Scientists have used artificial intelligence to “predict” formulas for new designer drugs, with the stated goal of helping to improve their regulation. The AI generated formulas for nearly nine million potential new drugs.
Researchers with the University of British Columbia (UBC) used a deep neural net for the job, teaching it to make up chemical structures of potential new drugs. According to their study, released this week, the computer intelligence fared better at the task than the scientists had expected.
The research team used a database of known designer drugs – synthetic psychoactive substances – to train the AI on their structures. The market for designer drugs is ever-changing, since their manufacturers are constantly tweaking their formulas to circumvent restrictions and produce new “legal” substances, while cracking their structure takes months for law enforcement agencies, the researchers said.
“The vast majority of these designer drugs have never been tested in humans and are completely unregulated. They are a major public-health concern to emergency departments across the world,” one of the researchers, UBC medical student Dr. Michael Skinnider has said.
After its training, the AI was able to generate some 8.9 million potential designer drugs. Afterwards, researchers ran a data sheet of some 196 new drugs, which had emerged in real life after the model was trained, and found that more than 90% of these have been already predicted by the computer.
“The fact that we can predict what designer drugs are likely to emerge on the market before they actually appear is a bit like the 2002 sci-fi movie, Minority Report, where foreknowledge about criminal activities about to take place helped significantly reduce crime in a future world,” senior author Dr. David Wishart, a professor of computing science at the University of Alberta, has said.
Identifying completely unknown substances remains an issue for the AI, the research team has noted, but they hope it might potentially help with that task, since the computer was also able to predict which formulas of designer drugs were more likely to be created and hit the market. The model “ranked the correct chemical structure of an unidentified designer drug among the top 10 candidates 72 percent of the time,” while throwing in spectrometry analysis, which is an easily obtained measurement, bumped the accuracy to some 86%.
“It was shocking to us that the model performed this well, because elucidating entire chemical structures from just an accurate mass measurement is generally thought to be an unsolvable problem,” Skinnider stated.
Think your friends would be interested? Share this story!
Marx, Lenin, and Ho Chi Minh – the revolutionaries’ namesakes – have gathered for a wedding in India’s state of Kerala. Friedrich Engels was the one walking down the aisle.
And this has nothing to do with time travel. In India’s southwestern state of Kerala parents have often named their children after prominent figures in the hammer and sickle movement. The local communist party has been at the helm there for much of the past 60 years, and is still quite popular with voters.
In the town of Athirappilly on Sunday the groom, Friedrich Engels, a namesake of the 19th century German philosopher who helped conceive Marxism, tied the knot with the bride, Bismitha. In attendance were also Engels’s brother Lenin, named after the man behind the 1917 Russian Revolution, as well as the groom’s friends, Marx and Ho Chi Minh, who bear the names of Marxism’s founding father and the Vietnamese revolutionary leader respectively.
All four men are members of India’s Communist Party. Incidentally, Marx is currently working and residing in ultra-capitalist Dubai, but flew back to see his friend exchange wedding vows with his betrothed, as reported by local media.
Another wedding ceremony that took place in June in the state of Tamil Nadu, saw Socialism getting married in front of his brothers, Communism and Leninism, as well as nephew, Marxism.
Think your friends would be interested? Share this story!
Rotterdam Mayor Ahmed Aboutaleb has described an anti-lockdown protest in his city as an “orgy of violence.” The Dutch demonstration devolved into a violent riot that saw police open fire on protesters.
Aboutaleb described the events of Friday night as an “orgy of violence,” after protesters packed Rotterdam’s central Coolsingel shopping street to voice their opposition to an ongoing partial lockdown, a ban on New Year’s Eve fireworks displays, and the possibility of a two-tiered system of freedom in the Netherlands, one of liberty for the vaccinated and restrictions for those without the jab.
The protest soon got out of hand, and police said on Saturday that 57 people were arrested. Protesters were seen torching police vehicles and launching fireworks at police, who shot at them in response.
Aboutaleb said that the cops had been “forced” to use their weapons. “On a number of occasions the police felt it necessary to draw their weapons to defend themselves,” he told reporters. “They shot at protesters, people were injured.”
Police say at least seven people were injured. Two of these injuries were caused by police bullets, and the victims are still in hospital. One officer was hospitalized, while several others were treated at the scene for minor injuries.
The stars of the Harry Potter films will reunite for a 20-year anniversary special on HBO, minus author JK Rowling. Fans and commenters wondered if Rowling’s absence had anything to do with her views on transgender issues.
‘Harry Potter and the Sorcerer’s Stone’ premiered 20 years ago this week, catapulting actors Daniel Radcliffe, Rupert Grint, and Emma Watson to superstardom. Warner Bros announced on Tuesday that the three stars – as well as a whole range of supporting actors from the franchise – will travel back to Hogwarts for an “enchanting making-of story” airing on New Year’s Day, entitled ‘Harry Potter 20th Anniversary: Return to Hogwarts’.
Conspicuously absent from the production is author JK Rowling. A Warner Bros’ press release made no mention of Rowling, and a lengthy Instagram post by actress Emma Watson thanked fans and fellow cast members, but also made no mention of Rowling, whom other Harry Potter actors said they “owe everything” to.
Rowling’s PR team did not comment on the author’s absence, and the Hollywood Reporter claimed that the author will only appear in the show in archival footage.
Commentators online reckoned that Rowling had been canceled from the retrospective special due to her high-profile clashes with transgender activists. A self-described feminist, Rowling has spoken out against gender-neutral language, arguing that it “erases” the concept of sex and therefore the concept of womanhood. She has also stated that sex is a binary concept, and argued against gender-neutral bathrooms, claiming that by allowing men into women’s bathrooms, women are made less safe.
If I owed my entire career to 1 person, if I’d known her since I was 8, if I was worth $90m because of her, then not only would I defend her when maligned but I would refuse to take part in any reunion that excluded her. But that’s just me. #JKRowlinghttps://t.co/0ay5mhQ1FE
I can’t believe they’re actually shunning JK Rowling
“No you can’t participate in something celebrating the world you made because we are the new Amish but with more Puritan soul and no redeeming features”.
Rowling’s comments on gender issues generated intense backlash from LGBT organizations, and death and rape threats from the most zealous transgender ideologues online. Actors Daniel Radcliffe and Emma Watson also both spoke out against Rowling’s defense of biological sex last year, with Radcliffe declaring that “transgender women are women,” and apologizing to upset fans “for the pain [Rowling’s] comments have caused you.”
“Trans people are who they say they are and deserve to live their lives without being constantly questioned or told they aren’t who they say they are,” Watson chimed in.
Rowling has repeatedly stated that she is against anti-trans discrimination, but would not change her position on sex. “I refuse to bow down to a movement that I believe is doing demonstrable harm in seeking to erode ‘woman’ as a political and biological class and offering cover to predators like few before it,” she wrote last year.
Think your friends would be interested? Share this story!
Sporadic clashes broke out at massive Saturday demonstrations in major European cities, as thousands of people took to the streets of Vienna, Paris and Rome to express their discontent with Covid-19 restrictions.
The Austrian capital Vienna on Saturday saw the largest protest turnout since the start of the Covid-19 pandemic. A total of 38,000 people took to the city streets to join a dozen demonstrations protesting government measures.
Austria se colocó en pleno apartheid sanitario esta semana, mirando a Viena ahora mismo, no lo pensarías, recuerda que dependen únicamente de la conformidad del pueblo, la resistencia es clave. pic.twitter.com/tKRAIJ2GLt
— Creo en la justicia divina y terrenal 💞💞🇪🇸🇪🇸 (@Ninita0011) November 20, 2021
Tens of thousands have taken to the streets today in one of the largest protests in the history of Vienna, Austria, after the government implemented a new COVID lockdown and became the first in the world to announce compulsory vaccination.pic.twitter.com/FFriWCZioG
The protests came a day after the Austrian authorities ordered nationwide compulsory vaccination from February 1 and imposed a full lockdown, starting Monday. The massive procession that spanned over several kilometers marched along Vienna’s central ring road. The city center was paralyzed for several hours as traffic was restricted.
Austria’s right-wing Freedom Party, whose members joined the rallies, put the number of protesters at 100,000. Some demonstrations were also attended by members of various far-right groups. The protests were generally peaceful but footage published by Ruptly video news agency showed several scuffles between the police and the demonstrators breaking out.
Law enforcement spoke of a total of five arrests. One incident saw a protester attempting to grab an officer’s gun and take it from its holster. In another incident, the officers were pelted with bottles and fireworks and had to use pepper spray in response.
#w2011 Die Situation in Wien eskaliert. Die Polizei scheint, trotz der bekannten Grossmobilisierung und zahllosen Gewaltaufrufen, äusserst schlecht vorbereitet. An mehreren Orten wurde die Polizei umzingelt und musste sich zurückziehen. pic.twitter.com/4VzZTbww2S
Hundreds of kilometers away from Vienna, in the French capital Paris, events took a more dramatic turn. There, a demonstration against the government Covid-19 measures coincided with the third anniversary of the Yellow Vests movement. Hundreds of protesters took part in the protest, which quickly turned into clashes between the demonstrators and law enforcement.
The protesters were building barricades and setting them on fire as well as pelting police with bottles and various other projectiles. Law enforcement responded with profuse amounts of tear gas, sometimes filling entire streets with thick smoke to disperse the crowds.
PARIS – Un conteneur est renversé pour utiliser les bouteilles comme projectiles.
Rome saw a massive demonstration against Italy’s Covid-19 health pass, also known as the Green Pass. Some 4,000 people gathered in the center of the Italian capital, according to the police. The demonstrators were waving national flags and chanting “Freedom” and “No Green Pass,” referring to the vaccination certificate needed to enter various public venues such as clubs or bars.
The crowd staged a sit-in in the Circus Maximus – an ancient Roman chariot-racing stadium converted into a modern-day park. They remained there after sunset, lighting the area with thousands of phones and colored smoke bombs. The rally was peaceful, though, as the police did not report any incidents.
Unlike Rome, Italy’s northern city of Milano saw clashes between protesters and the police as law enforcement officers sought to break up an unauthorized rally at the city center. Large police forces were deployed to the city center and several squares were cordoned off.
Think your friends would be interested? Share this story!
A strike of more than 20,000 metal workers in Cadiz, Spain has halted the operations of key manufacturing plants, including Airbus and Alestis, with barricades erected, roads blocked, and vehicles burned.
Cadiz, the capital of the southernmost province of the country, has become one of the main sites of protests over working conditions. The Avenida de Astilleros is currently closed to traffic, with protesters burning vehicles.
Picket lines also blocked access to major shipbuilding and industrial sites of key local companies, such as Airbus, Navantia, Dragados, Alestis, and Acerinox, causing their work to be interrupted.
Protesters also cut off access to major industrial zones in Puerto Real and Campo de Gibraltar with barricades and bonfires. Rail traffic is also being obstructed, with pipes thrown onto the tracks.
The national police have been deployed to bring the situation under control and to protect the industrial sites. At one point on Tuesday, the strike turned into a full-scale confrontation, with protesters throwing rocks and screws at police, who reacted by firing rubber bullets. One person was arrested.
🎥🛑En #España 2º día y arden las calles de Cádiz en el segundo día de la #huelgadelmetal indefinida.
🔥🏴Todo nuestro apoyo a lxs trabajadorxs del sector del metal en #Cadiz.
The Federation of Metal Entrepreneurs (FEMCA), which represents major employers in the region, reiterated earlier its offer for dialogue with the workers, while stressing that the union’s requests were “unjustified” and “disproportionate.”
The workers say they will continue the strike until FEMCA provides them with an acceptable agreement.
Think your friends would be interested? Share this story!
Protesters thronged the streets of Australian cities on Saturday, demanding an end to what they called the “tyranny” and “oppression” of lockdowns, vaccine mandates, and the proposed expansion of the government’s pandemic powers.
In Melbourne, Sky News reporter Sophie Elsworth described “tens of thousands of people streaming through the streets.” The march came after a week of smaller protests aimed at Victoria Premier Dan Andrews’ controversial pandemic bill, which if approved by the state’s legislature would allow Andrews and Health Minister Martin Foley to declare an indefinite state of emergency and issue public health orders by decree – including “any order… that the minister believes is reasonably necessary to protect public health.”
Tens of thousands of people keep streaming through the streets. Many I’ve spoken to are concerned about the state govt, Premier, vaccine mandates, the pandemic bill & what future holds for their kids. #melbourneprotestpic.twitter.com/smexulQ4ts
Should the bill pass, it would allow Andrews to target certain classes of people with these orders, categorizing them by age, occupation, or vaccination status. Fines for noncompliance would range from up to AU$21,800 for people and AU$109,000 for businesses.
Alternative media sources claimed that more than 100,000 people showed up to protest. However, the demonstration remained free of the violent clashes seen at protests in Melbourne in recent months.
“Australia has been willing to send troops to all parts of the world to help people become free,” one military veteran told a crowd of listeners during the protest. “To now be fighting oppression here in our own country, it’s saddening.”
Melbourne Australia 🇦🇺
An Aussie veteran is calling former servicemen and cops who have sworn an oath to Australia to stand up against the tyranny 👊 pic.twitter.com/4RsoRMjoJE
Huge numbers of protesters also turned out in Sydney, and although more than 600 police officers were deployed to watch over the gathering, no arrests were made, 9News reported.
Holding signs decrying state “tyranny,” the demonstrators chanted “freedom” and called for the firing of state politicians who have implemented a two-tier system where the unvaccinated are denied many of the privileges extended to the fully jabbed.
Similarly massive gatherings took place in Adelaide, Brisbane, and Perth, with no notable incidents of violence or police action. Further afield, protests are taking place in more than 120 cities around the world this weekend, in a loosely coordinated event dubbed the ‘Worldwide Rally For Freedom’ by activists.
Thousands of people have descended across Rundle Park today as part of an Adelaide freedom rally. Some of those in the crowd say they have lost their job as a result of mandated vaccinations in their sector. @9NewsAdelpic.twitter.com/YdzvxYJhqF
Czechia will prohibit people who have not been vaccinated from entering public spaces such as restaurants and shops from Monday. Negative Covid-19 tests will no longer be allowed.
Speaking on Wednesday, outgoing Prime Minister Andrej Babis said the country would adopt the so-called Bavarian model from Monday next week, prohibiting those who have not received a Covid-19 vaccine from entering public places. Those who have recently recovered from the virus will be allowed entry.
The country will enter a partial lockdown of the unvaccinated from Monday morning, assuming the restrictions are approved by the cabinet on Thursday.
“We will introduce the Bavarian model from Sunday to Monday. This means that entry to restaurants, service establishments, or mass events will only be allowed for vaccinated or survivors. Those vaccinated with a single dose must have a PCR test,” Babis said on local TV.
The prime minister said that self-testing would be completely cancelled, as he lamented unvaccinated people for clogging up hospitals and preventing treatment reaching those with other illnesses.
“The death toll is rising; the situation is serious. Vaccination is the only solution, there is no other,” he added.
The country is seeing a spike in infections, with a record 22,479 new cases reported on Tuesday.
The Bavarian model refers to strict anti-Covid measures introduced in the southern German state. Markus Soder, the state’s premier, claimed there was no choice but to implement “a kind of lockdown for the unvaccinated,” citing increasing pressure on hospitals and medical staff.
Meanwhile, some two million people in Austria who are yet to receive their Covid shots have been subject to the world’s first lockdown for the unvaccinated, in an effort to bring case numbers down.
While 68% of people are vaccinated in Germany, and 65% in Austria, just over 60% are vaccinated in the Czech Republic.
Protests against renewed Covid-19 restrictions turned violent in The Hague. The unrest comes a day after several demonstrators in another Dutch city, Rotterdam, were injured amid police gunfire.
Seven people were arrested after fierce clashes broke out between law enforcement and anti-lockdown demonstrators in The Hague, the seat of the International Court of Justice (ICJ), on Saturday.
A video shared on social media shows protesters lighting firecrackers that sparked multiple fires, causing the skies in the city to glow an eerie red.
The Hague burns🔥, home of international court of justice, the seat of Dutch cabinet and 3rd largest city in Netherlands pic.twitter.com/8gjqu2sE60
Dutch police reported that five of its officers were injured in the showdown with rioters. One officer was taken to hospital with a knee injury and concussion. Two others “suffered hearing damage,” while another two suffered injuries to their hands.
The chaotic scenes in the Netherlands’ third-largest city unfolded a day after a protest against reimposed Covid-19 restrictions in Rotterdam was marred by violence. Over 50 people were arrested in the city and three were injured after police opened fire in a bid to quell the unrest. Police later claimed that officers were “compelled to shoot at targets” to protect themselves. The three injured protesters remain in hospital, and their condition is unknown.
Protests have swept through a number of Dutch cities after the Netherlands became the first country in Western Europe since summer to go into a partial lockdown last week. Tensions soared further after the government banned New Year’s Eve fireworks displays and the Dutch parliament backed the introduction of the so-called 2G system, which would bar the unvaccinated and those who have not recently recovered from the virus from a long list of public places if introduced.
Think your friends would be interested? Share this story!
Australia’s government could be forced to spend tens of millions in payouts after receiving more than 10,000 compensation claims from people who suffered side effects and loss of income due to Covid-19 vaccines.
Under its no-fault indemnity scheme, eligible claimants can apply for compensation amounts between AU$5,000 (US$3,646) to AU$20,000 (US$14,585) to cover medical costs and lost wages as a result of being hospitalized after getting the shot. The scheme’s online portal is scheduled to be launched next month.
Official figures suggest, however, that over 10,000 people have already indicated their intention to make a claim since registration opened on the health department’s website in September. If each claim was approved, the government could face a bill of at least AU$50 million (US$36.46 million).
There were around 78,880 adverse events to Covid-related vaccination in Australia as of November 7, according to the Therapeutic Goods Administration, which regulates national health products. The majority of side effects were minor, including headaches, nausea, and arm soreness.
Only people who experienced a moderate to significant adverse reaction that resulted in a hospital stay of at least one night are eligible for coverage under the government’s scheme. Those seeking $20,000 or less have to provide proof their claims are vaccine-related – although there has been no information as yet on exactly what evidence would be acceptable.
“Adverse events, even though they happen to a tiny proportion of people, for the people it does impact it’s really quite devastating,” Clare Eves, the head of medical negligence at injury compensation firm Shine Lawyers, told the Sydney Morning Herald.
Among the adverse reactions covered are the blood clotting disorder “thrombosis with thrombocytopenia syndrome (TTS)” linked to the AstraZeneca vaccine and the “myocarditis and pericarditis” heart conditions associated with the Pfizer vaccine. Other reportedly accepted side effects are Guillain-Barré syndrome, a rare neurological condition, and immune thrombocytopenia (excessive bleeding due to low platelet levels).
Claims for over $20,000, including those for vaccine-related deaths, will be assessed by an independent legal panel of legal experts and compensation paid on its recommendations. Nine people have reportedly died after an adverse reaction to one of the three vaccines in the country.
Eves told the Morning Herald that her firm was representing a number of litigants over the vaccine side effects, including several who are not eligible for the scheme.
