Controversial agriculture laws that saw farmers across India protesting for over a year are going to be rolled back, Prime Minister Narendra Modi has unexpectedly announced.

“I want to tell the country that we have decided to repeal the three farm laws,” Modi said in a televised address on Friday, which local media described as “stunning.”

The Indian parliament will complete the constitutional process of repealing the agricultural legislation in late November, he added.

However, the PM again defended the divisive legislation, saying that the reform of the sector, which accounts for some 15% of India’s $2.7 trillion economy, was actually aimed at supporting the country’s small farmers.

Whatever I did was for farmers. What I am doing is for the country.

“Maybe something was lacking in our efforts, which is why we couldn’t convince some farmers about the laws,” Modi acknowledged.

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Farmers block railway tracks as part of protests against farm laws during nationwide protests, in Sonipat, northern state of Haryana, India, September 27, 2021. © Reuters / Anushree Fadnavi
Indian farmers return to hold nationwide protests against last year’s agriculture laws

The laws, which were introduced last September, allowed farmers to sell their crops outside of the government-regulated wholesale markets, in which they were guaranteed a minimum price.

The government argued that it would see them earning more, but growers feared that that move would, on the contrary, cause a drop in prices and make them hostages to large corporations.

Thousands of farmers joined the protests against what they called “black laws,” and some rallies turned violent. A year later, many demonstrators remain camped along roads outside the capital New Delhi.

And the farmers aren’t planning on going home just yet, with one of their leaders saying on Twitter: “We will wait for parliament to repeal the laws.”

Modi’s concession to the protesters may have been unexpected, but it comes several months ahead of elections in India’s most populous state of Uttar Pradesh, as well as two other northern states with large rural populations.

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The planned introduction of chemical castration for serial rapists in Pakistan has been dropped due to objections from experts in Islamic law, who said such punishment would be counter to Sharia.

The controversial clause in a bill amending criminal law in Pakistan was dropped before the National Assembly voted on it on Wednesday, a parliament official said on Friday. If it were passed, it would have been unconstitutional, Parliamentary Secretary for Law and Justice Maleeka Bokhari explained. The basic law of the country requires all its laws to be in line with the Sharia and the Koran.

Bokhari said the decision to drop the clause was taken due to objections from the Council of Islamic Ideology, a constitutional body that advises the government of Pakistan on the intricacies of Islamic law.

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© publicdomainpictures.net
Outrage as teen’s rapist spared jail time

The bill amends Pakistan’s Penal Code and Criminal Procedure Code to streamline investigations and prosecutions of sexual crimes as part of wider anti-rape reform. Some conservative lawmakers vocally argued against the castration clause as the piece of legislation was moving towards approval. Senator Mushtaq Ahmed from the Islamist Jamaat-i-Islami party argued that rapists should be hanged publicly, while castration was never mentioned in Sharia.

A separate bill also approved by the parliament on Wednesday introduces a system of special regional investigators for rape allegations to be appointed by the prime minister, as well as new protections for victims, and punishments for officials who fail to investigate their complaints properly. Among other things, it makes evidence that a victim is “generally of immoral character” inadmissible in court.

The reform is necessary because currently deterrence of sexual crimes in Pakistan is undermined by “poor investigation, archaic procedures and rules of evidence and delay in the trial,” the bill said.

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People who live in the big cities are definitely masters of eavesdropping. Sometimes they can’t help it, accidentally overhearing conversations from complete strangers can be so funny, it’s hard not to share them with someone else. And here comes the fittingly named Instagram account Overheard San Francisco that’s dedicated to sharing the funniest eavesdropped interactions in San Francisco and the Bay area. Scroll down to see the funniest examples!

Funny conversation overheard in San Francisco.

Funny conversation overheard in San Francisco.

Funny conversation overheard in San Francisco.

Funny conversation overheard in San Francisco.

Funny conversation overheard in San Francisco.

Funny conversation overheard in San Francisco.

Funny conversation overheard in San Francisco.

Funny conversation overheard in San Francisco.

Funny conversation overheard in San Francisco.

Funny conversation overheard in San Francisco.

Funny conversation overheard in San Francisco.

Funny conversation overheard in San Francisco.

Funny conversation overheard in San Francisco.

Funny conversation overheard in San Francisco.

Funny conversation overheard in San Francisco.

Funny conversation overheard in San Francisco.

Funny conversation overheard in San Francisco.

Funny conversation overheard in San Francisco.

Funny conversation overheard in San Francisco.

Funny conversation overheard in San Francisco.

Funny conversation overheard in San Francisco.

Funny conversation overheard in San Francisco.

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The EU’s drug regulator has backed the emergency use of Merck’s pill for the treatment for clinically vulnerable Covid-19 patients as cases surge across the continent.

On Friday, the European Medicines Agency (EMA) “issued advice” backing the emergency use of the drug developed by Merck in collaboration with Ridgeback Biotherapeutics, although it has not yet been authorized by national authorities.

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© Reuters / Piroschka van de Wouw
EMA green lights new Covid treatments

In a statement, the drug regulator said the medicine called Lagevrio – also known as molnupiravir or MK 4482 – “can be used to treat adults with Covid-19 who do not require supplemental oxygen and who are at increased risk of developing severe Covid-19.

It said the treatment should be administered as soon as possible after Covid-19 is diagnosed and within five days of the start of symptoms. The medicine should be taken twice a day for a period of five days.

The EMA listed the potential side effects of the capsules, including mild or moderate diarrhea, nausea, dizziness and headache. The treatment is not recommended for pregnant women.

The watchdog announced earlier on Friday that it had begun reviewing Pfizer’s medicine Paxlovid for Covid-19 with the same goal “to support national authorities” who may decide on its early use prior to marketing authorization in light of rising cases and deaths in Europe.

On Friday, Austria announced it would enter a new nationwide lockdown from Monday and make vaccination mandatory, while Germany’s health authorities claimed the country had turned into “one big outbreak.”

Both Pfizer and Merck have requested approval for their coronavirus medicines from the US Food and Drug Administration, but it is unclear when it might be granted.

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Protests against renewed Covid-19 restrictions turned violent in The Hague. The unrest comes a day after several demonstrators in another Dutch city, Rotterdam, were injured amid police gunfire.

Seven people were arrested after fierce clashes broke out between law enforcement and anti-lockdown demonstrators in The Hague, the seat of the International Court of Justice (ICJ), on Saturday.

A video shared on social media shows protesters lighting firecrackers that sparked multiple fires, causing the skies in the city to glow an eerie red.

In another clip, a group of protesters could be seen knocking down a traffic pole fitted with a surveillance camera.

Dutch police reported that five of its officers were injured in the showdown with rioters. One officer was taken to hospital with a knee injury and concussion. Two others “suffered hearing damage,” while another two suffered injuries to their hands.

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A burned electric scooter is seen after an anti-lockdown protest in Rotterdam, Netherlands, November 19, 2021 © AFP / Jeffrey Groeneweg
Lockdown protest described as ‘orgy of violence’

The chaotic scenes in the Netherlands’ third-largest city unfolded a day after a protest against reimposed Covid-19 restrictions in Rotterdam was marred by violence. Over 50 people were arrested in the city and three were injured after police opened fire in a bid to quell the unrest. Police later claimed that officers were “compelled to shoot at targets” to protect themselves. The three injured protesters remain in hospital, and their condition is unknown.

Protests have swept through a number of Dutch cities after the Netherlands became the first country in Western Europe since summer to go into a partial lockdown last week. Tensions soared further after the government banned New Year’s Eve fireworks displays and the Dutch parliament backed the introduction of the so-called 2G system, which would bar the unvaccinated and those who have not recently recovered from the virus from a long list of public places if introduced.

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The Swedish government has announced plans to introduce mandatory Covid-19 passes starting next month, amid rising infection rates in Europe. The passes will be required to attend any indoor event with 100 or more participants.

The upcoming introduction of mandatory coronavirus vaccine passes was announced by Health Minister Lena Hallengren on Wednesday.

Citing the ongoing surge in coronavirus cases across Europe – which has not hit the country itself yet – the minister stressed the need to be ready for the new wave of infections, projected to reach Sweden mid-December.

“The spread is increasing in Europe. We haven’t seen it yet in Sweden, but we are not isolated,” Hallengren told a news conference. “We need to be able to use vaccination certificates.”

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© Getty Images / picture alliance
German media reveals jail terms for fake Covid certificates

Starting from December 1, the documents confirming a person’s vaccination status will be a requirement to enter any indoor event with 100 or more people in attendance. Sweden already boasts high vaccination rates, with 85% of its citizens aged over 16 having received at least one dose of a Covid-19 vaccine. Over 81% have received two shots or more, public health data shows.

Earlier in the day, the country’s health authorities backtracked on a highly controversial decision to stop testing fully vaccinated people who showed symptoms of Covid. The recommendation was rolled out in October, leading to a 35% decline in Covid-19 tests taken.

“The Public Health Agency has decided to recommend that the regions offer testing to everyone who is 6 years and older who gets symptoms that may be COVID-19,” the health authority said in a statement.

Sweden bucked the trend among European governments in its approach to handling the pandemic, electing not to impose widespread lockdowns. Having relied primarily on voluntary measures and social distancing, the country displayed several times higher death rates per capita than its Nordic neighbors, though it still fared better than many European countries, registering some 1.18 million cases and just over 15,000 coronavirus deaths since the beginning of the pandemic.

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A Roadmap for AI in the Intelligence Community

(Editor’s Note: This article was first published by our friends at Just Security and is the fourth in a series that is diving into the foundational barriers to the broad integration of AI in the IC – culture, budget, acquisition, risk, and oversight.  This article considers a new IC approach to risk management.)

OPINION — I have written previously that the Intelligence Community (IC) must rapidly advance its artificial intelligence (AI) capabilities to keep pace with our nation’s adversaries and continue to provide policymakers with accurate, timely, and exquisite insights. The good news is that there is strong bipartisan support for doing so. The not-so-good news is that the IC is not well-postured to move quickly and take the risks required to continue to outpace China and other strategic competitors over the next decade.

In addition to the practical budget and acquisition hurdles facing the IC, there is a strong cultural resistance to taking risks when not absolutely necessary. This is understandable given the life-and-death nature of intelligence work and the U.S. government’s imperative to wisely execute national security funds and activities. However, some risks related to innovative and cutting-edge technologies like AI are in fact necessary, and the risk of inaction – the costs of not pursuing AI capabilities – is greater than the risk of action.

The Need for a Risk Framework

For each incredible new invention, there are hundreds of brilliant ideas that have failed. To entrepreneurs and innovators, “failure” is not a bad word. Rather, failed ideas are often critical steps in the learning process that ultimately lead to a successful product; without those prior failed attempts, that final product might never be created. As former President of India A.P.J. Abdul Kalam once said, “FAIL” should really stand for “First Attempt In Learning.”

The U.S. government, however, is not Silicon Valley; it does not consider failure a useful part of any process, especially when it comes to national security activities and taxpayer dollars. Indeed, no one in the U.S. government wants to incur additional costs or delay or lose taxpayer dollars. But there is rarely a distinction made within the government between big failures, which may have a lasting, devastating, and even life-threatening impact, and small failures, which may be mere stumbling blocks with acceptable levels of impact that result in helpful course corrections.


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As a subcommittee report of the House Permanent Select Committee on Intelligence (HPSCI) notes “[p]rogram failures are often met with harsh penalties and very public rebukes from Congress which often fails to appreciate that not all failures are the same. Especially with cutting-edge research in technologies … early failures are a near certainty …. In fact, failing fast and adapting quickly is a critical part of innovation.” There is a vital difference between an innovative project that fails and a failure to innovate. The former teaches us something we did not know before, while the latter is a national security risk.

Faced with congressional hearings, inspector general reports, performance evaluation downgrades, negative reputational effects, and even personal liability, IC officers are understandably risk-averse and prefer not to introduce any new risk. That is, of course, neither realistic nor the standard the IC meets today. The IC is constantly managing a multitude of operational risks – that its officers, sources, or methods will be exposed, that it will miss (or misinterpret) indications of an attack, or that it will otherwise fail to produce the intelligence policymakers need at the right time and place. Yet in the face of such serious risks, the IC proactively and aggressively pursues its mission. It recognizes that it must find effective ways to understand, mitigate, and make decisions around risk, and therefore it takes action to make sure potential ramifications are clear, appropriate, and accepted before any failure occurs. In short, the IC has long known that its operations cannot be paralyzed by a zero-risk tolerance that is neither desirable nor attainable. This recognition must also be applied to the ways in which the IC acquires, develops, and uses new technology.

This is particularly important in the context of AI. While AI has made amazing progress in recent years, the underlying technology, the algorithms and their application, are still evolving and the resulting capabilities, by design, will continue to learn and adapt. AI holds enormous promise to transform a variety of IC missions and tasks, but how and when these changes may occur is difficult to forecast and AI’s constant innovation will introduce uncertainty and mistakes. There will be unexpected breakthroughs, as well as failures in areas that initially seemed promising.

The IC must rethink its willingness to take risks in a field where change and failure is embraced as part of the key to future success. The IC must experiment and iterate its progress over time and shift from a culture that punishes even reasonable risk to one that embraces, mitigates, and owns it. This can only be done with a systematic, repeatable, and consistent approach to making risk-conscious decisions.

Today there is no cross-IC mechanism for thinking about risk, let alone for taking it. When considering new activities or approaches, each IC element manages risk through its own lens and mechanisms, if at all. Several individual IC elements have created internal risk assessment frameworks to help officers understand the risks of both action and inaction, and to navigate the decisions they are empowered to make depending upon the circumstances. These frameworks increase confidence that if an activity goes wrong, supervisors all the way up the chain will provide backing as long as the risk was reasonable, well-considered and understood, and the right leaders approved it. And while risk assessments are often not precise instruments of measurement – they reflect the quality of the data, the varied expertise of those conducting the assessments, and the subjective interpretation of the results – regularized and systematic risk assessments are nevertheless a key part of effective risk management and facilitate decision-making at all levels.


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Creating these individual frameworks is commendable and leading-edge for government agencies, but more must be done holistically across the IC. Irregular and inconsistent risk assessments among IC elements will not provide the comfort and certainty needed to drive an IC-wide cultural shift to taking risk. At the same time, the unique nature of the IC, comprised of 18 different elements, each with similar and overlapping, but not identical, missions, roles, authorities, threats and vulnerabilities, does not lend itself to a one-size-fits-all approach.

For this reason, the IC needs a flexible but common strategic framework for considering risk that can apply across the community, with each element having the ability to tailor that framework to its own mission space. Such an approach is not unlike how the community is managed in many areas today – with overarching IC-wide policy that is locally interpreted and implemented to fit the specific needs of each IC element. When it comes to risk, creating an umbrella IC-wide framework will significantly improve the workforce’s ability to understand acceptable risks and tradeoffs, produce comprehensible and comparable risk determinations across the IC, and provide policymakers the ability to anticipate and mitigate failure and unintended escalation.

Critical Elements of a Risk Framework

A common IC AI risk framework should inform and help prioritize decisions from acquisition or development, to deployment, to performance in a consistent way across the IC. To start, the IC should create common AI risk management principles, like its existing principles of transparency and AI ethics, that include clear and consistent definitions, thresholds, and standards. These principles should drive a repeatable risk assessment process that each IC element can tailor to its individual needs, and should promote policy, governance, and technological approaches that are aligned to risk management.

The successful implementation of this risk framework requires a multi-disciplinary approach involving leaders from across the organization, experts from all relevant functional areas, and managers who can ensure vigilance in implementation. A whole-of-activity methodology that includes technologists, collectors, analysts, innovators, security officers, acquisition officers, lawyers and more, is critical to ensuring a full 360-degree understanding of the opportunities, issues, risks, and potential consequences associated with a particular action, and to enabling the best-informed decision.

Given the many players involved, each IC element must strengthen internal processes to manage the potential disconnects that can lead to unintended risks and to create a culture that instills in every officer a responsibility to proactively consider risk at each stage of the activity. Internal governance should include an interdisciplinary Risk Management Council (RMC) made up of senior leaders from across the organization. The RMC should establish clear and consistent thresholds for when a risk assessment is required, recommended, or not needed given that resource constraints likely will not allow all of the broad and diverse AI activities within organizations to be assessed. These thresholds should be consistent with the IC risk management principles so that as IC elements work together on projects across the community, officers have similar understandings and expectations.

The risk framework itself should provide a common taxonomy and process to:

  • Understand and identify potential failures, including the source, timeline, and range of effects.
  • Analyze failures and risks by identifying internal vulnerabilities or predisposing conditions that could increase the likelihood of adverse impact.
  • Evaluate the likelihood of failure, taking into consideration risks and vulnerabilities.
  • Assess the severity of the potential impact, to include potential harm to organizational operations, assets, individuals, other organizations, or the nation.
  • Consider whether the ultimate risk may be sufficiently mitigated or whether it should be transferred, avoided, or accepted.

AI-related risks may include, among other things, technology failure, biased data, adversarial attacks, supply chain compromises, human error, cost overruns, legal compliance challenges, or oversight issues.

An initial risk level is determined by considering the likelihood of a failure against the severity of the potential impact. For example, is there is a low, moderate, or high likelihood of supply chain compromise? Would such a compromise affect only one discrete system or are there system-wide implications? These calculations will result in an initial risk level. Then potential mitigation measures, such as additional policies, training, or security measures, are applied to lower the initial risk level to an adjusted risk level. For example, physically or logically segmenting an organization’s systems so that a compromise only touches one system would significantly decrease the risk level associated with that particular technology. The higher the likelihood of supply chain compromise, the lower the severity of its impact must be to offset the risk, and vice versa. Organizations should apply the Swiss Cheese Model of more than one preventative or mitigative action for a more effective layered defense. Organizations then must consider the adjusted risk level in relation to their tolerance for risk; how much risk (and potential consequence) is acceptable in pursuit of value? This requires defining the IC’s risk tolerance levels, within which IC elements may again define their own levels based upon their unique missions.

Understanding and considering the risk of action is an important step forward for the IC, but it is not the last step. Sometimes overlooked in risk assessment practices is the consideration of the risk of inaction. To fully evaluate potential options, decision-makers must consider whether the overall risk of doing something is outweighed by the risks of not doing it. If the IC does not pursue particular AI capabilities, what is the opportunity cost of that inaction? Any final determination about whether to take action must consider whether declining to act would cause greater risk of significant harm. While the answer will not always be yes, in the case of AI and emerging technology, it is a very realistic possibility.

And, finally, a risk framework only works if people know about it. Broad communication – about the existence of the framework, how to apply it, and expectations for doing so – is vital. We cannot hold people accountable for appropriately managing risk if we do not clearly and consistently communicate and help people use the structure and mechanisms for doing so.

Buy-in To Enhance Confidence

An IC-wide AI risk framework will help IC officers understand risks and determine when and how to take advantage of innovative emerging technologies like AI, increasing comfort with uncertainty and risk-taking in the pursuit of new capabilities. Such a risk framework will have even greater impact if it is accepted – explicitly or implicitly – by the IC’s congressional overseers. The final article in this series will delve more deeply into needed changes to further improve the crucial relationship between the IC and its congressional overseers. It will also provide a link to a full report that provides more detail on each aspect of the series, including a draft IC AI Risk Framework.

Although Congress is not formally bound by such a framework, given the significant accountability measures that often flow from these overseers, a meeting of the minds between the IC and its congressional overseers is critical. Indeed, these overseers should have awareness of and an informal ability to provide feedback into the framework as it is being developed. This level of transparency and partnership would lead to at least two important benefits: first, increased confidence in the framework by all; and second, better insight into IC decision-making for IC overseers.

Ultimately, such a mutual understanding would encourage exactly what the IC needs to truly take advantage of next-generation technology like AI: a culture of experimentation, innovation, and creativity that sees reasonable risk and failure as necessary steps to game-changing outcomes.

Read also AI and the IC: The Tangled Web of Budget and Acquisition

Read also Artificial Intelligence in the IC: Culture is Critical

Read also AI and the IC: The Challenges Ahead

Read more expert-driven national security insights, perspective and analysis in The Cipher Brief

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Austria will introduce a full lockdown that could last for three weeks on Monday in an attempt to tackle a new wave of Covid-19 infections. The government has also ordered the entire population to get vaccinated from February 1.

On Friday, conservative Chancellor Alexander Schallenberg told a news conference that a complete lockdown of the nation would begin on Monday and last for an initial 10 days.

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French President Emmanuel Macron (FILE PHOTO) © REUTERS/Sarah Meyssonnier
Macron discloses whether lockdown for unvaccinated will be necessary in France

He stated that the restrictions could be extended if infection rates did not start to fall, but he insisted the lockdown would not exceed 20 days.

The measures concern the entire Austrian population. The government has already imposed a partial lockdown on the unvaccinated in an effort to reduce hospitalization rates amid a surge in Covid-19 cases.

When the full lockdown ends, restrictions will remain in place for the unvaccinated.

Schallenberg’s announcement came after a meeting of nine state governors, two of whom had already vowed to introduce full lockdowns in their regions on Monday, in the western province of Tyrol.

The chancellor also announced that vaccinations would be mandatory from February 1. “We haven’t been able to convince enough people to vaccinate. For too long, I and others have assumed that you can convince people to get vaccinated,” he added, giving his rationale for the mandate.

Schallenberg said he lamented the political forces, radical opposition, and fake news fighting against vaccination.

Austria has one of the lowest vaccination rates in western Europe, with only 65% inoculated against the deadly virus according to data from Johns Hopkins university.

Infection rates are almost among the highest on the continent. The seven-day incidence rate stands at 971.5 per 100,000 people.

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People are weird. They cook and eat the strangest things. This time it’s an octopus stuffed inside a turkey, sitting on top of crab legs, and (optionally) garnished with bacon strips. This monstrous culinary invention was inspired by H.P. Lovecraft’s Cthulhu mythos, and honestly… it looks like a crime against food.

Cthulhu turkey.

Cthulhu turkey.

Cthulhu turkey.

Cthulhu turkey.

Cthulhu turkey.

Cthulhu turkey.

Cthulhu turkey.

Cthulhu turkey.

Cthulhu turkey.

Cthulhu turkey.

Cthulhu turkey.

Cthulhu turkey.

Cthulhu turkey.

Cthulhu turkey.

Cthulhu turkey.

Cthulhu turkey.

Cthulhu turkey.

Cthulhu turkey.

Cthulhu turkey.

Cthulhu turkey.

Cthulhu turkey.

If this gallery wasn’t disgusting enough for you, you should also check out pre-cooked canned chicken that we’ve previously featured on this fun and useful site. We know you’ll love it!

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As infections are rising again, scientists all around the world are rushing to fight the danger, offering a choice of new treatments and unusual variants of vaccines.

Levels of contagion are setting new records, hospitals are overwhelmed, governments are starting to introduce lockdowns, and not only for unvaccinated people ​​– the picture of the fight against Covid-19 looks quite disappointing. However, there’s still a place for good news: Research teams report positive results while trialling new medicines and vaccine types.

Nasal vaccines 

Vaccination will remain one of the most effective tools against Covid-19. As Professor David Dockrell, from the Center for Inflammation Research of the University of Edinburgh, told RT, “vaccines will continue to be a central part of how we control the virus.”

“If we can dampen down the number of infections, and the severity of infections, and also the extent to which the virus can replicate in people when they become infected, then we are slowing down the ability of the virus to change and to mutate,” he explains. 

So I think the vaccines still will be a very important part of the preventive strategy. It’s vital that they are available to all the world’s population, irrespective of where people live, and the wealth of the country in which they live. 

However, vaccination doesn’t always mean you have to get an injection. For instance, several intranasal Covid-19 vaccines are currently being developed. As the virus gets into the body through the nose, a nasal spray or drops are aimed to produce mucosal immune response and prevent it from getting into the lungs.

In India, a vaccine of this type is already completing Phase 2 of clinical trials. In Russia, a nasal vaccine is undergoing a clinical trial on volunteers. In Thailand, a home-developed product is expected to be trialed on humans next spring. In the US, Universities of Houston and Stanford recently reported good results of their experiments carried out on mice.

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A security guard checks vaccination certificates outside a business in Athens, Greece, November 6, 2021.
Another EU state to ban unvaccinated from indoor spaces

Intranasal vaccines can have several potential benefits compared to inoculation. 

“They would be easier to use, because they can be self-administered. They wouldn’t need a nurse or clinical settings,” Swedish professor emeritus of epidemiology Marcello Ferrada de Noli explained to RT. As a result, he says, there’s hope that fewer people will be reluctant to be immunized. Not so many of us find it pleasant to get a jab ​​– and after all, there are those who are just afraid of needles. Also, it would be much easier to vaccinate children with nasal substances. 

However, what concerns Prof. de Noli the most is the duration of the effect of a vaccine of this type. Still, scientists can’t say for sure whether a nasal substance may completely replace a shot. According to Alexander Gintsburg, the head of Moscow’s Gamaleya Center biomedical research institute, which created the Sputnik V vaccine, the nasal version they are working on would serve for an additional protection against the virus, but would not replace the injections.

Chew the virus away? 

A nasal vaccine is not the only one being developed. In summer, it was revealed that Russian Defense Ministry scientists were creating a ‘chewing gum’ vaccine, also targeting the mucosal immune response. Meanwhile, a UK firm announced this month that it would conduct a human trial of a skin patch that uses T-cells to confront the virus. Developers hope it would offer longer-lasting immunity than the existing vaccines. Work on a similar project is being done in the University of Queensland, Australia.

While it all looks so promising, Prof. de Noli warns that it would still take a lot of time until these products become available to the public. “I think that discoveries in this field are a very good thing. But if we say ‘We discovered a new type of vaccine’, people will say ‘Aha, so I’m going to wait’. But we need to vaccinate people now,” he points out.

Improving Covid treatment

Vaccines are not a silver bullet, unfortunately, given the not-so-high level of global immunization and the constantly emerging new strains of the virus. “People might get infected despite having had a vaccine, but I still think the vaccine strategy is going to be central to how we manage this kind of virus going forward,” Prof. Dockrell says. “But we will have other strategies that will be very important. We will have other elements. When we put them all together, it gives us the best opportunity that people can live with coronaviruses, and hopefully, the mortality can be limited to much lower extense than what we’ve sadly seen in the last eighteen months.”

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© Don Emmert/AFP
Pfizer widens access to its anti-Covid pill

Monoclonal antibodies will be central to the ongoing vaccine strategy, Prof. Dockrell explains. These are the antibodies similar to those the body uses to fight the virus. They are produced in labs and given via infusion or injection to boost the patient’s response against certain diseases. Monoclonal antibody treatment is used for people under a high risk of developing severe infection (including older patients 65+ years old or those with chronic medical conditions). It’s already being used in the US, following last year’s FDA approval. Earlier in November, the European Medicines agency recommended authorizing two monoclonal antibody medicines.

In October, UK’s AstraZeneca reported positive results of a Phase 3 study of its antibody combination, which, according to developers, is highly effective in both prevention and treatment of coronavirus.

Researchers are also working on a possibility to save Covid-infected patients from the so-called ‘cytokine storm’ – a situation when the immune system reacts so intensely that kills not only the virus, but the whole organism itself. A drug to ‘calm the storm’ was registered in Russia this year, and it’s already being used on patients.

Another way to fight Covid-19 is to use antiviral drugs. When the pandemic started, medics had to use something already existing (like anti-influenza Favipiravir) or something being authorized for emergency use (like remdesivir). Now, more than a year on, the work to create a special drug to specifically cure Covid-19 is giving its results. This month, Russia registered its first injectable anti-Covid medicine. A bit earlier, the UK became the first country to approve an antiviral pill produced by the US-based companies Merck and Ridgeback Biotherapeutics. Another American firm, Pfizer, got positive results from trials of its drug of the same kind. Both firms hope that with a drug in the form of a pill it would be easier to treat people at home.

Appreciating all the efforts on the field of developing anti-Covid treatment, Prof. de Noli points out that still, the key issue now is to reduce the spreading of the virus. “The new medicines are developed for people who already got the disease,” he says.

But we need to prevent people from getting the infection, not let them get infected because we have some new medicine that can cure them.

The same idea is echoed by scientists all over the world quoted in plenty of articles dedicated to the medical gains: it’s great to have the treatment, but none of the drugs may substitute vaccination, as first and foremost, humanity has to adopt preventive measures and stop the pandemic.

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