As infections are rising again, scientists all around the world are rushing to fight the danger, offering a choice of new treatments and unusual variants of vaccines.
Levels of contagion are setting new records, hospitals are overwhelmed, governments are starting to introduce lockdowns, and not only for unvaccinated people – the picture of the fight against Covid-19 looks quite disappointing. However, there’s still a place for good news: Research teams report positive results while trialling new medicines and vaccine types.
Nasal vaccines
Vaccination will remain one of the most effective tools against Covid-19. As Professor David Dockrell, from the Center for Inflammation Research of the University of Edinburgh, told RT, “vaccines will continue to be a central part of how we control the virus.”
“If we can dampen down the number of infections, and the severity of infections, and also the extent to which the virus can replicate in people when they become infected, then we are slowing down the ability of the virus to change and to mutate,” he explains.
So I think the vaccines still will be a very important part of the preventive strategy. It’s vital that they are available to all the world’s population, irrespective of where people live, and the wealth of the country in which they live.
However, vaccination doesn’t always mean you have to get an injection. For instance, several intranasal Covid-19 vaccines are currently being developed. As the virus gets into the body through the nose, a nasal spray or drops are aimed to produce mucosal immune response and prevent it from getting into the lungs.
In India, a vaccine of this type is already completing Phase 2 of clinical trials. In Russia, a nasal vaccine is undergoing a clinical trial on volunteers. In Thailand, a home-developed product is expected to be trialed on humans next spring. In the US, Universities of Houston and Stanford recently reported good results of their experiments carried out on mice.
Intranasal vaccines can have several potential benefits compared to inoculation.
“They would be easier to use, because they can be self-administered. They wouldn’t need a nurse or clinical settings,” Swedish professor emeritus of epidemiology Marcello Ferrada de Noli explained to RT. As a result, he says, there’s hope that fewer people will be reluctant to be immunized. Not so many of us find it pleasant to get a jab – and after all, there are those who are just afraid of needles. Also, it would be much easier to vaccinate children with nasal substances.
However, what concerns Prof. de Noli the most is the duration of the effect of a vaccine of this type. Still, scientists can’t say for sure whether a nasal substance may completely replace a shot. According to Alexander Gintsburg, the head of Moscow’s Gamaleya Center biomedical research institute, which created the Sputnik V vaccine, the nasal version they are working on would serve for an additional protection against the virus, but would not replace the injections.
Chew the virus away?
A nasal vaccine is not the only one being developed. In summer, it was revealed that Russian Defense Ministry scientists were creating a ‘chewing gum’ vaccine, also targeting the mucosal immune response. Meanwhile, a UK firm announced this month that it would conduct a human trial of a skin patch that uses T-cells to confront the virus. Developers hope it would offer longer-lasting immunity than the existing vaccines. Work on a similar project is being done in the University of Queensland, Australia.
While it all looks so promising, Prof. de Noli warns that it would still take a lot of time until these products become available to the public. “I think that discoveries in this field are a very good thing. But if we say ‘We discovered a new type of vaccine’, people will say ‘Aha, so I’m going to wait’. But we need to vaccinate people now,” he points out.
Improving Covid treatment
Vaccines are not a silver bullet, unfortunately, given the not-so-high level of global immunization and the constantly emerging new strains of the virus. “People might get infected despite having had a vaccine, but I still think the vaccine strategy is going to be central to how we manage this kind of virus going forward,” Prof. Dockrell says. “But we will have other strategies that will be very important. We will have other elements. When we put them all together, it gives us the best opportunity that people can live with coronaviruses, and hopefully, the mortality can be limited to much lower extense than what we’ve sadly seen in the last eighteen months.”
Monoclonal antibodies will be central to the ongoing vaccine strategy, Prof. Dockrell explains. These are the antibodies similar to those the body uses to fight the virus. They are produced in labs and given via infusion or injection to boost the patient’s response against certain diseases. Monoclonal antibody treatment is used for people under a high risk of developing severe infection (including older patients 65+ years old or those with chronic medical conditions). It’s already being used in the US, following last year’s FDA approval. Earlier in November, the European Medicines agency recommended authorizing two monoclonal antibody medicines.
In October, UK’s AstraZeneca reported positive results of a Phase 3 study of its antibody combination, which, according to developers, is highly effective in both prevention and treatment of coronavirus.
Researchers are also working on a possibility to save Covid-infected patients from the so-called ‘cytokine storm’ – a situation when the immune system reacts so intensely that kills not only the virus, but the whole organism itself. A drug to ‘calm the storm’ was registered in Russia this year, and it’s already being used on patients.
Another way to fight Covid-19 is to use antiviral drugs. When the pandemic started, medics had to use something already existing (like anti-influenza Favipiravir) or something being authorized for emergency use (like remdesivir). Now, more than a year on, the work to create a special drug to specifically cure Covid-19 is giving its results. This month, Russia registered its first injectable anti-Covid medicine. A bit earlier, the UK became the first country to approve an antiviral pill produced by the US-based companies Merck and Ridgeback Biotherapeutics. Another American firm, Pfizer, got positive results from trials of its drug of the same kind. Both firms hope that with a drug in the form of a pill it would be easier to treat people at home.
Appreciating all the efforts on the field of developing anti-Covid treatment, Prof. de Noli points out that still, the key issue now is to reduce the spreading of the virus. “The new medicines are developed for people who already got the disease,” he says.
But we need to prevent people from getting the infection, not let them get infected because we have some new medicine that can cure them.
The same idea is echoed by scientists all over the world quoted in plenty of articles dedicated to the medical gains: it’s great to have the treatment, but none of the drugs may substitute vaccination, as first and foremost, humanity has to adopt preventive measures and stop the pandemic.
Vaccination of all Hungarian citizens against Covid-19 is inevitable, PM Viktor Orban has said, stating that even the most hardline anti-vaxxers will ultimately face a choice between dying with the virus and getting a jab.
Speaking to Kossuth radio on Friday, the Hungarian leader lashed out at those reluctant to get vaccinated against coronavirus, branding them a threat “not only to themselves but to all others.”
In the end, everyone will have to be vaccinated; even the anti-vaxxers will realize that they will either get vaccinated or die. So, I urge everyone to take this opportunity.
The EU member state is currently experiencing its fourth wave of coronavirus, Orban stated, blaming the situation on those who had not got vaccinated. “If everybody were inoculated, there would be no fourth wave or it would be just a small one,” the PM claimed.
Apart from urging the unvaccinated to go and finally get their jabs, Orban also promoted booster shots, revealing that he had already taken three doses of a coronavirus vaccine.
“The only thing that protects us from the virus is vaccination. And we are now also seeing, at least the experts are unanimous in saying, that four to six months after the second vaccination, the protective power of the vaccine weakens. Therefore, a third vaccination is justified,” he said.
Hungary has already announced new anti-Covid measures, though somewhat short of the strict measures proposed by the nation’s Medical Chamber on Wednesday. The medical body called for a blanket ban on mass events, and suggested making entry to restaurants, theaters and other indoor venues conditional on bearing a Covid-19 inoculation certificate. Instead, Budapest rolled out compulsory mask wearing for most indoor environments, as well as making booster shots mandatory for all medical workers, starting from Saturday.
A nation of 10 million, Hungary’s total tally of logged Covid cases is hovering just below the one million mark. On Friday, it registered a new daily record, with nearly 11,300 new Covid infections. More than 32,700 people in Hungary have succumbed to the disease over the course of the pandemic.
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Hard-line cleric Ebrahim Raisi won Iran’s presidential election on Saturday in a move that is expected to bolster the conservative legacy of the country’s supreme leader, Ayatollah Ali Khamenei.
The decision is not expected to derail ongoing negotiations aimed at restoring the Joint Comprehensive Plan of Action (JCPOA) nuclear deal, even though Mr. Raisi himself is under US sanctions over accusations of human rights abuses. Many voters stayed away from the polls as the outcome had been predicted for months with many progressive candidates barred from running.
“The Islamic Republic has entered a post-revolutionary dynamic in which a fading revolutionary generation seeks to ensure that the rising political leadership sustains their revolutionary ideals,” says Norman T. Roule, former National Intelligence Manager for Iran at ODNI and Cipher Brief Expert. “The regime’s decision to bar so many candidates and the low turnout make this election a historic embarrassment for the regime and its supporters.”
The Cipher Brief talked with Roule about what the election means and what it doesn’t mean when it comes to relations with the west, the progressive movement within Iran and the election’s impact on the oil markets.
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China has accused the Philippines of breaching its territory, saying two supply ships were blocked by Beijing’s coast guard as they approached a disputed shoal. Manila protested over the run-in, citing its own claim to the area.
The two Philippines vessels “trespassed” into waters near the Nansha island chain – also known as the Spratly Islands – on November 16, Foreign Ministry spokesman Zhao Lijan told reporters on Friday, noting that they entered the area “without China’s consent.”
“Chinese coast guard vessels performed official duties in accordance with law and upheld China’s territorial sovereignty and maritime order,” Zhao said, adding that the area is now “generally tranquil” and that the two countries are in communication about the encounter.
The comments from Beijing come just one day after Manila first publicized the incident, with the Philippines Foreign Affairs Secretary Teodoro Locsin claiming Chinese vessels fired water cannon on the two supply boats and forced them to abandon their mission near a disputed shoal in the Spratlys. He called on China to “back off” and “take heed” of Philippines claims to the region.
While both countries regard the Ayungin shoal – alternatively referred to as the Second Thomas or Renai Jiao shoal – as their own territory, The Hague’s Permanent Court of Arbitration settled the dispute in the Philippines’ favor in 2016. However, despite that ruling, as well as the fact that Manila has maintained a presence on the shoal since 1999, Beijing has not abandoned its claims to the area.
Scientists have used an AI tool to identify which animals are most likely to contract and spread mutated versions of Covid-19. The model highlighted both pets and wild animals as likely reservoirs for the virus.
Using information about their habitats and various biological traits, researchers at the Cary Institute of Ecosystem Studies in New York developed the machine learning tool to figure out which animals had the particular ACE2 protein that the coronavirus was most likely to latch onto.
Out of 5,400 tested, the scientists narrowed it down to 540 mammalian species.
Some of its predictions have been previously documented as transmission risks, for instance, dogs, cats and bats, while farm animals like pigs and exotic zoo animals were surprise additions.
Other expected additions are minks, Sunda pangolins, and 35 species of bats – which are together ranked among the top 10% of animals most likely to spread the virus, in line with lab results.
The study, published in the Proceedings of the Royal Society journal, also ranked water buffalo, a number of primates, including gorillas and 76 rodent species as being more susceptible to infection.
The researchers taught the AI to identify patterns between rates of transmission and some 60 ecological and biological traits collected by earlier studies, including the overlap between the animal and human habitats as well as their respective lifespans, diets, and sizes.
Previously, the specific amino acid sequences had only been mapped out in around 300 species, including about 143 mammals — and figuring out which ones are more prone to infection is key to predicting the spread of the virus, researchers said.
Arinjay Banerjee at the University of Saskatchewan in Canada told the New Scientist that the results will help researchers “track viral infections and the possible emergence of animal-adapted coronavirus variants” around the world. Barbara Han, who led the study, said predictions needed to be followed up with systematic surveillance and lab studies.
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Austria will introduce a full lockdown that could last for three weeks on Monday in an attempt to tackle a new wave of Covid-19 infections. The government has also ordered the entire population to get vaccinated from February 1.
On Friday, conservative Chancellor Alexander Schallenberg told a news conference that a complete lockdown of the nation would begin on Monday and last for an initial 10 days.
He stated that the restrictions could be extended if infection rates did not start to fall, but he insisted the lockdown would not exceed 20 days.
The measures concern the entire Austrian population. The government has already imposed a partial lockdown on the unvaccinated in an effort to reduce hospitalization rates amid a surge in Covid-19 cases.
When the full lockdown ends, restrictions will remain in place for the unvaccinated.
Schallenberg’s announcement came after a meeting of nine state governors, two of whom had already vowed to introduce full lockdowns in their regions on Monday, in the western province of Tyrol.
The chancellor also announced that vaccinations would be mandatory from February 1. “We haven’t been able to convince enough people to vaccinate. For too long, I and others have assumed that you can convince people to get vaccinated,” he added, giving his rationale for the mandate.
Schallenberg said he lamented the political forces, radical opposition, and fake news fighting against vaccination.
Austria has one of the lowest vaccination rates in western Europe, with only 65% inoculated against the deadly virus according to data from Johns Hopkins university.
Infection rates are almost among the highest on the continent. The seven-day incidence rate stands at 971.5 per 100,000 people.
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The Chinese foreign ministry has lashed out at Lithuania after the small Baltic Sea nation approved the opening of the Taiwan Representative Office in Vilnius. Beijing says it undermines its One China policy.
Beijing was disappointed that Lithuania had proceeded to grant Taiwan permission to open its ‘representative office’ in Vilnius despite “China’s strong opposition and repeated persuasion,” Chinese foreign ministry spokesman Zhao Lijian said at a press briefing on Friday. Taiwan had opened its mission in Vilnius the previous day.
Zhao called the move a violation of the One China principle, which he said is undermining China’s sovereignty and territorial integrity, while grossly interfering in its internal affairs. The spokesman reminded Lithuania that Taiwan is an inalienable part of China’s territory and the Beijing government has sole legal authority.
As to what necessary measures China will take, you may wait and see. The Lithuanian side shall reap what it sows.
In a “stern warning” to the Taiwanese authorities, Zhao then added that “seeking ‘Taiwan independence’ by soliciting foreign support is a totally misguided attempt that is doomed to fail.”
In August, Lithuania announced that the diplomatic outpost would be named the “Taiwan Representative Office,” angering China. Taiwan’s diplomatic branches – in countries that have de facto relations with the island’s authorities – are normally called “Taipei Economic and Cultural Offices.”
China demanded that Lithuania recall its ambassador from China, which it did. Beijing then withdrew its envoy to the Baltic state.
Chinese officials have repeatedly called on Western nations, notably the UK and US, to stop interfering in Beijing’s internal affairs, stressing that they consider Taiwan to be part of China.
AstraZeneca has announced that its preventative antibody cocktail offers 83% protection against symptomatic Covid-19 for at least six months, making it more effective than its own vaccine.
In a statement on Thursday, AstraZeneca cemented its lead in the race to develop and market a preventative Covid-19 drug, which is delivered as a shot in the arm.
The drug, named AZD7442, reduces the risk of symptomatic Covid-19 by 83% over the course of six months, according to data from a trial in which participants were given one 300mg dose. There were no deaths or severe infections recorded within the trial group, it said.
A separate trial showed the drug reduced the risk of severe Covid-19 or death by 88% when administered within three days of the onset of symptoms.
“These new data add to the growing body of evidence supporting AZD7442’s potential … We are progressing regulatory filings around the world and look forward to providing an important new option against SARS-CoV-2 [Covid-19] as quickly as possible,” AstraZeneca Executive Vice President Mene Pangalos said in the statement.
The Anglo-Swedish firm has agreed to supply the US government with 700,000 doses of AZD7442 if the Food and Drug Administration grants it emergency use, which AstraZeneca requested on October 5. The firm has similar agreements with other nations.
The drug is created using a combination of two antibodies originating from immune B-cells donated by a recovering Covid-19 patient.
The treatment could be used in people who are known not to respond well to vaccines, such as cancer patients. Around 2% of people are considered to be at risk of not creating enough antibodies following the administration of a Covid-19 vaccine.
Based on the numbers, the drug appears to be more effective than the firm’s first-generation Covid-19 vaccine. Britain’s Zoe Covid study showed the effectiveness of the vaccine dropped to around 67% after four to five months.
Taiwan’s president unveiled the country’s combat wing of advanced US-made F-16 fighters in a ceremony on Thursday, showing its new Air Force capabilities against mainland China.
The event, held at an air base in the southern Taiwanese city of Chiayi, saw the island commission the first combat wing of F-16 fighters, developed with US support.
The F-16 upgrades, costing T$110 billion (USD$3.95 billion), have been jointly completed by American manufacturer Lockheed Martin Corp and Taiwan’s Aerospace Industrial Development Corp.
Taiwan’s leader, Tsai Ing-wen, touted the new F-16s as ensuring that the island’s defenses would be “even stronger” in the face of increased tensions with China.
In October, Beijing sent a record 150 warplanes into Taiwan’s air defense identification zone (ADIZ) in four straight days of incursions. Over the past year, China’s Air Force has increased military activity in and around Taiwan’s ADIZ, according to Taipei.
Despite Taipei claiming it does not want to provoke a confrontation with China, the island’s president pledged that it will “do whatever it takes to defend itself.”
China has rejected claims that it is provoking conflict in Taiwan, which it sees as an integral part of its country, accusing America of “inflating” the island separatist movement, firmly stating that “Taiwan independence” is a dead end and Beijing will “take all steps” to ensure the island remains under its control. In recent years, China has become increasingly assertive about reuniting its wealthy island neighbor with the mainland.
The successful F-16 development process has been seen by Taiwan as the latest visible sign of the military partnership between Washington, DC and Taipei. Back in 2019, America approved an $8 billion sale of F-16s to Taiwan, which would bring the total number of jets in the island’s fleet to 200.
During the event, the Taiwanese president praised America for remaining steadfast in its cooperation with the island despite opposition from China. “As long as we adhere to the values of democracy and freedom, there will be more like-minded countries standing on the same front with us,” Tsai said alongside US diplomat Sandra Oudkirk.
In 2019, after the US and Taiwan agreed to upgrade the F-16 fighter jets, then-Foreign Ministry spokesperson Geng Shuang threatened to sanction American firms unless the deal was halted. Beijing opposed the military partnership between Taipei and Washington, DC, arguing that the sale violated international law, harmed relations between the countries, and breached the One China policy, which America recognizes.
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Protests against renewed Covid-19 restrictions turned violent in The Hague. The unrest comes a day after several demonstrators in another Dutch city, Rotterdam, were injured amid police gunfire.
Seven people were arrested after fierce clashes broke out between law enforcement and anti-lockdown demonstrators in The Hague, the seat of the International Court of Justice (ICJ), on Saturday.
A video shared on social media shows protesters lighting firecrackers that sparked multiple fires, causing the skies in the city to glow an eerie red.
The Hague burns🔥, home of international court of justice, the seat of Dutch cabinet and 3rd largest city in Netherlands pic.twitter.com/8gjqu2sE60
Dutch police reported that five of its officers were injured in the showdown with rioters. One officer was taken to hospital with a knee injury and concussion. Two others “suffered hearing damage,” while another two suffered injuries to their hands.
The chaotic scenes in the Netherlands’ third-largest city unfolded a day after a protest against reimposed Covid-19 restrictions in Rotterdam was marred by violence. Over 50 people were arrested in the city and three were injured after police opened fire in a bid to quell the unrest. Police later claimed that officers were “compelled to shoot at targets” to protect themselves. The three injured protesters remain in hospital, and their condition is unknown.
Protests have swept through a number of Dutch cities after the Netherlands became the first country in Western Europe since summer to go into a partial lockdown last week. Tensions soared further after the government banned New Year’s Eve fireworks displays and the Dutch parliament backed the introduction of the so-called 2G system, which would bar the unvaccinated and those who have not recently recovered from the virus from a long list of public places if introduced.
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