Scientists have used artificial intelligence to “predict” formulas for new designer drugs, with the stated goal of helping to improve their regulation. The AI generated formulas for nearly nine million potential new drugs.
Researchers with the University of British Columbia (UBC) used a deep neural net for the job, teaching it to make up chemical structures of potential new drugs. According to their study, released this week, the computer intelligence fared better at the task than the scientists had expected.
The research team used a database of known designer drugs – synthetic psychoactive substances – to train the AI on their structures. The market for designer drugs is ever-changing, since their manufacturers are constantly tweaking their formulas to circumvent restrictions and produce new “legal” substances, while cracking their structure takes months for law enforcement agencies, the researchers said.
“The vast majority of these designer drugs have never been tested in humans and are completely unregulated. They are a major public-health concern to emergency departments across the world,” one of the researchers, UBC medical student Dr. Michael Skinnider has said.
After its training, the AI was able to generate some 8.9 million potential designer drugs. Afterwards, researchers ran a data sheet of some 196 new drugs, which had emerged in real life after the model was trained, and found that more than 90% of these have been already predicted by the computer.
“The fact that we can predict what designer drugs are likely to emerge on the market before they actually appear is a bit like the 2002 sci-fi movie, Minority Report, where foreknowledge about criminal activities about to take place helped significantly reduce crime in a future world,” senior author Dr. David Wishart, a professor of computing science at the University of Alberta, has said.
Identifying completely unknown substances remains an issue for the AI, the research team has noted, but they hope it might potentially help with that task, since the computer was also able to predict which formulas of designer drugs were more likely to be created and hit the market. The model “ranked the correct chemical structure of an unidentified designer drug among the top 10 candidates 72 percent of the time,” while throwing in spectrometry analysis, which is an easily obtained measurement, bumped the accuracy to some 86%.
“It was shocking to us that the model performed this well, because elucidating entire chemical structures from just an accurate mass measurement is generally thought to be an unsolvable problem,” Skinnider stated.
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Reuters has apologized for its poor choice of photo to illustrate a story about a monkey brain study that was deemed offensive and racist in China.
On Thursday, Reuters published a story titled “Monkey-brain study with link to China’s military roils top European university.” The report was about a Chinese professor studying how a monkey’s brain functions at extreme altitude.
The study was done with the help of Beijing’s People’s Liberation Army (PLA) with the aim of developing new drugs to prevent brain damage, Reuters said.
The news agency promoted the story on Twitter with a photo of smiling Chinese soldiers in an oxygen chamber.
The tweet prompted outrage in China, with people calling it racist on social media. Reuters responded on Friday night by deleting the original tweet because the photo of Chinese soldiers was unrelated to the story and “could have been read as offensive.”
PHOTO CORRECTION: We have deleted an earlier tweet that included a picture of Chinese soldiers in an oxygen chamber not described in the original tweet that could have been read as offensive https://t.co/Ahtv9fj8EQ 2/2
“As soon as we became aware of our mistake, the tweet was deleted and corrected, and we apologize for the offense it caused,” Reuters said in a statement to the Global Times, China’s state-run newspaper.
It was not the first time the leading Western news agency had run into trouble in China. In July, the Chinese Embassy in Sri Lanka criticized Reuters for using a photo of Chinese weightlifter and Tokyo 2020 Olympics gold medalist Hou Zhihui that the country’s state media described as “ugly” and “disrespectful to the athlete.”
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France shouldn’t remain silent on Julian Assange, leftist leader Jean-Luc Melenchon has said, after the imprisoned WikiLeaks co-founder’s father suggested that Paris could offer asylum to his son.
The life of Assange – who is being held in solitary confinement at London’s Belmarsh maximum security prison while a British court considers an extradition request by the US – is under threat, Melenchon wrote on Twitter on Tuesday.
“For years, we’ve been calling for France to accept him,” the head of the leftist La France Insoumise (France Unbowed) party said, insisting that “France shouldn’t remain silent.”
The statement by Melenchon, who won 19.6% of the ballot in the first round of the French presidential election in 2017, follows a visit by Assange’s father, John Shipton, to the Whistleblower Meeting in Paris on Monday.
During the event, Shipton told Sputnik news agency that it would be “an honorable thing” for the French government to grant his son asylum.
“I feel that France hasn’t attacked Julian over the last 12 years and consequently France is free to act in return for the information that WikiLeaks and Julian brought to France,” he said, referring to the website’s revelations of the US intelligence agencies spying on French presidents and hacking into local banks.
🔴 John #Shipton : «La France n’a pas attaqué #Julian pendant les dernières années difficiles, donc la France est libre d’agir en échange des informations que #WikiLeaks et Julian ont apportées à la France. Ce serait honorable pour la #France d’offrir [l’asile] à Julian #Assange» pic.twitter.com/ceZ7qTARua
Several dozen French lawmakers have also recently called upon Paris to take Assange in, with the Australian-born publisher’s legal team saying last year that their client was hoping to find asylum on French soil.
Assange could face up to 175 years behind bars if he’s extradited to the US, where he’s wanted on espionage charges over the release by WikiLeaks of classified documents on Iraq, Afghanistan, Guantanamo Bay, and others.
He was placed in Belmarsh in April 2019 over breach of bail, after being holed up in the Ecuadorian Embassy in London for seven years.
The publisher had been fleeing an arrest warrant issued over sexual assault allegations which he has always denied, and which failed to result in any actual charges due to lack of evidence.
Assange’s supporters insist that he has actually been persecuted over his legitimate journalistic activities and revealing the truth to the public.
The UK High Court is expected to rule on the appeal by the US against a lower court decision to bar the WikiLeaks co-founder’s extradition to America due to the 50-year-old’s poor health condition and risk of suicide.
Assange’s team will then be able to challenge the ruling in the Supreme Court if it’s not favorable.
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Denmark’s air force showed off its brand-new electric-powered planes on Thursday, saying its test flights have so far proven that the cheaper-to-run, more eco-friendly technology has potential.
It had obtained the two Velis Electro jets from Slovenian manufacturer Pipistrel, becoming the first military in the world to operate this type of hardware.
“The aircraft are 100% emission-free, very quiet, and otherwise cheap to operate,” Lieutenant Colonel Casper Børge Nielsen of the Defense Ministry’s material and procurement agency said. Initial tests indicate “there may be perspectives in using electric aircraft when the technology becomes mature,” he added.
Denmark has leased the planes for two years, rather than buying it, to avoid the “risk of ending up with equipment that we can’t really use,” Børge Nielsen said. During the lease period, the Danish Air Force hopes to gain an insight into the benefits and disadvantages of the jets’ technology to decide how it can be applied in the future.
The pilots described flying the one-man light electric planes, which are powered by two lithium batteries, as “exciting,” saying they were “built well and fly well.”
Last year, the United States military said it had been keeping an eye on the development of electric-powered planes, describing their ability to approach targets silently as “tremendous.” However, their battery capacity isn’t currently sufficient to meet the US Air Force’s needs.
Work on electric aircraft has been underway since the 1970s, but the battery issue has been a stumbling block in the way of wider adoption of the technology. Global military interest could change all that, stimulating research and investment.
The switch to electric power is likely to be a win-win across the board, as it will drastically reduce CO2 emissions and also make flying much cheaper for commercial carriers and their passengers.
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The Philippine government has accused the Chinese Coast Guard of unleashing water cannon on two supply ships in a disputed stretch of the South China Sea, claiming its boats were blocked and forced to turn around.
Manila’s Department of Foreign Affairs detailed the encounter in a statement on Wednesday, alleging that a pair of supply boats en route to the Ayungin Shoal – also known as the Second Thomas Shoal – were stopped by three Chinese vessels and “water cannoned” before they could reach their destination.
“Fortunately, no one was hurt; but our boats had to abort their resupply mission,” Foreign Affairs Secretary Teodoro Locsin said, adding that the department had conveyed its “outrage, condemnation and protest of the incident” to Beijing’s envoy to the Philippines, Huang Xilian.
The acts of the Chinese Coast Guard vessels are illegal. China has no law enforcement rights in and around these areas. They must take heed and back off.
Though both China and the Philippines claim territorial rights to the Ayungin Shoal, The Hague’s Permanent Court of Arbitration ruled in the latter country’s favor in 2016. And despite Chinese objections, the Philippines has occupied the area for much longer, after its military purposely grounded a naval vessel on the shoal in 1999.
[3] I reminded China that a public vessel is covered by the Philippines-United States Mutual Defense Treaty.
Manila was also quick to note that the supply ships are “covered by the Philippines-United States Mutual Defense Treaty,” a pact inked with Washington in 1951 that calls for a US military response to any attack on the country, including “island territories under its jurisdiction in the Pacific Ocean, its armed forces, public vessels or aircraft.”
Beijing so far has not commented on the alleged run-in.
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