Scientists have used artificial intelligence to “predict” formulas for new designer drugs, with the stated goal of helping to improve their regulation. The AI generated formulas for nearly nine million potential new drugs.
Researchers with the University of British Columbia (UBC) used a deep neural net for the job, teaching it to make up chemical structures of potential new drugs. According to their study, released this week, the computer intelligence fared better at the task than the scientists had expected.
The research team used a database of known designer drugs – synthetic psychoactive substances – to train the AI on their structures. The market for designer drugs is ever-changing, since their manufacturers are constantly tweaking their formulas to circumvent restrictions and produce new “legal” substances, while cracking their structure takes months for law enforcement agencies, the researchers said.
“The vast majority of these designer drugs have never been tested in humans and are completely unregulated. They are a major public-health concern to emergency departments across the world,” one of the researchers, UBC medical student Dr. Michael Skinnider has said.
After its training, the AI was able to generate some 8.9 million potential designer drugs. Afterwards, researchers ran a data sheet of some 196 new drugs, which had emerged in real life after the model was trained, and found that more than 90% of these have been already predicted by the computer.
“The fact that we can predict what designer drugs are likely to emerge on the market before they actually appear is a bit like the 2002 sci-fi movie, Minority Report, where foreknowledge about criminal activities about to take place helped significantly reduce crime in a future world,” senior author Dr. David Wishart, a professor of computing science at the University of Alberta, has said.
Identifying completely unknown substances remains an issue for the AI, the research team has noted, but they hope it might potentially help with that task, since the computer was also able to predict which formulas of designer drugs were more likely to be created and hit the market. The model “ranked the correct chemical structure of an unidentified designer drug among the top 10 candidates 72 percent of the time,” while throwing in spectrometry analysis, which is an easily obtained measurement, bumped the accuracy to some 86%.
“It was shocking to us that the model performed this well, because elucidating entire chemical structures from just an accurate mass measurement is generally thought to be an unsolvable problem,” Skinnider stated.
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Scientists have used an AI tool to identify which animals are most likely to contract and spread mutated versions of Covid-19. The model highlighted both pets and wild animals as likely reservoirs for the virus.
Using information about their habitats and various biological traits, researchers at the Cary Institute of Ecosystem Studies in New York developed the machine learning tool to figure out which animals had the particular ACE2 protein that the coronavirus was most likely to latch onto.
Out of 5,400 tested, the scientists narrowed it down to 540 mammalian species.
Some of its predictions have been previously documented as transmission risks, for instance, dogs, cats and bats, while farm animals like pigs and exotic zoo animals were surprise additions.
Other expected additions are minks, Sunda pangolins, and 35 species of bats – which are together ranked among the top 10% of animals most likely to spread the virus, in line with lab results.
The study, published in the Proceedings of the Royal Society journal, also ranked water buffalo, a number of primates, including gorillas and 76 rodent species as being more susceptible to infection.
The researchers taught the AI to identify patterns between rates of transmission and some 60 ecological and biological traits collected by earlier studies, including the overlap between the animal and human habitats as well as their respective lifespans, diets, and sizes.
Previously, the specific amino acid sequences had only been mapped out in around 300 species, including about 143 mammals — and figuring out which ones are more prone to infection is key to predicting the spread of the virus, researchers said.
Arinjay Banerjee at the University of Saskatchewan in Canada told the New Scientist that the results will help researchers “track viral infections and the possible emergence of animal-adapted coronavirus variants” around the world. Barbara Han, who led the study, said predictions needed to be followed up with systematic surveillance and lab studies.
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The Funniest Clothing Labels Ever – When was the last time you read the label on your favorite shirt or most comfortable pair of jeans? Maybe it’s time to take a look, your clothing tags may hide a funny message.
The Perfect Gift For Someone You Hate – Hungry AND tired? You can rest on this soft body pillow shaped like smoked pig’s feet! What really amazes us are the details, it looks so real… and so disgusting.
Every Cat at 3AM – If you currently have or have ever had a cat, you’ll be able to relate to Gus Johnson’s video, in which he demonstrates one of the many ways in which our furry friends can be a-holes.
The Funniest Dog Videos Of All Time – We understand the value of a good funny dog video, so here’s a list of our six best viral pup videos of all time. You’re welcome.
Mildly Infuriating Things In Life – Sometimes the internet shows you a photo that’s ever so slightly wrong that it sticks in your brain forever…
Random Funny Pictures – What do you do when you are bored at work? You just mindlessly scroll through random funny pictures, of course!
Mr. Bean Playing Every Role In Hollywood – When one thinks of a rugged, versatile actor capable of elevating any role given to them, Mr. Bean naturally springs to mind. And yet he was never cast as Frodo Baggins or Indiana Jones, which in our eyes is one of the saddest tragedies of modern filmmaking.
Rotterdam Mayor Ahmed Aboutaleb has described an anti-lockdown protest in his city as an “orgy of violence.” The Dutch demonstration devolved into a violent riot that saw police open fire on protesters.
Aboutaleb described the events of Friday night as an “orgy of violence,” after protesters packed Rotterdam’s central Coolsingel shopping street to voice their opposition to an ongoing partial lockdown, a ban on New Year’s Eve fireworks displays, and the possibility of a two-tiered system of freedom in the Netherlands, one of liberty for the vaccinated and restrictions for those without the jab.
The protest soon got out of hand, and police said on Saturday that 57 people were arrested. Protesters were seen torching police vehicles and launching fireworks at police, who shot at them in response.
Aboutaleb said that the cops had been “forced” to use their weapons. “On a number of occasions the police felt it necessary to draw their weapons to defend themselves,” he told reporters. “They shot at protesters, people were injured.”
Police say at least seven people were injured. Two of these injuries were caused by police bullets, and the victims are still in hospital. One officer was hospitalized, while several others were treated at the scene for minor injuries.
People who live in the big cities are definitely masters of eavesdropping. Sometimes they can’t help it, accidentally overhearing conversations from complete strangers can be so funny, it’s hard not to share them with someone else. And here comes the fittingly named Instagram account Overheard San Francisco that’s dedicated to sharing the funniest eavesdropped interactions in San Francisco and the Bay area. Scroll down to see the funniest examples!
At least ten people have been killed and several wounded by security forces during mass demonstrations in Sudan against the recent military coup, a medics organization has said.
“The coup forces used live bullets heavily in different areas of the capital and there are tens of gunshot injuries, some of them in serious condition,” the Central Committee of Sudanese Doctors (CCSD) said in a statement.
The group of medics, which supports the protest movement, said several of the injured were in critical condition. It reported ten deaths across Bahri, Omdurman and the capital Khartoum.
According to AFP, citing witnesses, security forces also fired tear gas at protesters in the capital.
Although internet services have been disrupted and telephone lines cut since the military coup on October 25, thousands of people made it to the streets of major cities.
The Sudanese Professionals Association, which also supports the demonstrators, said people were witnessing “excessive repression” and that there was a “deliberate interruption of voice and internet communications services.”
Videos posted on social media show protesters wrapping up in national flags, chanting anti-military mottos and demanding the release of activists detained by the military since the takeover. Resistance committees across Sudan adopted the Liverpool Football Club’s chant ‘You Will Never Walk Alone’ as their slogan, which has already become a popular hashtag on Twitter.
“The street is calling Thwra (revolution), The revolution says Madaniya (civilian gov)”
On October 25, following a long period of tensions between Sudan’s military and civilian-led government, General Abdel Fattah al-Burhan announced the dissolution of both the Sovereign Council and the transitional government, declaring a state of emergency. The apparent military coup immediately prompted mass protests across the country.
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Sporadic clashes broke out at massive Saturday demonstrations in major European cities, as thousands of people took to the streets of Vienna, Paris and Rome to express their discontent with Covid-19 restrictions.
The Austrian capital Vienna on Saturday saw the largest protest turnout since the start of the Covid-19 pandemic. A total of 38,000 people took to the city streets to join a dozen demonstrations protesting government measures.
Austria se colocó en pleno apartheid sanitario esta semana, mirando a Viena ahora mismo, no lo pensarías, recuerda que dependen únicamente de la conformidad del pueblo, la resistencia es clave. pic.twitter.com/tKRAIJ2GLt
— Creo en la justicia divina y terrenal 💞💞🇪🇸🇪🇸 (@Ninita0011) November 20, 2021
Tens of thousands have taken to the streets today in one of the largest protests in the history of Vienna, Austria, after the government implemented a new COVID lockdown and became the first in the world to announce compulsory vaccination.pic.twitter.com/FFriWCZioG
The protests came a day after the Austrian authorities ordered nationwide compulsory vaccination from February 1 and imposed a full lockdown, starting Monday. The massive procession that spanned over several kilometers marched along Vienna’s central ring road. The city center was paralyzed for several hours as traffic was restricted.
Austria’s right-wing Freedom Party, whose members joined the rallies, put the number of protesters at 100,000. Some demonstrations were also attended by members of various far-right groups. The protests were generally peaceful but footage published by Ruptly video news agency showed several scuffles between the police and the demonstrators breaking out.
Law enforcement spoke of a total of five arrests. One incident saw a protester attempting to grab an officer’s gun and take it from its holster. In another incident, the officers were pelted with bottles and fireworks and had to use pepper spray in response.
#w2011 Die Situation in Wien eskaliert. Die Polizei scheint, trotz der bekannten Grossmobilisierung und zahllosen Gewaltaufrufen, äusserst schlecht vorbereitet. An mehreren Orten wurde die Polizei umzingelt und musste sich zurückziehen. pic.twitter.com/4VzZTbww2S
Hundreds of kilometers away from Vienna, in the French capital Paris, events took a more dramatic turn. There, a demonstration against the government Covid-19 measures coincided with the third anniversary of the Yellow Vests movement. Hundreds of protesters took part in the protest, which quickly turned into clashes between the demonstrators and law enforcement.
The protesters were building barricades and setting them on fire as well as pelting police with bottles and various other projectiles. Law enforcement responded with profuse amounts of tear gas, sometimes filling entire streets with thick smoke to disperse the crowds.
PARIS – Un conteneur est renversé pour utiliser les bouteilles comme projectiles.
Rome saw a massive demonstration against Italy’s Covid-19 health pass, also known as the Green Pass. Some 4,000 people gathered in the center of the Italian capital, according to the police. The demonstrators were waving national flags and chanting “Freedom” and “No Green Pass,” referring to the vaccination certificate needed to enter various public venues such as clubs or bars.
The crowd staged a sit-in in the Circus Maximus – an ancient Roman chariot-racing stadium converted into a modern-day park. They remained there after sunset, lighting the area with thousands of phones and colored smoke bombs. The rally was peaceful, though, as the police did not report any incidents.
Unlike Rome, Italy’s northern city of Milano saw clashes between protesters and the police as law enforcement officers sought to break up an unauthorized rally at the city center. Large police forces were deployed to the city center and several squares were cordoned off.
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Carving the turkey for Thanksgiving is a true honor for any man, and should be taken extremely seriously. Assuming you have no backup turkey, you have one opportunity to slice and carve it just perfectly, or your reputation with your family with be tainted forever. What better way to ensure you carve your Thanksgiving turkey properly and in the most manly way possible than with a chainsaw carving tool?
The electric chainsaw turkey carving tool looks and acts like a real chainsaw, except it won’t actually cut wood, and it’s a much smaller version of its larger counterpart. Though a chain doesn’t wrap around the blade and spin like a real chainsaw, a small electric knife is on the bottom of the blade to make it look like it’s working like a real chainsaw.
Made with stainless steel cutting blades along with an ABS plastic body, the chainsaw inspired turkey carving tool is not only great for cutting turkeys and other birds, but is also useful for cutting melons, pineapples, potatoes, breads, and more.
An exoplanet some 70% the mass of Jupiter and about 1.4 times its size has been discovered by astronomers at India’s Physical Research Laboratory (PRL). The behemoth is 752 light years away from Earth, and has an incredible orbit.
The new discovery was revealed by the Indian Space Research Organization on Tuesday in a statement saying the country’s PRL Advanced Radial-velocity Abu-sky Search (PARAS) had measured the movements of the newly-discovered exoplanet between December 2020 and March 2021.
The planet, named either HD 82139 or TOI 1789 depending on which cataloguing method is used, is ultra-hot – with a surface temperature up to 2,000 degrees Kelvin.
India’s PRL Advanced Radial-velocity Abu-sky Search (PARAS), an optical fiber-fed spectrograph, observed t he exoplanet and its movements from the Mt. Abu Observatory, according to the space agency. Not only is the planet ultra-hot, but it is also one of the closest to an orbiting star yet discovered.
The measurements obtained via PARAS were confirmed by Germany’s TCES spectrograph in April, and further verified by independent photometric observations from the PRL’s 43cm telescope, also located at Mt. Abu.
The exoplanet has an unusually quick orbit – a mere 3.2 days. The pace indicates that its distance from its host star is one-tenth the distance between Mercury and the Sun. This makes the exoplanet one of fewer than 10 such solar systems discovered thus far. Given the closeness to its host star – an aging orb 1.5 times the mass of the Sun – the new planet is also one of the lowest density planets yet discovered.
Planets so close to their host stars, with a distance less than 0.1 AU and masses between 0.25 to several times the mass of Jupiter, are known as “hot-Jupiters.”
The Indian space agency hailed the detection of the new planet as an opportunity to “enhance our understanding of various mechanisms responsible for inflation in hot-Jupiters and the formation and evolution of planetary systems around evolving and aging stars.” It is the second planet to be discovered by PARAS, with a previous discovery taking place in 2018.
Protesters thronged the streets of Australian cities on Saturday, demanding an end to what they called the “tyranny” and “oppression” of lockdowns, vaccine mandates, and the proposed expansion of the government’s pandemic powers.
In Melbourne, Sky News reporter Sophie Elsworth described “tens of thousands of people streaming through the streets.” The march came after a week of smaller protests aimed at Victoria Premier Dan Andrews’ controversial pandemic bill, which if approved by the state’s legislature would allow Andrews and Health Minister Martin Foley to declare an indefinite state of emergency and issue public health orders by decree – including “any order… that the minister believes is reasonably necessary to protect public health.”
Tens of thousands of people keep streaming through the streets. Many I’ve spoken to are concerned about the state govt, Premier, vaccine mandates, the pandemic bill & what future holds for their kids. #melbourneprotestpic.twitter.com/smexulQ4ts
Should the bill pass, it would allow Andrews to target certain classes of people with these orders, categorizing them by age, occupation, or vaccination status. Fines for noncompliance would range from up to AU$21,800 for people and AU$109,000 for businesses.
Alternative media sources claimed that more than 100,000 people showed up to protest. However, the demonstration remained free of the violent clashes seen at protests in Melbourne in recent months.
“Australia has been willing to send troops to all parts of the world to help people become free,” one military veteran told a crowd of listeners during the protest. “To now be fighting oppression here in our own country, it’s saddening.”
Melbourne Australia 🇦🇺
An Aussie veteran is calling former servicemen and cops who have sworn an oath to Australia to stand up against the tyranny 👊 pic.twitter.com/4RsoRMjoJE
Huge numbers of protesters also turned out in Sydney, and although more than 600 police officers were deployed to watch over the gathering, no arrests were made, 9News reported.
Holding signs decrying state “tyranny,” the demonstrators chanted “freedom” and called for the firing of state politicians who have implemented a two-tier system where the unvaccinated are denied many of the privileges extended to the fully jabbed.
Similarly massive gatherings took place in Adelaide, Brisbane, and Perth, with no notable incidents of violence or police action. Further afield, protests are taking place in more than 120 cities around the world this weekend, in a loosely coordinated event dubbed the ‘Worldwide Rally For Freedom’ by activists.
Thousands of people have descended across Rundle Park today as part of an Adelaide freedom rally. Some of those in the crowd say they have lost their job as a result of mandated vaccinations in their sector. @9NewsAdelpic.twitter.com/YdzvxYJhqF
