware attack on Colonial Pipelines (Mr. Biden is said to have asked Mr. Putin how he would react if Russia’s pipelines were hit?) and his provision of a list of “off limits” US infrastructure entities suggests a deep belief in this administration that Russia can be deterred from engaging in future conduct of cyber operations against US targets or “sanctioning” attacks originating from the territory of the Russian Federation by criminal groups.

Unfortunately, it is highly likely that either Mr. Putin nor those who control the levers of Russian cyber operations agree that deterrence theory applies.  Deterrence only works when both sides know the other is capable of – and willing to – cause significant harm to the other.

The Russian side likely believes (and may have amply demonstrated) that the US is disproportionately vulnerable to cyber risk at every level of its economic, societal, and political infrastructure whereas Russia is not.  There is a reason the use of cyber tools has become a central feature of Russian strategic doctrine. They work and seem a legitimate tool that falls short of conventional war. Hybrid warfare using cyber tools, the Russian side would argue, is no different than the economic warfare Russia is experiencing from sanctions imposed by the US its allies.

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EXPERT PERSPECTIVE — A meeting – albeit virtual – between President Joe Biden and Chinese President Xi Jinping finally happened.  It was a cordial and reportedly candid exchange that hopefully cooled some of the tension between the U.S. and China.

President Biden captured the essence of the meeting with his concern that this tension “does not veer into conflict, whether intended or unintended.”  President Xi said, “China and the U.S. need to increase communications and cooperation” and “respect each other and coexist in peace.”

It’s hard to believe that in 1979, when formal U.S. – China diplomatic relations were established, Chinese President Deng Xiaoping looked to the U.S. as the country that would provide the investment, technology, and unlimited access to our best universities.  And the U.S. didn’t disappoint.  Investment and sophisticated technology flowed to China, with hundreds of thousands of Chinese students enrolling in our universities.  Strategic bilateral cooperation initially contributed to the defeat of the Soviet Union in Afghanistan, with joint efforts to address international terrorism and nuclear proliferation.

So, during the span of forty-two years, relations have gone from close economic and strategic cooperation to a concern about conflict, intended or unintended.  Understandably, scholars will spend considerable time analyzing what went wrong. 

What is important now is that U.S. – China relations move in a more positive direction.  That tension over China’s aggression against Taiwan, the militarization of islands and reefs in the South China Sea, internment camps for Uyghurs in Xinjiang, the national security law in Hong Kong that suppresses democratic protests and the theft of intellectual property all must be candidly discussed by our diplomats and leaders to avoid misunderstanding and accidental conflict.

President Biden said Washington continues to have a “one China” policy and “opposes unilateral efforts to change the status quo.”  President Xi reportedly said, “Beijing will take decisive measures if the pro-Taiwan independence movement crosses a red line.”

The three communiques and the Taiwan Relations Act of 1979 specifically states that, inter alia, “the United States decision to establish diplomatic relations with the People’s Republic of China rests upon the expectation that the future of Taiwan will be determined by peaceful means; to consider any effort to determine the future of Taiwan by other than peaceful means, including by boycotts or embargoes, is a threat to the peace and security of the Western Pacific area and of grave concern to the United States.”

The challenge for the U.S. and China is to address Taiwan and a myriad of other irritants in the bilateral relationship to ensure that no one issue, or series of issues leads to conflict.  Toning down the rhetoric and pursuing a policy of substantive and sustained communications, especially by our diplomats, would be a necessary first step.


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The annual Economic and Strategic Dialogue with China, led by the heads of State Department and Treasury and their counterparts in Beijing was established to oversee progress in addressing these and other challenging issues.  A forum of this type, with announcements to ensure that the public is kept apprised of the issues and the work being done to resolve these issues, is of value, only if this dialogue is substantive and not just ceremonial.

This virtual presidential summit can be transformative if, in addition to addressing these and other irritants, it also addresses the opportunity to cooperate on a multitude of geopolitical issues that affect the security of the U.S. and China – and the world.

I’ll start with the nuclear issue and the fact that there’s minimal dialogue with China on its nuclear program.  And given recent reporting on the three sites in China with the construction of hundreds of missile silos and the recent DIA report that China, by 2030, will have a nuclear arsenal of 1000 nuclear warheads is of concern.  Ideally, China should be part of New Start arms control negotiations with the U.S. and Russia.  But they previously refused to join in this or any other arms control dialogue.  At a minimum, China should be responsive to a dialogue with the U.S. on nuclear-related issues, to include their recent test of two hypersonic missiles.

A separate but equally important dialogue with China is on cyber, to ensure that the cyber domain is not weaponized and used against our private sector for economic advantage.  Also, to ensure that outer space is used exclusively for peaceful purposes.

There are a multitude of global issues requiring bilateral cooperation.  We recently saw some U.S. – China cooperation on climate change at the Glasgow COPS 26 UN Climate Change Conference.  Obviously, more must be done, but this is a positive first step.

Other issues, like North Korea can and should be addressed now.  China has unique leverage with a North Korea that relies on China for its economic survival.  China can use that leverage to get North Korea to return to negotiations and to convince the North that complete and verifiable denuclearization, in return for significant deliverables, is in North Korea’s interest.

With over five million global casualties and over 760,000 deaths in the U.S. due to COVID-19, it should be obvious that greater bilateral cooperation on this and future pandemics is necessary.


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Bilateral cooperation on nuclear proliferation, countering international terrorism, the trafficking of narcotics and confronting international organized crime are just some of the global issues that affect the security of the U.S. and China and the global community.  Failure to cooperate on these and other international issues is not only a security imperative, but a moral responsibility of all great powers.

Finally, with the Taliban back in control in Afghanistan, the U.S. and China have a shared goal: ensuring that the Taliban does not permit Al Qaeda and other terrorist organizations to once again use Afghanistan as a base for its international terrorist operations. China has engaged this Taliban government and should use its significant financial leverage to ensure that all terrorist groups are permanently removed from Afghanistan.

Xi Jinping was just anointed by the Chinese Communist Party as one of its revered leaders, with Mao Zedong and Deng Xiaoping.  The Party congress next year will likely give Xi a third five-year term as the Party’s Secretary General.  There are a multitude of domestic issues requiring Xi’s and the Party’s attention, to include a campaign of “common prosperity” – addressing the disparity of wealth in a China governed by a capitalist system with Chinese characteristics.

Hopefully, President Xi Jinping will work with President Joe Biden to ensure that the two great powers, consumed with domestic issues, will also address the myriad of international issues requiring immediate and long-term attention and avoid a cold war that could veer into conflict.

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General Joseph L. Votel (Ret.) joined BENS as CEO & President in January 2020 following a 39-year military career where he commanded special operations and conventional forces at every level; last serving as the Commander of U.S. Central Command (CENTCOM) where he was responsible for U.S. and coalition military operations in the Middle East, Levant, and Central and South Asia. General Votel’s career included combat in Panama, Afghanistan, and Iraq and he led the 79-member coalition that successfully liberated Iraq and Syria from the Islamic State Caliphate. General Votel preceded his assignment at CENTCOM with service as the Commander of U.S. Special Operations Command and the Joint Special Operations Command.

The Cipher Brief:  Did you ever envision that the U.S. would pull out so quickly or completely leaving the Afghan military on its own without U.S. air support?  

General Votel: I did not anticipate this during my time – but once the President sets a hard departure date – then a fast withdrawal is inevitable.  No Commander wants to accept unnecessary risk with troops on the ground when you are up against a clearly articulated departure date.

The Cipher Brief: Intelligence assessments wildly missed the mark on how fast Kabul would fall, what factors contributed most directly to this? 

General Votel: Certainly, the departure of our own capabilities is a big part of this; the lack of direct contact with Afghan leaders is another important factor; and, of course, once it was clear that we were departing (and took our Commander out) — we lost priority and access with our normal and reliable Afghan intelligence sources.

The Cipher Brief: U.S. personnel are facing a deteriorating security situation at the Kabul airport while U.S. forces are still deploying for the contingency operation, another sign that the administration underestimated how fast the Taliban would reach Kabul. The U.S. could have chosen to slow the Taliban advance using airpower, why didn’t it happen, do you think? 


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General Votel: I think it is very clear that this was no longer a priority for our Government.  The mission right now, at least articulated over the weekend, is about supporting evacuation of the diplomats and helping with the departure of those Afghans who assisted the US and meet the criteria for evacuation.  While I don’t know this for certain — I believe what we were trying to do with over the horizon air support in a rapidly developing situation, was not optimal or overly effective.  It doesn’t seem to have done much – if anything.

The Cipher Brief: The U.S. has allowed U.S. supplied military hardware, weapons and technology to fall into the hands of the Taliban, a group responsible for the deaths of U.S. personnel and thousands of innocent Afghans.  The U.S. government holds private citizens and corporations accountable for far lesser violations of export violations involving dual-use technology or military equipment, etc.  How should Americans think about this situation now, where the Taliban will use equipment, paid for the by the U.S. taxpayer, to potentially perpetrate acts of violence against U.S. interests, and erode democratic values that the U.S. tried to introduce to Afghanistan?  

General Votel: Not sure on this.  Unfortunately, it is not the first time we have seen this — remember ISIS in 2014, in Mosul?  I suspect these will be more trophy pieces than they will be hard military capability – with the exception of small arms, mortars, and artillery.  Most of this will be difficult for the Taliban to sustain – and they probably prefer their own gear, anyway.

The Cipher Brief:  There is a lot of anger among the national security community right now.  What would you say to individuals who have suffered because of the U.S. role in Afghanistan, who may be feeling anger and rage?  

General Votel: I can’t really comment on anger in the national security community — I am sure that exists, but the sentiment that seems more strong to me, is disappointment.  No one wants what we are seeing now.  I think most security professionals can accept a decision to depart by the Commander in Chief — that is well within his authority, and everyone understands this; what is harder to accept is the manner in which this happened, and how it has played out.  It was hard for me to watch Taliban sitting at a conference table that I once sat at with the Afghan President.  In a number of public engagements, I have participated in lately – people have asked me if this whole effort was a waste.  My response has been consistent.  American military personnel, members of the IC and the diplomatic corps conducted themselves honorably throughout this war.  They responded when the Nation called and did their best for our Country, each other, and the Afghan people.  There will be plenty of time to place the blame – but the vast, vast majority of Americans who participated in some aspect of the Afghan War did so nobly and to the best of their ability.  We should not lose sight of this.  That this did not turn out the way we all hoped — is not their fault … and I would not want anyone (especially families of our wounded and killed) to think these efforts were in vain.  That is not how I thought about them at the time, and it is not how I think about them now.  They answered when the Nation called.

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Scientists have used artificial intelligence to “predict” formulas for new designer drugs, with the stated goal of helping to improve their regulation. The AI generated formulas for nearly nine million potential new drugs.

Researchers with the University of British Columbia (UBC) used a deep neural net for the job, teaching it to make up chemical structures of potential new drugs. According to their study, released this week, the computer intelligence fared better at the task than the scientists had expected.

The research team used a database of known designer drugs – synthetic psychoactive substances – to train the AI on their structures. The market for designer drugs is ever-changing, since their manufacturers are constantly tweaking their formulas to circumvent restrictions and produce new “legal” substances, while cracking their structure takes months for law enforcement agencies, the researchers said.

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FILE PHOTO: A man living on the streets displays what he says is the synthetic drug fentanyl, in the Tenderloin section of San Francisco, California, February 27, 2020 © Reuters / Shannon Stapleton
Drug overdose deaths in US hit all-time record

“The vast majority of these designer drugs have never been tested in humans and are completely unregulated. They are a major public-health concern to emergency departments across the world,” one of the researchers, UBC medical student Dr. Michael Skinnider has said.

After its training, the AI was able to generate some 8.9 million potential designer drugs. Afterwards, researchers ran a data sheet of some 196 new drugs, which had emerged in real life after the model was trained, and found that more than 90% of these have been already predicted by the computer.

“The fact that we can predict what designer drugs are likely to emerge on the market before they actually appear is a bit like the 2002 sci-fi movie, Minority Report, where foreknowledge about criminal activities about to take place helped significantly reduce crime in a future world,” senior author Dr. David Wishart, a professor of computing science at the University of Alberta, has said.

Identifying completely unknown substances remains an issue for the AI, the research team has noted, but they hope it might potentially help with that task, since the computer was also able to predict which formulas of designer drugs were more likely to be created and hit the market. The model “ranked the correct chemical structure of an unidentified designer drug among the top 10 candidates 72 percent of the time,” while throwing in spectrometry analysis, which is an easily obtained measurement, bumped the accuracy to some 86%.

“It was shocking to us that the model performed this well, because elucidating entire chemical structures from just an accurate mass measurement is generally thought to be an unsolvable problem,” Skinnider stated.

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AstraZeneca has announced that its preventative antibody cocktail offers 83% protection against symptomatic Covid-19 for at least six months, making it more effective than its own vaccine.

In a statement on Thursday, AstraZeneca cemented its lead in the race to develop and market a preventative Covid-19 drug, which is delivered as a shot in the arm. 

The drug, named AZD7442, reduces the risk of symptomatic Covid-19 by 83% over the course of six months, according to data from a trial in which participants were given one 300mg dose. There were no deaths or severe infections recorded within the trial group, it said. 

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A separate trial showed the drug reduced the risk of severe Covid-19 or death by 88% when administered within three days of the onset of symptoms. 

“These new data add to the growing body of evidence supporting AZD7442’s potential … We are progressing regulatory filings around the world and look forward to providing an important new option against SARS-CoV-2 [Covid-19] as quickly as possible,” AstraZeneca Executive Vice President Mene Pangalos said in the statement. 

The Anglo-Swedish firm has agreed to supply the US government with 700,000 doses of AZD7442 if the Food and Drug Administration grants it emergency use, which AstraZeneca requested on October 5. The firm has similar agreements with other nations. 

The drug is created using a combination of two antibodies originating from immune B-cells donated by a recovering Covid-19 patient. 

The treatment could be used in people who are known not to respond well to vaccines, such as cancer patients. Around 2% of people are considered to be at risk of not creating enough antibodies following the administration of a Covid-19 vaccine. 

Based on the numbers, the drug appears to be more effective than the firm’s first-generation Covid-19 vaccine. Britain’s Zoe Covid study showed the effectiveness of the vaccine dropped to around 67% after four to five months. 

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