Scientists in Sweden claim that a single protein in the blood could predict the onset of Type 2 diabetes nearly 20 years in advance. The breakthrough potentially affects hundreds of millions of people worldwide.

Diabetes is the world’s ninth-leading cause of death, and affects nearly half a billion people worldwide, according to the World Health Organisation (WHO). The vast majority of diabetes patients suffer from Type 2 diabetes, a condition that can lead to blindness, kidney failure, heart attacks, strokes, and lower limb amputation. Cases of diabetes quadrupled worldwide between 1980 and 2014, with unhealthy diets and lack of exercise blamed for the rise.

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However, researchers at Lund University in Malmo, Sweden claim that elevated levels of a certain protein – follistatin – in the blood can predict the onset of Type 2 diabetes regardless of a person’s age, weight, diet or activity level. In a study published last week, the scientists wrote that high levels of follistatin can predict the condition up to 19 years before symptoms appear.

To discover the link between follistatin and diabetes, the researchers tracked 5,300 people from Sweden, Italy, and the UK for between four and 19 years. Follistatin helps break down body fat, while simultaneously leading to an increase in fat in the liver. This buildup can cause fatty liver disease and Type 2 diabetes.

“This study shows that follistatin has the potential to become an important biomarker to predict future Type 2 diabetes, and it also brings us one step closer to the understanding of the mechanisms behind the disease,” Dr. Yang De Marinis, associate professor at Lund University and lead author of the study, told a university newsletter. De Marinis added that the next step for her team would be to help develop an AI-based diagnostic tool that could analyze a patient’s blood sample and use their follistatin levels – and other biomarkers – to calculate their “risk score” for Type 2 diabetes.

As follistatin levels rise in response to food intake and activity levels, the same advice for prevention of diabetes still applies. “Balanced meals, eat[ing] healthy and regular exercise are important to decrease the risk of developing Type 2 diabetes,” De Marinis told StudyFinds.

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The EU’s drug regulator has backed the emergency use of Merck’s pill for the treatment for clinically vulnerable Covid-19 patients as cases surge across the continent.

On Friday, the European Medicines Agency (EMA) “issued advice” backing the emergency use of the drug developed by Merck in collaboration with Ridgeback Biotherapeutics, although it has not yet been authorized by national authorities.

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In a statement, the drug regulator said the medicine called Lagevrio – also known as molnupiravir or MK 4482 – “can be used to treat adults with Covid-19 who do not require supplemental oxygen and who are at increased risk of developing severe Covid-19.

It said the treatment should be administered as soon as possible after Covid-19 is diagnosed and within five days of the start of symptoms. The medicine should be taken twice a day for a period of five days.

The EMA listed the potential side effects of the capsules, including mild or moderate diarrhea, nausea, dizziness and headache. The treatment is not recommended for pregnant women.

The watchdog announced earlier on Friday that it had begun reviewing Pfizer’s medicine Paxlovid for Covid-19 with the same goal “to support national authorities” who may decide on its early use prior to marketing authorization in light of rising cases and deaths in Europe.

On Friday, Austria announced it would enter a new nationwide lockdown from Monday and make vaccination mandatory, while Germany’s health authorities claimed the country had turned into “one big outbreak.”

Both Pfizer and Merck have requested approval for their coronavirus medicines from the US Food and Drug Administration, but it is unclear when it might be granted.

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Japan’s fifth wave of Covid-19 has virtually disappeared so dramatically that some scientists are puzzled as to why it happened. One team suggests the highly infectious Delta strain mutated into extinction on the island nation.

In mid-August, Japan experienced a peak in Covid-19 infections, recording over 23,000 new cases per day. Now the metric is just around 170, with deaths attributed to the disease mostly remaining in single digits this month.

The decline has been attributed by many to high vaccination rates, public acceptance of masks, and other factors, but some researchers say the drop was uniquely significant, compared to other nations with similar conditions.

Ituro Inoue, a geneticist at the National Institute of Genetics, believes that Japan had the good fortune of witnessing the Delta strain mostly rooting out other variants of the SARS-CoV-2 virus before then eradicating itself. He explained his team’s theory to the Japan Times newspaper this week.

For some time now, Inoue and his fellow scientists were researching mutations of SARS-CoV-2 and how they are affected by the protein nsp14, which is crucial for the reproduction of the virus.

RNA viruses, like the one causing Covid-19, tend to have a very high mutation rate, which helps them quickly adapt to changes in the environment. However, this opens the door for a so-called “error catastrophe,” when bad mutations pile up and finally cause the full extinction of a strain. The protein nsp14 appears to offer a form of error proofreading that helps the virus genome to stay below the threshold of the “error catastrophe.”

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In the case of Japan’s fifth wave of Covid-19, the Delta variant’s nsp14 failed at this job, Inoue believes, based on the genetic study of specimens collected from June to October. Contrary to his team’s expectations, there was a lack of genetic diversity, while many samples had many genetic changes in the site called A394V, which is linked to the error-fixing protein.

“We were literally shocked to see the findings,” the researcher told the Japan Times. “The Delta variant in Japan was highly transmissible and [was] keeping other variants out. But as the mutations piled up, we believe it eventually became a faulty virus and it was unable to make copies of itself.”

The theory could be relevant to the previous SARS strain, which was identified in 2003, explaining why it didn’t cause a pandemic. But that would be hard to confirm, since the outbreak ended relatively quickly and didn’t result in the massive collection of genetic data necessary to test the hypothesis.

It’s not clear why Japan had this lucky turn of events, but nothing comparable happened in other East Asian countries like South Korea, where populations are genetically close to that of Japan. Virus mutations similar to those flagged by the scientists have been discovered in at least 24 countries, Inoue said. He and his team plan to publish a paper detailing their findings by the end of November.

Even if the natural extinction theory is confirmed, it is at best a temporary reprieve for the Japanese people. New, more successful strains are likely to eventually find their way into the country, though quarantine measures and immigration control could delay the emergence of new variants in Japan, Inoue believes.

Meanwhile, Tokyo is bracing for a new wave of Covid-19 this winter and is preparing to live with the virus. The government reportedly plans to ease travel restrictions by increasing the number of people it allows to enter the country per day from 3,500 to 5,000.

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Chris Inglis’ new White House office has a startup feel to it. There are desks, a few chairs, a coffee maker and a poster hanging on the wall.  But as the head of the newly established Office of the National Cyber Director, Inglis has to make due with what he has while still advising President Joe Biden on the smartest ways for the US to prevent and respond to cyberattacks.

Inglis has already had numerous conversations with the president, who has made clear that the government has a role to play in the defense of the private sector and in assisting the private sector in defending critical infrastructure.  And the president knows, says Inglis, that means the government needs to get its own cyber house in order. 

But like any real startup, Inglis’ resources are scarce.  More than three months after being confirmed by the Senate, he still doesn’t have the full staff he needs to take on his timely and critical mission.  That’s because the funding for his office – some $21 million, part of the $1 trillion infrastructure bill making its way through Congress – is still stuck in the political spin cycle.  Why does it matter?

“The threat is greater than I can ever remember,” Inglis told me during last month’s AFCEA and INSA Intelligence & National Security Summit in National Harbor, Maryland. “The audacity, the brazenness, the thresholds that have been crossed at every turn; we’re in a difficult place.”

While he’s waiting for Congress to act, he says he’s spending about fifty percent of his time defining his role, being careful not to duplicate the work already being done by other agencies and departments, while spending another fifty percent building relationships that will be important later.  Eventually, he’s expected to have a staff of some 75 people who will be expected to work hand in glove with CISA, the National Security Council’s cyber staff, the OMB and others.  The remaining fifty percent of his time, Inglis jokes, is spent figuring out how to attract the country’s best talent.   

“People are starting to flow into the organization. I’m confident that we’re coming up to a breakout moment, not for the National Cyber Director, but the contribution that we can and should make. I’m sobered by the nature of the challenge, I’m optimistic we can make a difference.”

Optimistic he is.  And he’s not even complaining about being given a critical task for US national security and then having to wait for politics to play out before being able to act on it.

“It has been a semi-silver lining in that we would not have had time to think about how we want to apply the resources coming our way.”

While Inglis has been waiting, he and his small team have had time to think about the four things they’d like to focus on right away. 

First, is streamlining the roles and responsibilities in government of who handles what when it comes to protecting the public and private sectors from cyberattacks.  He also spoke during his confirmation hearing about the importance of allocation of resources and while the Office of the National Cyber Director doesn’t have the authority to move money, it does have what Inglis calls the responsibility to account for cyber money.

“One of the most critical gaps in cyber is that the physical digital infrastructure is not built to a common standard. The executive order related to this requires that within a certain amount of time we have to install basic procedures like multifactor authentication and encryption of stored material. That is a challenge and a potential vulnerability for us. We need to make sure that we make these investments necessary to buy down the lack of investment for years.

The second gap is in talent related to number of people required to occupy these jobs. It’s not simply the folks with IT or cyber in their name, but general cyber awareness. There is some expenditure of resources of time, attention, and money to get awareness right on the part of the truly accountable parties like agency and department heads. We have to make sure they don’t see cyber as a cost center, but an enabler on the part of all the users as they understand what their roles are and what the accountability is.

He admits there is still a level of education needed within government to get there.

That is usually the case in both the government and the private sector,” he said.  “We need to think this way about cyber and invest in cyber so that we can enable the mission, not hold it back. I think that education is the most important and effective way to handle this. Then, it is to make sure that the accountability is aligned and harmonized. We tend to take risk in one place and expect someone in another place to be the mitigator of a risk they don’t understand was taken in the first place. We need to operate in a collaborative fashion and get away from divisions of effort which are an agreement not to collaborate and allow adversaries to pick us off one at a time.”

Inglis says that unity of effort must start at home.  “The executive order issued in May has begun to lay out common expectations about the hardware, software, and practices that we need to begin in those spaces,” he said.  “Externally, if we have sector risk management agencies who engage the private sector for the purposes of supporting and engaging the critical components of that infrastructure, we need to make sure you don’t need a Ph.D. in government to know who to deal with and what you’re going to get from them.”

He is arguing for the government to also put ‘valuable material’ on the table.  “That could be our convening power,” said Inglis. “We could perhaps address and reduce liability or give companies a clue as to what might be around the corner because the government has access to exquisite intelligence. If that setup is possible, we also need a venue where collaboration takes place. Information doesn’t collaborate, people do.”

Inglis likes to point to the example of CISA and the Joint Cyber Collaborative.  “They put people from the private sector and the public sector side by side to co-discover threats that hold us at common risk. That project sets up the possibility of implicit collaboration in what we then do with that common operational picture. The government could take ideas that private sector companies turn into proprietary systems and enrich and classify them to deal with it in their system.”

Using what he calls “all the tools in the toolkit,” Inglis also notes the importance of international relationships, which fits nicely into the White House’s International Summit on Ransomware last week in Washington, which zeroed in on tighter cryptocurrency standards, among other things. “Beyond the Five Eyes, what do other like-minded nations think about what is expected behavior in this? What are governmental actions that are appropriate,” he asked.  

Inglis has been an active participant in the president’s recent actions in cyber.  He took part in a White House meeting with tech leaders in August that was hosted by President Biden, who Inglis says, spent the first hour sharing his vision about how the country should focus on collaborative integration.  “The companies represented weren’t only companies like Microsoft and Apple, but people who operate in the critical infrastructure space,” said Inglis.  “The people component, educators, were represented reflecting the president’s view that cyberspace is not just technology, it is also the people component. They are a major link in the chain, and we need to get the roles and responsibilities right.”

While he’s waiting for the funding he needs to get his office fully staffed, Inglis said he’s also putting thought into reconciling resources with aspirations.  Managing expectations is going to be important.  Frustration has been growing for years over what some see as a lack of government response to some of the largest hacks in history.  The phrase ‘time and place of our choosing’ as a definition of response has grown old and some Americans are weary of a government that isn’t responding in a more public way to the beating it sees the US taking in cyberspace.

So, I asked Inglis whether there should be red lines in cyber.

“Red lines are both good and bad,” he answered.  “They are clear and crisp, and everybody knows what they are. The downside is that because of that, an adversary knows exactly how far they can go. It means that you set up a somewhat permissive environment. Red lines also don’t have context; sometimes there is a reason that a defender would make the ransomware payment. As a matter of policy, the U.S. government does not pay ransomware, but I imagine there will be a situation at some point where a hospital is against the Russian state and actual life and safety is at risk. If there is no other way to get the material back, in order to get back in the business of saving lives, they would want to rethink if a red line is a red line in that particular situation. I think the right thing to do here is not to establish hard thresholds of things with scripted responses, but outline what we are prepared to defend and what principles we will exercise in defense of those things. We commit to defending the private sector when it is held at risk by a nation state in cyberspace as much as in the kinetic space and make that clear to adversaries. I think that would be more helpful in changing decision calculus and creating a useful ambiguity about when and where we will come in.”

Inglis said he’s also thinking a lot about present and future resilience.  It’s a worthwhile focus, given that the White House estimates that nearly half a million public and private sector cybersecurity jobs are currently unfilled. 

“That is a massive problem,” said Inglis. “However, the more insidious problem is that the 320 million people in the United States who use the internet who have no idea how to properly take their place on the front lines of this issue. There is an awareness issue that requires us not to make Python programmers out of them but to make sure they understand the nature of this space.”

Everyone has heard the old saying that time is money, but in Inglis’ case, time is security so I asked him point blank whether he thought government was moving has quickly as it should on the cyber problem.

“Government is moving at speed; the question is if it is at the necessary speed. I don’t think anyone is moving at the necessary speed. Some are moving at light speed, but at the end of the day, we need an integrated, collaborative approach. While we won’t have unity of command, I think there needs to be a universally felt sense of urgency so that we will all get our heads in the game.”

Congress, are you listening?  Oh, and by the way, that poster in Inglis’ office? It reads, ‘Hours Since the Last Surprise.”

As a startup with maybe too few resources at the start and who often didn’t understand how all the wickets are run, we have our occasional surprise,” said Inglis.  “When we encounter those surprises and go to someone with the deep and sharp expertise to help us navigate that, we get what we need. However, we are not a full functioning, full featured, fully capable organization yet. We’re trying to build somebody else’s airplane while we’re free falling from our own. We have a parachute, and we can land safely, but it is a bit of a challenge at times.”

Find out more about why experts like former NSA Director General Keith Alexander (Ret.), Mandiant CEO Kevin Mandia and others have joined The Cyber Initiatives Group, powered by The Cipher Brief

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The city council in Austria’s second-largest city, Graz, has elected a new mayor. Communist Party member Elke Kahr has become the first Communist leader of a major city in the country.

The 60-year-old politician, who has been working in the municipal government for more than 15 years and previously served as vice mayor of Graz, was elected as the new city leader on Wednesday. A member of the Austrian Communist Party (KPÖ, Kommunistische Partei Österreichs) for almost 30 years, she won the election with 28 of 46 votes. Kahr succeeded the previous long-standing mayor Siegfried Nagl of the center-right, liberal-conservative People’s Party.

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Who would have thought that the daughter of a locksmith, a Communist, would become mayor,” she said in her first speech following the vote.

Having acknowledged a number of issues to deal with in the city, especially during the Covid-19 pandemic, the new mayor highlighted a housing policy, pledging to put a stop to profit-driven construction in Ganz.

The Communists have also already formed a coalition with the Greens and the Social Democratic Party (SPÖ), and another precedent in European city governance was made – two women serving as mayor and deputy. Green leader Judith Schwentner was chosen as Graz’s vice mayor, with the new governing coalition saying they would support not only social, but also environmental changes, aiming to improve living standards especially for low-income groups. Providing a bicycle for every child in the city from the municipality is in their program.

However, not everyone in the local government is happy with the new Communist rule. A member of the right-wing Freedom Party of Austria (FPÖ), Alexis Pascuttini, described the choice as “unpleasant,” having accused the Graz Communists of empty catchphrases in their program and refusing to participate in what he described as “left-wing nonsense.” Kahr herself has been exposed to strong pressure to justify her party, being repeatedly asked about her position on “the crimes of communist parties around the world since 1917,” according to Austrian media.

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As information emerges about Islamic State of Khorasan, or ISIS-K – the terrorist group that claimed responsibility for last week’s suicide attack that killed 13 US service members and more than 160 Afghans – there is an increased effort to predict how Afghanistan, under Taliban rule, may emerge once again as a breeding ground for terrorist groups.

A United Nations report released in June estimates that thousands of fighters from the region had already poured into Afghanistan.  Many of them are believed to be affiliated with either the Taliban – still seen as a terrorist organization – or al Qaeda or ISIS-K.

The New York Times reports that ISIS-K was created six years ago by members of the Pakistani branch of the Taliban.  There is a range of thought among experts as to what their ability to successfully carry out a terrorist attack in a Taliban-ruled area means for the terrorist threat moving forward. 

The Cipher Brief spoke with respected terrorism experts Bruce Hoffman, Mitch Silber and Colin Clarke to get their thoughts on the current risk of terrorist attacks against Americans both home and abroad. 

Bruce Hoffman, Terrorism Expert and Professor, Georgetown University

Cipher Brief Expert Bruce Hoffman is a professor at Georgetown University and served as a commissioner on the Independent Commission to Review the FBI’s Post-9/11 Response to Terrorism and Radicalization.  He is also a Scholar-in-Residence for Counterterrorism at CIA.

Mitch Silber, Former Director of Analysis, NYPD

Cipher Brief Expert Mitch Silber served as Director of Intelligence Analysis at the New York City Police Department and served as principal advisor to the Deputy Commissioner of Intelligence on counterterrorism policy and analysis. He is now executive director of the Community Security Initiative.

Colin Clarke, Director of Policy and Research, The Soufan Group

Colin P. Clarke, Ph.D., is the Director of Policy and Research at The Soufan Group. Clarke’s research focuses on domestic and transnational terrorism, international security, and geopolitics. He is also a senior research fellow at The Soufan Center.  

The Cipher Brief: If the United Nations Report issued in June is accurate, and there are thousands of fighters from the region who have poured into Afghanistan – many associated with known terrorist groups – is there any way that the administration can say ‘mission accomplished’ in terms of degrading terrorism’s presence in Afghanistan? 

Hoffman: No. As those numbers from the report released by the United Nations Support and Sanctions Monitoring Team highlight, Afghanistan is again becoming a jihadi magnet and will likely continue to be so into the future. The suicide bomb attacks outside the gates of Kabul International Airport last Thursday underscore the multiplicity of terrorist groups already present in that country.

In addition to ISIS-K, there is the Haqqani Network, al Qaeda and, of course, the Taliban. Terrorism thrives in conditions of chaos and instability which the terrorists hope to spread to other countries and eventually across regions.

Much as Salafi-Jihadi terrorists migrated from existing battlefields in South Asia back to the Middle East, North Africa, and the Caucasus in the 1990s; spread to East and West Africa in the early 2000s; blossomed during the Arab Spring to wage civil wars in Syria, Libya, and the Sahel, in the early twenty-teens; the same phenomenon is unfolding in Afghanistan.

Silber:  Frankly, I don’t think any of the four administrations can make the claim that the policy goal of making Afghanistan inhospitable to serve as a safe haven for Al Qaeda or other similarly oriented jihadist groups has been accomplished.  Certainly, at a number of times during the last twenty years, the threat that jihadist groups, most importantly — Al Qaeda — has presented, in terms of their ability to project a threat to the United States has been diminished, the degradation of the threat was only temporary.

The Cipher Brief: How confident are you that Al Qaeda and ISIS are unable to plan and execute attacks against the U.S. domestically? 

Hoffman:  The credulous Doha negotiations with the Taliban that led to the withdrawal of U.S. military forces from Afghanistan and subsequently to the Taliban’s blitzkrieg across Afghanistan and then to the shambolic evacuation of our diplomats and citizens, has painted a huge target on America’s back. Like sharks in the water, terrorists will smell blood. As my Council on Foreign Relations colleague, Jacob Ware, and I wrote in War on the Rocks, in May, every time terrorism has forced the U.S. to withdraw from a conflict zone where it had committed ground forces, whether in Lebanon in 1984; Somalia in 1993; and Iraq in 2011, it has led to more terrorism worldwide, not less, and thus made the U.S. less safe.

At a time when our country continues to grapple with the COVID pandemic; when climate change is pulverizing the Gulf States with Hurricane Ida and California with worsening wildfires; when the January 6th insurrection at the U.S. Capitol building continues to smolder with incidents such as the bomb threat that paralyzed the area near the Library of Congress and Cannon House Office Building earlier this month; coupled with ongoing cyberattacks and peer competition from China and Russia and concerns over Iran’s nuclear aspirations; our terrorist adversaries may well conclude that the U.S. is sufficiently preoccupied or distracted by any or all of the preceding and therefore conclude that the time to strike the homeland is opportune. It would very unlikely entail a repeat of the catastrophic September 11th 2001 attacks. But a terrorist strike along the lines of the 2019 shootings at Naval Air Station Pensacola; the 2017 suicide bombing of a concert venue in Manchester, England; the coordinated suicide attacks on London transport in 2005; the 2004 Madrid commuter train bombings; or any kind of significant lone wolf incident perpetrated in the name of some existing terrorist movement would likely re-create the widespread fear and anxiety that are terrorism’s stock-in-trade. Twice in the past three years, it should also be noted, members of al-Shabaab – perhaps al Qaeda’s least technologically proficient franchise – have been arrested both in the Philippines and in an undisclosed African country engaging in the same flight training that four of the 9/11 hijackers undertook before their fateful, history-changing coordinated attack.

Silber:  At this very moment, it is unlikely that Al Qaeda or ISIS-K have the infrastructure, resources, recruits and external planning ability to strike the United States based on statements by the IC and senior DoD officials to Congress.  However, without any, or only limited external pressure by the U.S. military as a result of the retreat from Afghanistan, these networks and capabilities can be reconstituted in the coming months and certainly groups like Al Qaeda have never given up their desire to strike the American homeland.

Clarke:  I think it is unlikely that AQ or ISIS will be able to attack the U.S. homeland.  We’ve spent the better part of the past two decades shoring up homeland defense. We’ve got CT tools now that we didn’t have twenty years ago. That said, the picture could look quite different 6, 12, 18 months from now. Both of those organizations are capable of regenerating an external operations planning capability. There is also the worry of inspired attacks.


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The Cipher Brief:  Some analysts have said that morale among terrorist or Islamic extremist groups is extremely high due to the circumstances surrounding the US pullout in Afghanistan, do you agree and if so what does that mean? 

Hoffman:  Yes. Of course. Both Sunni and Shi’a terrorist movements around the globe have applauded the Taliban’s re-conquest of Afghanistan and routing of the U.S. military. For Sunni Salafi-Jihadi terrorists, the events there this past month validate the strategy articulated by Usama bin Laden just before the 2004 U.S. presidential election, when he described the ease with which al-Qaeda had been able to “bled Russia for 10 years, until it went bankrupt and was forced to withdraw in defeat” from Afghanistan in 1989, and predicted that the same fate would eventually befall the U.S. And, Sayed Hassan Nasrallah, the Secretary-General of Hezbollah, a Shi’a terrorist organization, for instance, last week delivered a sermon where he described America’s “historic and humiliating defeat in Afghanistan as representing, “the moral downfall of America.”

Silber:  Jihadi chat rooms and online extremist networks are feeling like they have the wind behind them.  It took twenty years, but before the 20th anniversary of the attacks of 9/11 an Islamic emirate has been re-established in Afghanistan.  Suddenly, what seemed impossible has become possible and Islamist insurgencies all throughout the Middle East and South Asia can take inspiration by the determination of the Taliban in their efforts to overthrow a secular democratic government and replace it with an Islamist one.

Clarke:  I do expect morale to be high among terrorist and especially Islamic extremists given the turn of events we’ve seen in Afghanistan. We’re a week and a half out from the 20-year anniversary of 9/11, and Al Qaeda leaders are returning to Afghanistan (this is being displayed in AQ propaganda). We’ve seen al-Qaeda affiliates all over the globe congratulating the Taliban for their victory. I don’t want to overstate the case here, but I do believe that what has occurred in Afghanistan will be a serious boost for the global jihadist movement right at the same time the U.S. and its allies are shifting from counterterrorism to great power competition. There will be fewer resources and energy to deal with terrorists, right at the time we have major threats metastasizing in Afghanistan, potentially with both a reinvigorated al-Qaeda and a stubbornly resilient ISKP.

Read also Mike Leiter’s Why We’re Much Safer from Terrorism Now, Than We Were After 9/11 in The Cipher Brief 

Read also Why We Need a New National Defense Strategy (for terrorism) exclusively in The Cipher Brief 


Go beyond the headlines with expert perspectives on today’s news with The Cipher Brief’s Daily Open-Source Podcast.  Listen here or wherever you listen to podcasts.


 

The post The Risk of Terrorism at Home and Abroad appeared first on The Cipher Brief.

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Hundreds of major websites returned ‘404: not found’ errors after an apparent problem with Google Cloud. Alphabet said the problem was “partially resolved” after about ten minutes, but it will take time for everything to update.

The site Downdetector began showing a spike in reports of outages starting at 12:40pm Eastern time on Tuesday, affecting Google, Facebook, Instagram, Snapchat, Discord, Spotify, and TikTok, as well as e-commerce sites Target, Etsy, Shopify, and Home Depot, among others.

Amazon, Amazon Web Services (AWS), and Cloudflare were also affected.

Google’s Status Dashboard reported an unspecified “issue” with the Cloud service starting at 10:10 Pacific, which was causing users to encounter errors when accessing websites. 

“We believe the issue with Cloud Networking is partially resolved,” the company said by 10:17 PST, but it added that “Customers will be unable to apply changes to their load balancers until the issue is fully resolved,” and they did not have an estimate as to when that might be.

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China has accused the Philippines of breaching its territory, saying two supply ships were blocked by Beijing’s coast guard as they approached a disputed shoal. Manila protested over the run-in, citing its own claim to the area.

The two Philippines vessels “trespassed” into waters near the Nansha island chain – also known as the Spratly Islands – on November 16, Foreign Ministry spokesman Zhao Lijan told reporters on Friday, noting that they entered the area “without China’s consent.”

“Chinese coast guard vessels performed official duties in accordance with law and upheld China’s territorial sovereignty and maritime order,” Zhao said, adding that the area is now “generally tranquil” and that the two countries are in communication about the encounter.

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The comments from Beijing come just one day after Manila first publicized the incident, with the Philippines Foreign Affairs Secretary Teodoro Locsin claiming Chinese vessels fired water cannon on the two supply boats and forced them to abandon their mission near a disputed shoal in the Spratlys. He called on China to “back off” and “take heed” of Philippines claims to the region. 

While both countries regard the Ayungin shoal – alternatively referred to as the Second Thomas or Renai Jiao shoal – as their own territory, The Hague’s Permanent Court of Arbitration settled the dispute in the Philippines’ favor in 2016. However, despite that ruling, as well as the fact that Manila has maintained a presence on the shoal since 1999, Beijing has not abandoned its claims to the area.

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Hospitals in the Netherlands have begun delaying certain operations to free-up ICU beds during a record wave of Covid-19 infections, while an infectious diseases researcher has warned of an impending ‘Code Black’ in the sector.

The country set a daily national record for new Covid infections on Thursday, registering around 23,600 cases. It was the third day in a row of the figure topping 20,000.

To make more staff available for Covid wards, a number of operations, including those for cancer and heart patients, are being canceled from this week on, Dutch healthcare officials have said. Fewer than 200 beds remained available in Dutch ICUs as of Thursday, while Friday figures show almost half (47.8%) of occupied ICU beds were being used by Covid patients.

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“These are cancer patients that should actually be operated-on within six weeks of diagnosis, and that won’t be met in all cases. It’s also heart patients,” said a spokesperson for the National Coordination Center for Patient Distribution (LCPS).

Meanwhile, new calculations by an infectious disease modeller at Wageningen University & Research suggest that a so-called ‘Code Black’ in hospitals is looming. The emergency designation means that patient safety is at risk and, if declared, would mean many people with life-threatening illnesses cannot go to the ICU, while doctors have to prioritize who to treat.

According to recent estimates from the Dutch Healthcare Authority (NZa), up to 200,000 operations were not performed as a result of urgently needed Covid care since the start of the pandemic. On Thursday, the NZa revealed that almost a quarter of operating rooms across the country are not currently in use due to a combination of Covid patient pressures and rising staff absences due to illness.

It is not yet clear what impact the delayed care will have on public health. In December 2020, the Dutch National Institute for Public Health and the Environment (RIVM) calculated that an estimated 34,000 to 50,000 ‘healthy life years’ had been lost due to the first Covid-19 wave alone.

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EXPERT OPINION — More than 200 U.S. officers have been hunted around the globe and targeted by an adversary using a mysterious weapon that causes permanent brain injury. It’s time to get serious about fighting back.

The Authors:

Paul Kolbe served for 25 years in the CIA’s Directorate of Operations. He is currently Director of the Intelligence Project at Harvard Kennedy School’s Belfer Center for Science and International Affairs.

Marc Polymeropoulos worked for the CIA for 26 years. He is author of “Clarity in Crisis: Leadership Lessons from the CIA.

John Sipher worked for the CIA’s clandestine service for 28 years. He is now a nonresident senior fellow at the Atlantic Council and a co-founder of Spycraft Entertainment.

Prior to 9/11, al Qaida declared war on the United States, bombed the USS Cole, and blew up U.S. embassies in Nairobi and Dar es Salam. Despite heavy casualties, America viewed successive al Qaida terrorist attacks as somehow unique, not representative of a larger threat or state of war. We went about our business and failed to take hard action against al Qaida despite clear warning. Our failure to respond forcefully led to 9/11 and the two decades of war that followed.

Fast forward to today.  Since 2016, more than 200 U.S. officials have reportedly suffered from a mysterious series of symptoms which have caused long-lasting, debilitating injuries. Suffering from searing headaches, vertigo, vision impairment, and nausea, many victims have been formally diagnosed with traumatic brain injuries (TBI) at the Walter Reed National Military Medical Center and other leading hospitals. Family members and young children have suffered as well. Some medical tests can now confirm the markers of brain injury, similar to those suffered by victims of concussive injuries in Iraq and Afghanistan.

These injuries began with a cluster of reports from Cuba in 2016 and have become commonly referred to as Havana Syndrome. Moscow, Vienna, Belgrade, and Hanoi are among more than a dozen cities where U.S. officials reportedly have been attacked and injured. In residences, on the street, in vehicles, and even at secure U.S. facilities, U.S. officers are being hunted. Stunningly, even a close aide to CIA Director Bill Burns was reportedly attacked on a trip to India just this past August.

The CIA, after a period of confusion, delay, and even denial at times, now appears to take these threats very seriously. CIA Director Burns and Deputy Director David Cohen have publicly stated that U.S. officials are being “attacked.” They have improved health care for CIA officers who are hurt. And an agency task force is hard at work trying to obtain additional intelligence on those responsible. We credit Director Burns for his solid leadership.

The cause of these injuries? The National Academy of Sciences has pointed to Directed Energy Weapons – devices which emit microwave pulses which can inflict pain and damage tissue. The United States, Russia, China, and others have all developed Directed Energy Weapons to destroy equipment, counter drones, and control crowds. This is not science fiction.

Directed energy weapons would account for the highly directional and locational nature of these incidents. When victims can “move off the x,” the signature sounds, sensations, and pain that goes with the attacks often stop, though damage has already occurred. The amount of exposure seems to affect the degree of injury. Other technologies could be at play and are being investigated, but microwaves appear to be the most likely vector. Russia has used them before, flooding the U.S. Embassy in Moscow with microwave radiation for decades.

Regardless of form, the weapons being used in these attacks are nothing less than weapons of terror, designed to cause injury to non-combatants. Who would use such a weapon to attack U.S. intelligence officers, diplomats, and military personnel, and to what conceivable end?


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CIA Deputy Director Cohen stated at a recent intelligence summit, that the U.S. was closer to identifying the culprit, and Politico has reported that members of the Senate Intelligence Committee are increasingly convinced that Russia or another hostile adversary is behind the attack, although reportedly, no smoking gun has been found.

As former CIA operations officers with extensive experience dealing with both counterterrorism and counterintelligence issues, we have few doubts about who will be named as the culprit. For at least a decade, Russia has conducted itself as in a state of conflict with the West in general and the United States in particular. Russia has launched cyberattacks impacting critical infrastructure and supply chains, assassinated opponents with nuclear poisons and chemical weapons, gunned down people in the streets using criminal proxies, sabotaged a Czech ammunition depot, and mounted a violent coup attempt in Montenegro. It has also bombarded the U.S. embassy in Moscow with microwave radiation and used carcinogenic “spy dust” without regard to health effects. The attacks on U.S. officials would fit this pattern of behavior.

We recognize that it is important to let the intelligence community do its job and its findings must inform policy action. Congress and the administration must work together to formulate a range of possible responses and it is not too early to begin. As Senator Collins and others have stated, these attacks are “an act of war,” and as such, preparation for a future attribution call by the national security establishment is in order. So how could the U.S. respond?

Let’s start with what doesn’t work – sanctions. Sanctions feel good and satisfy an action imperative but they are feckless. Sanctions have not stopped Russia from killing dissidents, halted the Nordstream II pipeline, compelled a pull back from occupied territories, reduced support for tyrants, or hindered oil and gas production. Sanctions have simply forced Russia to develop more creative money laundering and sanction circumvention mechanisms.

So, what would work? For starters, we must understand that the Putin regime considers itself in a state of conflict with the U.S., short of war, but nonetheless deadly real. We are dealing with a state sponsor of terror which conducts operations across the globe to weaken the U.S. abroad, divide it from its allies, and sow discord at home. Our policy must be calibrated to win this conflict, without sparking a shooting war, but at risk of one.

Russia understands reciprocity and strength. When four Russian diplomats were kidnapped by extremists in Beirut in 1985, and one of them was killed, Russia reportedly responded by kidnapping and gruesomely killing a relative of the group’s leader. The surviving diplomats were released immediately. The story may be apocryphal, but it does illustrate the Russian approach. Tempting as it may be for America to retaliate tit for tat, we need not mirror Russia’s actions. Instead, we should play to our greater economic, diplomatic, and military advantages.

We offer five elements to frame a response: enlist U.S. allies, expand forward deterrence, limit the adversary’s reach, choke off money, and bring those accountable to justice.

NATO: With proof of the attacks on U.S. officials, we should activate NATO’s Article Five collective defense clause. The only other time this was enacted was after 9/11. As justification, in addition to the Havana Syndrome attacks, (which also caused Canadian casualties), we would include GRU and FSB assassination operations across Europe, deadly sabotage in the Czech Republic, a coup attempt in Montenegro, persistent cyberattacks, and a litany of other actions that can only be described as irregular warfare directed against NATO members.


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Forward Presence: A crystal clear signal that we understand the nature of Russian hybrid warfare and are responding would be to enhance our deployed military presence in Poland, the Baltic States, and in the Black Sea region. These units would pose no offensive threat to Russia but would be a clear signal that the U.S. is prepared to counter any Russian shenanigans. We should also significantly ramp up our lethal aid and training to the Ukraine, where the nature of Russian aggression is well known. Weakness in Eastern Europe is an invitation to conflict.

Travel and Presence: We should drastically limit Russian business and tourist travel which is being used as cover for FSB and GRU operations. We would reduce Russian diplomatic presence in each capital to the bare minimum – handfuls not hundreds. American and European counterintelligence experts believe there are more Russian intelligence officers operating from embassies than during the Cold War. Limiting the size of Russia’s espionage infrastructure will complicate the planning and execution of all of its intelligence operations.

Finance: A key tool in counterterrorism operations is the ability to target sources of finance which constitute material support to terrorism. In this case, we would apply that principle to the Russian government, state enterprises, and individuals who provide cover, tools, and sources of funding to Russia’s campaign to undermine the West with violence, terror, and media manipulation. Russia’s dirty money has been used to undermine the west and poison our politics. We should limit the easy access of shady money to western banks.

Criminal Cases: We need bring war crime cases to the International Court of Justice (ICJ) in the Hague. Following a decade of conflict in the Balkans, the ICJ brought to justice 161 indicted Serbian, Croatian, and Bosnian war criminals. This was an astounding success – a manhunt which included American and European law enforcement and intelligence services. Just as in Nuremberg after World War II, these actions to hold war criminals accountable drew a line in the sand.

This is a start.  Successive Democratic and Republican administrations have pursued Russia policies which represent the triumph of hope over experience. We have treated the symptoms of malign Russian actions rather than the underlying pathology. It is now time to finally acknowledge that we are in a long-term hybrid conflict and forget the fantasy of changing Putin’s behavior. Only a new regime in the Kremlin would hold the hope of bringing about a change in actions. Eventually, the Putin regime will wither or collapse, but until it does, we and our allies must do a better job of defending ourselves.

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