Scientists in Sweden claim that a single protein in the blood could predict the onset of Type 2 diabetes nearly 20 years in advance. The breakthrough potentially affects hundreds of millions of people worldwide.
Diabetes is the world’s ninth-leading cause of death, and affects nearly half a billion people worldwide, according to the World Health Organisation (WHO). The vast majority of diabetes patients suffer from Type 2 diabetes, a condition that can lead to blindness, kidney failure, heart attacks, strokes, and lower limb amputation. Cases of diabetes quadrupled worldwide between 1980 and 2014, with unhealthy diets and lack of exercise blamed for the rise.
However, researchers at Lund University in Malmo, Sweden claim that elevated levels of a certain protein – follistatin – in the blood can predict the onset of Type 2 diabetes regardless of a person’s age, weight, diet or activity level. In a study published last week, the scientists wrote that high levels of follistatin can predict the condition up to 19 years before symptoms appear.
To discover the link between follistatin and diabetes, the researchers tracked 5,300 people from Sweden, Italy, and the UK for between four and 19 years. Follistatin helps break down body fat, while simultaneously leading to an increase in fat in the liver. This buildup can cause fatty liver disease and Type 2 diabetes.
“This study shows that follistatin has the potential to become an important biomarker to predict future Type 2 diabetes, and it also brings us one step closer to the understanding of the mechanisms behind the disease,” Dr. Yang De Marinis, associate professor at Lund University and lead author of the study, told a university newsletter. De Marinis added that the next step for her team would be to help develop an AI-based diagnostic tool that could analyze a patient’s blood sample and use their follistatin levels – and other biomarkers – to calculate their “risk score” for Type 2 diabetes.
As follistatin levels rise in response to food intake and activity levels, the same advice for prevention of diabetes still applies. “Balanced meals, eat[ing] healthy and regular exercise are important to decrease the risk of developing Type 2 diabetes,” De Marinis told StudyFinds.
Think your friends would be interested? Share this story!
People around the world will need to get a jab against Covid-19 once a year, at least when it comes to the Pfizer vaccine, BioNTech’s CEO Ugur Sahin said in an interview on Sunday, as he praised the quality of its booster shot.
In an interview with Germany’s Bild newspaper on Sunday, Sahin said he considers the vaccine, co-developed by his company, to be “very effective.”
When asked whether people should be worried about the “breakthrough infections” – in which those vaccinated with the Pfizer-BioNTech vaccine still developed Covid-19 symptoms – he dismissed such concerns, saying that the jab offers a “90 percent protection” against cases that require intensive care in those aged over 60.
A “very high” level of protection against severe illness lasts for up to nine months, the BioNTech CEO maintained. He said this level starts decreasing “from the fourth month,” however. To maintain the protection, Sahin strongly pushed for booster shots, arguing that they would not just restore levels of antibodies but would potentially help “to break … chains of infection.”
He also encouraged doctors to be “as pragmatic as possible” when it comes to greenlighting vaccination and “not to send people home unvaccinated even though they could be vaccinated without any problems.”
In the future, people might need to get booster shots once a year, the BioNTech CEO believes. He said that he expects protection from a booster shot to “last longer” than the initial immunity one acquires after getting two doses of the vaccine.
“Subsequent … vaccinations may only be needed every year – just like [with] influenza,” he said. Currently, the German Federal Center for Health Education – an agency subordinated to the Health Ministry – recommends a booster shot six months after one gets the second dose of a vaccine. It also says that “booster vaccination makes sense after a minimum interval of about four months.”
Sahin’s interview comes days after it was revealed that Pfizer, BioNTech and Moderna are making a combined profit of $65,000 every minute – all thanks to their Covid-19 jabs. That is according to estimates made by the People’s Vaccine Alliance (PVA) – a coalition demanding wider access to vaccines.
The PVA estimated that the three companies are to earn a total of $34 billion in combined pre-tax profits this year alone, which roughly translates into more than $1,000 a second and $93.5 million a day.
PVA has slammed the three companies over their refusal to allow vaccine technology transfer despite receiving a combined $8 billion in public funding. Such a move could increase global supply and save millions of lives as well as drive down prices, the coalition said.
“Pfizer, BioNTech and Moderna have used their monopolies to prioritize the most profitable contracts with the richest governments, leaving low-income countries out in the cold,” said Maaza Seyoum of the African Alliance and People’s Vaccine Alliance Africa.
Think your friends would be interested? Share this story!
When you think the internet can’t get any more niche, it finds a way to get even more specific. We’re, of course, talking about an Instagram account @BagDogs that is solely dedicated to sharing people’s photos of dogs chilling in bags as they are being transported from point A to point B. Scroll down to see some of their best photos!
Hundreds of major websites returned ‘404: not found’ errors after an apparent problem with Google Cloud. Alphabet said the problem was “partially resolved” after about ten minutes, but it will take time for everything to update.
The site Downdetector began showing a spike in reports of outages starting at 12:40pm Eastern time on Tuesday, affecting Google, Facebook, Instagram, Snapchat, Discord, Spotify, and TikTok, as well as e-commerce sites Target, Etsy, Shopify, and Home Depot, among others.
Amazon, Amazon Web Services (AWS), and Cloudflare were also affected.
Google’s Status Dashboard reported an unspecified “issue” with the Cloud service starting at 10:10 Pacific, which was causing users to encounter errors when accessing websites.
“We believe the issue with Cloud Networking is partially resolved,” the company said by 10:17 PST, but it added that “Customers will be unable to apply changes to their load balancers until the issue is fully resolved,” and they did not have an estimate as to when that might be.
Think your friends would be interested? Share this story!
An official inquiry has found that Germany’s justice system was staffed with former Nazis for decades after the Second World War, At one point, three out of four top officials at the prosecutor’s office were former party members.
Released on Thursday, the 600-page report was compiled by historian Friedrich Kiessling and legal scholar Christoph Safferling, and covers the Cold War period running from the early 1950s until 1974. The work was commissioned by the federal prosecutor’s office.
The researchers found that, at one point during the 1950s, roughly three in four top officials in the federal prosecutor’s office had been members of the Nazi Party. It took until 1972 before former Nazis were no longer in the majority in that office, and until 1992 before the judicial system had been fully purged of ex-members of the fascist party.
“There was no break, let alone a conscious break, with the Nazi past,” the researchers said of the situation.
Presenting the inquiry’s findings, state secretary at the justice ministry Margaretha Sudhof said the country has “long remained blind” to the presence of ex-Nazis in senior positions after the end of the Second World War.
“On the face of it they were highly competent lawyers… but that came against the backdrop of the death sentences and race laws in which they were involved,” Sudhof commented.
In a statement about the study’s publication, Justice Minister Christine Lambrecht said she welcomed “the fact that the Federal Prosecutor’s Office is also grappling with its troubled past and is shedding more light on its own Nazi entanglements in the post-war period.”
The federal prosecutor’s office is Germany’s highest prosecutorial authority, responsible for pursuing those who violate international law and commit alleged crimes relating to state security.
The latest study follows an earlier report published in 2016, which stated that in 1957 – more than a decade after the war had ended – 77% of senior officials in the justice ministry were former Nazis. At the time of that publication, then-Justice Minister Heiko Maas stated that the “Nazi-era lawyers went on to cover up old injustice rather than to uncover it, and thereby created new injustice.”
When the PRC decides to move on Taiwan, it is unlikely to move in a manner that makes a US decision on intervention clear cut. Should China decide, initially at least, against a full-scale invasion of that island nation, it could instead opt to try to “win without fighting.” Beijing might do so by using its large, state-controlled fishing fleet to cut smaller Taipei-controlled islands off from Taiwan itself much as the PRC is now massing fishing boats to expand Chinese-controlled seas to press claims on the Japanese Senkakus and Whitsun Reef in Philippine waters. Chinese state-owned fisheries companies – part of the so-called ‘Maritime Militia’ – serve as fronts for PLA intelligence. Using their fleets to operate in a manner somewhere between peace and conflict in the gray zone of contested control around Taiwan would allow Beijing to test whether the US and its allies are willing to help defend the island’s independence without being seen to initiate open conflict.
“The Cipher Brief has become the most popular outlet for former intelligence officers; no media outlet is even a close second to The Cipher Brief in terms of the number of articles published by formers.” – Sept. 2018, Studies in Intelligence, Vol. 62 No.
Access all of The Cipher Brief’s national-security focused expert insight by becoming a Cipher Brief Level I Member .
The Funniest Clothing Labels Ever – When was the last time you read the label on your favorite shirt or most comfortable pair of jeans? Maybe it’s time to take a look, your clothing tags may hide a funny message.
The Perfect Gift For Someone You Hate – Hungry AND tired? You can rest on this soft body pillow shaped like smoked pig’s feet! What really amazes us are the details, it looks so real… and so disgusting.
Every Cat at 3AM – If you currently have or have ever had a cat, you’ll be able to relate to Gus Johnson’s video, in which he demonstrates one of the many ways in which our furry friends can be a-holes.
The Funniest Dog Videos Of All Time – We understand the value of a good funny dog video, so here’s a list of our six best viral pup videos of all time. You’re welcome.
Mildly Infuriating Things In Life – Sometimes the internet shows you a photo that’s ever so slightly wrong that it sticks in your brain forever…
Random Funny Pictures – What do you do when you are bored at work? You just mindlessly scroll through random funny pictures, of course!
Mr. Bean Playing Every Role In Hollywood – When one thinks of a rugged, versatile actor capable of elevating any role given to them, Mr. Bean naturally springs to mind. And yet he was never cast as Frodo Baggins or Indiana Jones, which in our eyes is one of the saddest tragedies of modern filmmaking.
Just three days after restrictions were announced for unvaccinated Austrians, a provincial governor is pressing for a nationwide lockdown of all residents as Covid-19 infections continue to hit record highs.
“If no national lockdown is ordered tomorrow, there will definitely have to be a lockdown of several weeks in Upper Austria, together with our neighboring province Salzburg as of next week,” Upper Austria Governor Thomas Stelzer told lawmakers on Thursday.
That will mean at least two of Austria’s nine provinces will be in full lockdown mode just days after the nation created a two-tier society by locking down approximately two million unvaccinated Austrians.
“We must raise the vaccination rate. It is shamefully low,” Chancellor Alexander Schallenberg said on Sunday, announcing that unvaccinated residents would only be allowed to leave their homes for “essential” purposes, such as to buy groceries or go to a doctor’s office.
Police are now doing random checks for proof of vaccination on Austrian streets. Those unvaccinated residents who are found to be in violation of the lockdown order face steep fines of up to €500. Those who refuse to go through a vaccination status check will have to pay about three times as much.
Stelzer and other Austrian governors are scheduled to meet with Schallenberg and Health Minister Wolfgang Mueckstein on Friday, when a full lockdown will likely be considered.
New Covid-19 cases in the country passed the 15,000 mark for the first time on Thursday, far surpassing 2020’s daily high of 9,586, set when no vaccines were available. Upper Austria and Salzburg have been hit the hardest, putting hospitals at risk of bed shortages. With some 66% of its population fully vaccinated, Austria lags behind other Western European countries in terms of the Covid-19 vaccination rate.
While Austria is the first to impose a lockdown on the unvaccinated, other EU countries – including Slovakia, the Czech Republic and Greece – have imposed increasingly tight restrictions on people who haven’t accepted a Covid vaccine.
Think your friends would be interested? Share this story!
Extinction Rebellion has targeted Colombian diplomatic missions across several EU countries, including France and Italy, demanding that the nation address deforestation, coal mining, and indigenous peoples’ rights.
The hard-line climate activist group staged simultaneous protests outside several of Colombia’s diplomatic missions on Tuesday, calling on Bogota to protect biodiversity and stop deforestation. It also urged the country’s government to take action against the El Descanso open-pit coal mine, which is said to be threatening the Yukpa indigenous people.
The French branch of the activist group targeted the Colombian Embassy in Paris, vandalizing its entrance. Footage from the scene shows activists dousing the mission’s entrance in black paint, while plastering placards over its walls.
Action de @xrFrance a l’ambassade de Colombie à #Paris pour dénoncer l’inaction du gouvernement Colombien pour la protection de la biodiversité et des peuples indigènes. pic.twitter.com/1hpf3vVxK4
Another protest held outside Colombia’s consulate in Milan, Italy, saw that mission vandalized too. The building’s entrance was covered in fake blood, with a pile of a black substance, which looked like charcoal or coal, left by its doors.
#ATENCIÓN| Así se vive la Minga Internacional en el Consulado de Colombia en la ciudad de Milán, Italia, donde defensores del medio ambiente alzan su voz por el respeto a la vida y del territorio ancestral del Pueblo Yukpa.
— Organización Nacional Indígena de Colombia – ONIC (@ONIC_Colombia) November 16, 2021
Demonstrations also took place outside Colombia’s missions in Germany’s capital, Berlin, as well as in Madrid, Spain. Those protests appeared to be more civil, with activists rallying outside of the missions without vandalizing them.
Hard-line cleric Ebrahim Raisi won Iran’s presidential election on Saturday in a move that is expected to bolster the conservative legacy of the country’s supreme leader, Ayatollah Ali Khamenei.
The decision is not expected to derail ongoing negotiations aimed at restoring the Joint Comprehensive Plan of Action (JCPOA) nuclear deal, even though Mr. Raisi himself is under US sanctions over accusations of human rights abuses. Many voters stayed away from the polls as the outcome had been predicted for months with many progressive candidates barred from running.
“The Islamic Republic has entered a post-revolutionary dynamic in which a fading revolutionary generation seeks to ensure that the rising political leadership sustains their revolutionary ideals,” says Norman T. Roule, former National Intelligence Manager for Iran at ODNI and Cipher Brief Expert. “The regime’s decision to bar so many candidates and the low turnout make this election a historic embarrassment for the regime and its supporters.”
The Cipher Brief talked with Roule about what the election means and what it doesn’t mean when it comes to relations with the west, the progressive movement within Iran and the election’s impact on the oil markets.
“The Cipher Brief has become the most popular outlet for former intelligence officers; no media outlet is even a close second to The Cipher Brief in terms of the number of articles published by formers.” – Sept. 2018, Studies in Intelligence, Vol. 62 No.
Access all of The Cipher Brief’s national-security focused expert insight by becoming a Cipher Brief Level I Member .
