Scientists have used artificial intelligence to “predict” formulas for new designer drugs, with the stated goal of helping to improve their regulation. The AI generated formulas for nearly nine million potential new drugs.

Researchers with the University of British Columbia (UBC) used a deep neural net for the job, teaching it to make up chemical structures of potential new drugs. According to their study, released this week, the computer intelligence fared better at the task than the scientists had expected.

The research team used a database of known designer drugs – synthetic psychoactive substances – to train the AI on their structures. The market for designer drugs is ever-changing, since their manufacturers are constantly tweaking their formulas to circumvent restrictions and produce new “legal” substances, while cracking their structure takes months for law enforcement agencies, the researchers said.

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“The vast majority of these designer drugs have never been tested in humans and are completely unregulated. They are a major public-health concern to emergency departments across the world,” one of the researchers, UBC medical student Dr. Michael Skinnider has said.

After its training, the AI was able to generate some 8.9 million potential designer drugs. Afterwards, researchers ran a data sheet of some 196 new drugs, which had emerged in real life after the model was trained, and found that more than 90% of these have been already predicted by the computer.

“The fact that we can predict what designer drugs are likely to emerge on the market before they actually appear is a bit like the 2002 sci-fi movie, Minority Report, where foreknowledge about criminal activities about to take place helped significantly reduce crime in a future world,” senior author Dr. David Wishart, a professor of computing science at the University of Alberta, has said.

Identifying completely unknown substances remains an issue for the AI, the research team has noted, but they hope it might potentially help with that task, since the computer was also able to predict which formulas of designer drugs were more likely to be created and hit the market. The model “ranked the correct chemical structure of an unidentified designer drug among the top 10 candidates 72 percent of the time,” while throwing in spectrometry analysis, which is an easily obtained measurement, bumped the accuracy to some 86%.

“It was shocking to us that the model performed this well, because elucidating entire chemical structures from just an accurate mass measurement is generally thought to be an unsolvable problem,” Skinnider stated.

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An official inquiry has found that Germany’s justice system was staffed with former Nazis for decades after the Second World War, At one point, three out of four top officials at the prosecutor’s office were former party members.

Released on Thursday, the 600-page report was compiled by historian Friedrich Kiessling and legal scholar Christoph Safferling, and covers the Cold War period running from the early 1950s until 1974. The work was commissioned by the federal prosecutor’s office. 

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The Federal Ministry of Justice in Berlin © De-okin
Over 50% of W. Germany’s senior justice ministry officials in 1950-70s were ex-Nazis – govt report

The researchers found that, at one point during the 1950s, roughly three in four top officials in the federal prosecutor’s office had been members of the Nazi Party. It took until 1972 before former Nazis were no longer in the majority in that office, and until 1992 before the judicial system had been fully purged of ex-members of the fascist party.

“There was no break, let alone a conscious break, with the Nazi past,” the researchers said of the situation. 

Presenting the inquiry’s findings, state secretary at the justice ministry Margaretha Sudhof said the country has “long remained blind” to the presence of ex-Nazis in senior positions after the end of the Second World War.

“On the face of it they were highly competent lawyers… but that came against the backdrop of the death sentences and race laws in which they were involved,” Sudhof commented. 

In a statement about the study’s publication, Justice Minister Christine Lambrecht said she welcomed “the fact that the Federal Prosecutor’s Office is also grappling with its troubled past and is shedding more light on its own Nazi entanglements in the post-war period.”

The federal prosecutor’s office is Germany’s highest prosecutorial authority, responsible for pursuing those who violate international law and commit alleged crimes relating to state security. 

The latest study follows an earlier report published in 2016, which stated that in 1957 – more than a decade after the war had ended – 77% of senior officials in the justice ministry were former Nazis. At the time of that publication, then-Justice Minister Heiko Maas stated that the “Nazi-era lawyers went on to cover up old injustice rather than to uncover it, and thereby created new injustice.”

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NEW YORK, Nov 19 (IPS) – A week has gone by since COP 26 with 197 Parties ended in the Scottish city of Glasgow on extended time last Saturday. Climate change which covers wide array of issues affecting all living beings engaged the people around the world for COP 26 in a way never experienced since COP1 was held in Berlin in 1995.

Read the full story, “Glossing Over in Glasgow – Some Thoughts on COP26”, on globalissues.org

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Covid-battered global supply chains are being threatened by organized criminals, including drug cartels and con artists posing as legit suppliers, a new study has found, warning that the situation is set to get worse.

The international supply chain woes amid the Covid-19 pandemic are highlighted in a new annual report, released this week by the British Standards Institution (BSI).

The document, titled the ‘Supply Chain Risk Insights Report’, highlights Covid’s impact on supply chains, with the experts also warning that organized crime has increasingly preyed on this crucial area during the pandemic. On multiple instances, criminals were posing as legitimate logistics providers, stealing goods during shipment.

“I’m seeing a significant number of false suppliers acting as genuine potential suppliers in supply chain logistics provision – warehousing distribution, distribution centres, transportation companies – and actually, they are criminal groups trying to infiltrate the logistics supply chain,” said David Fairnie, BSI’s principal consultant in supply chain security. He urged producers to “continuously monitor” the supply chain and to not immediately trust new logistics providers – especially those contacted only remotely.

So, arguably today more than ever, you do need to know your suppliers. So far in 2021, BSI has noted this issue of fake carriers in an increasing number of countries in both the Americas and Europe.

Criminals have apparently been trying to steal goods in various ways, with phony truck drivers loading up items and taking off with them, while conmen “posing as legitimate employees” have reportedly been observed lurking around delivery destinations to steal cargo.

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At the same time, the report found that trade in illicit goods has also been on the rise lately, with the illegal drug industry in particular appearing to flourish. While the supply chain for drug cartels, which require large amounts of assorted chemicals to produce narcotics, was disrupted due to the pandemic lockdowns and border closures impacted trafficking routes, organized crime quickly overcame these problems, the BSI noted.

“Drug cartels around the world did not miss a beat,” Chris Tomas, BSI lead intelligence analyst, said.

While many cartels shifted their production towards synthetic drugs, namely amphetamine, amid the pandemic, the apparent “lack of eradication of coca crops in Latin American countries” also remains an issue, the BSI said. The flow of cocaine has grown over the past year and is expected to increase even further, the organization warned.

“The numbers and quantities of cocaine seizures in Europe increased steadily in 2020 and 2021 and are expected to continue to rise in 2022,” the report reads.

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A stream literally flowing with booze emitting a strong beery odor has been discovered in one of the tropical islands of Hawaii. Its waters have been apparently contaminated with alcohol after a leak at a beverage warehouse.

A small river with a distinctive alcoholic smell was recently found on the island of Oahu, some 15 miles (24 kilometers) away from Honolulu, Hawaiian capital. Its waters have been flowing through the Waipio valley and even turned into a 100-foot (30 meters) waterfall on their way.  

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The stream caught the attention of local environmental activists, who noticed the smell in the area.

The other day we came here you would think it was a beer pub that hadn’t opened its doors for three or four days,” activist Carroll Cox told local Hawaii News Now. She also contacted the Department of Health about the issue.

Local media took samples from the unusual stream and had them checked at a private laboratory. It tested positive for alcohol, containing 1.2% percent of the substance in its waters – nearly a quarter the content in regular beer and strong enough to cause a buzz.

Local health authorities got involved, and an investigation into the source of contamination was launched. It was learned that the stream was coming from a drain pipe that was traced back to a warehouse of Hawaii’s largest liquor distributor, Paradise Beverages. Its representatives told local media they were working with officials to eliminate a possible spill, with the booze river apparently closing its free drinks service.

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Reuters has apologized for its poor choice of photo to illustrate a story about a monkey brain study that was deemed offensive and racist in China.

On Thursday, Reuters published a story titled “Monkey-brain study with link to China’s military roils top European university.” The report was about a Chinese professor studying how a monkey’s brain functions at extreme altitude.

The study was done with the help of Beijing’s People’s Liberation Army (PLA) with the aim of developing new drugs to prevent brain damage, Reuters said.

The news agency promoted the story on Twitter with a photo of smiling Chinese soldiers in an oxygen chamber.

The tweet prompted outrage in China, with people calling it racist on social media. Reuters responded on Friday night by deleting the original tweet because the photo of Chinese soldiers was unrelated to the story and “could have been read as offensive.”

“As soon as we became aware of our mistake, the tweet was deleted and corrected, and we apologize for the offense it caused,” Reuters said in a statement to the Global Times, China’s state-run newspaper.

It was not the first time the leading Western news agency had run into trouble in China. In July, the Chinese Embassy in Sri Lanka criticized Reuters for using a photo of Chinese weightlifter and Tokyo 2020 Olympics gold medalist Hou Zhihui that the country’s state media described as “ugly” and “disrespectful to the athlete.”

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General Joseph L. Votel (Ret.) joined BENS as CEO & President in January 2020 following a 39-year military career where he commanded special operations and conventional forces at every level; last serving as the Commander of U.S. Central Command (CENTCOM) where he was responsible for U.S. and coalition military operations in the Middle East, Levant, and Central and South Asia. General Votel’s career included combat in Panama, Afghanistan, and Iraq and he led the 79-member coalition that successfully liberated Iraq and Syria from the Islamic State Caliphate. General Votel preceded his assignment at CENTCOM with service as the Commander of U.S. Special Operations Command and the Joint Special Operations Command.

The Cipher Brief:  Did you ever envision that the U.S. would pull out so quickly or completely leaving the Afghan military on its own without U.S. air support?  

General Votel: I did not anticipate this during my time – but once the President sets a hard departure date – then a fast withdrawal is inevitable.  No Commander wants to accept unnecessary risk with troops on the ground when you are up against a clearly articulated departure date.

The Cipher Brief: Intelligence assessments wildly missed the mark on how fast Kabul would fall, what factors contributed most directly to this? 

General Votel: Certainly, the departure of our own capabilities is a big part of this; the lack of direct contact with Afghan leaders is another important factor; and, of course, once it was clear that we were departing (and took our Commander out) — we lost priority and access with our normal and reliable Afghan intelligence sources.

The Cipher Brief: U.S. personnel are facing a deteriorating security situation at the Kabul airport while U.S. forces are still deploying for the contingency operation, another sign that the administration underestimated how fast the Taliban would reach Kabul. The U.S. could have chosen to slow the Taliban advance using airpower, why didn’t it happen, do you think? 


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General Votel: I think it is very clear that this was no longer a priority for our Government.  The mission right now, at least articulated over the weekend, is about supporting evacuation of the diplomats and helping with the departure of those Afghans who assisted the US and meet the criteria for evacuation.  While I don’t know this for certain — I believe what we were trying to do with over the horizon air support in a rapidly developing situation, was not optimal or overly effective.  It doesn’t seem to have done much – if anything.

The Cipher Brief: The U.S. has allowed U.S. supplied military hardware, weapons and technology to fall into the hands of the Taliban, a group responsible for the deaths of U.S. personnel and thousands of innocent Afghans.  The U.S. government holds private citizens and corporations accountable for far lesser violations of export violations involving dual-use technology or military equipment, etc.  How should Americans think about this situation now, where the Taliban will use equipment, paid for the by the U.S. taxpayer, to potentially perpetrate acts of violence against U.S. interests, and erode democratic values that the U.S. tried to introduce to Afghanistan?  

General Votel: Not sure on this.  Unfortunately, it is not the first time we have seen this — remember ISIS in 2014, in Mosul?  I suspect these will be more trophy pieces than they will be hard military capability – with the exception of small arms, mortars, and artillery.  Most of this will be difficult for the Taliban to sustain – and they probably prefer their own gear, anyway.

The Cipher Brief:  There is a lot of anger among the national security community right now.  What would you say to individuals who have suffered because of the U.S. role in Afghanistan, who may be feeling anger and rage?  

General Votel: I can’t really comment on anger in the national security community — I am sure that exists, but the sentiment that seems more strong to me, is disappointment.  No one wants what we are seeing now.  I think most security professionals can accept a decision to depart by the Commander in Chief — that is well within his authority, and everyone understands this; what is harder to accept is the manner in which this happened, and how it has played out.  It was hard for me to watch Taliban sitting at a conference table that I once sat at with the Afghan President.  In a number of public engagements, I have participated in lately – people have asked me if this whole effort was a waste.  My response has been consistent.  American military personnel, members of the IC and the diplomatic corps conducted themselves honorably throughout this war.  They responded when the Nation called and did their best for our Country, each other, and the Afghan people.  There will be plenty of time to place the blame – but the vast, vast majority of Americans who participated in some aspect of the Afghan War did so nobly and to the best of their ability.  We should not lose sight of this.  That this did not turn out the way we all hoped — is not their fault … and I would not want anyone (especially families of our wounded and killed) to think these efforts were in vain.  That is not how I thought about them at the time, and it is not how I think about them now.  They answered when the Nation called.

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Hard-line cleric Ebrahim Raisi won Iran’s presidential election on Saturday in a move that is expected to bolster the conservative legacy of the country’s supreme leader, Ayatollah Ali Khamenei.

The decision is not expected to derail ongoing negotiations aimed at restoring the Joint Comprehensive Plan of Action (JCPOA) nuclear deal, even though Mr. Raisi himself is under US sanctions over accusations of human rights abuses.  Many voters stayed away from the polls as the outcome had been predicted for months with many progressive candidates barred from running.

The Islamic Republic has entered a post-revolutionary dynamic in which a fading revolutionary generation seeks to ensure that the rising political leadership sustains their revolutionary ideals,” says Norman T. Roule, former National Intelligence Manager for Iran at ODNI and Cipher Brief Expert. “The regime’s decision to bar so many candidates and the low turnout make this election a historic embarrassment for the regime and its supporters.”

The Cipher Brief talked with Roule about what the election means and what it doesn’t mean when it comes to relations with the west, the progressive movement within Iran and the election’s impact on the oil markets.


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Amid a surge in Covid-19 cases, Gibraltar has canceled official Christmas events and “strongly” discouraged people from hosting private gatherings for four weeks. Gibraltar’s entire eligible population is vaccinated.

The government of Gibraltar recently announced that “official Christmas parties, official receptions and similar gatherings” have been canceled, and advised the public to avoid social events and parties for the next four weeks. Outdoor spaces are recommended over indoor ones, touching and hugging is discouraged, and mask wearing is advised.

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“The drastic increase in the numbers of people testing positive for Covid-19 in recent days is a stark reminder that the virus is still very prevalent in our community and that it is the responsibility of us all to take every reasonable precaution to protect ourselves and our loved ones,” Health Minister Samantha Sacramento said. 

Gibraltar, a tiny British Overseas Territory sharing a land border with Spain, has seen an average of 56 Covid-19 cases per day over the last seven days, up from fewer than 10 per day in September. The rise in cases, described by the government as “exponential,” comes despite Gibraltar having the highest vaccination rate in the world.

More than 118% of Gibraltar’s population are fully vaccinated against Covid-19, with this figure stretching beyond 100% due to doses given to Spaniards who cross the border to work or visit the territory every day. Masks are still required in shops and on public transport. 

The initial vaccine campaign on the British outpost came to a conclusion in early spring 2021, with a large proportion of the population fully inoculated against Covid-19. It became one of the first places in Europe to reduce restrictions following a winter of lockdowns, in what was dubbed ‘Operation Freedom’.

Gibraltar is currently doling out booster doses to the over-40s, healthcare workers, and other “vulnerable groups,” and administering vaccines to children aged between five and 12.

Similarly well-vaccinated countries have also reported surges in Covid-19 infections recently. In Singapore, where 94% of the eligible population have been inoculated, cases and deaths soared to record highs at the end of October, and have since subsided slightly. In Ireland, where around 92% of the adult population is fully vaccinated, cases of Covid-19 and deaths from the virus have roughly doubled since August.

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