Pfizer has agreed to grant a royalty-free license to sell its anti-coronavirus pill in nearly 100 developing countries around the world.
Under the agreement signed with the Medicines Patent Pool (MPP), a UN-backed public health organization, Pfizer will not receive royalties on the sales of its promising antiviral pill in 95 poorer countries, including the states of Sub-Saharan Africa. The measure allows MPP to grant sub-licenses to “qualified” generic medicine manufacturers in each country.
The countries covered by the deal comprise around 53% of the world’s population, Pfizer said. “We believe oral antiviral treatments can play a vital role in reducing the severity of Covid-19 infections, decreasing the strain on our healthcare systems and saving lives,” Pfizer CEO Albert Bourla said.
We must work to ensure that all people – regardless of where they live or their circumstances – have access to these breakthroughs.
During its phase-two/three trial, the drug PF-07321332, trademarked as Paxlovid, reduced the risk of hospitalization or death by 89% in Covid-19 patients who took it within three days of symptom onset. The drug is administered in combination with low-dose ritonavir, a medication used to treat HIV/AIDS.
The UN and the World Health Organization (WHO) have long been urging companies to make vaccines and other forms of Covid-19 treatment accessible and affordable for developing countries.
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NEW YORK, Nov 19 (IPS) – A week has gone by since COP 26 with 197 Parties ended in the Scottish city of Glasgow on extended time last Saturday. Climate change which covers wide array of issues affecting all living beings engaged the people around the world for COP 26 in a way never experienced since COP1 was held in Berlin in 1995.
An American nonprofit behind the US-funded bat virus research in China has denied ever sending virus samples from Laos – a place where SARS-CoV-2 closest natural relative was found – to Wuhan in response to fresh allegations.
“No work was ever conducted in Laos as a part of this collaborative research project,” EcoHealth Alliance – a group that conducted experiments on coronaviruses while receiving funding from the National Institutes of Health (NIH) – said in a series of tweets on Sunday, responding to media reports alleging that the group might have transported a potentially dangerous virus from Laos to the laboratory in Wuhan.
However, we considered it a higher priority to continue our focus on China, and no work was ever conducted in Laos as a part of this collaborative research project.
The group’s name surfaced in October when the NIH principal deputy director, Lawrence Tabak, revealed EcoHealth Alliance did experiment on the viruses with the agency’s financial help. At that time, White House Medical Advisor Dr. Anthony Fauci stated that the viruses studied as part of the project “were distant enough molecularly that no matter what you did to them, they could never, ever become SARS-CoV-2.”
EcoHealth has come under renewed scrutiny after its emails, obtained through a Freedom of Information request, appeared to suggest that the group was discussing the prospect of collecting viral samples from bats in Laos and sending them to the Wuhan Institute of Virology. The emails were initially obtained by the White Coat Waste Project and sparked a flurry of reports over the weekend, including in the Spectator by British science writer Matt Ridley.
The emails shared between EcoHealth Alliance and its US government funders reportedly reveal that the scientists discussed collecting viral samples from bats in eight countries, including in Laos, between 2016 and 2019, and toyed with the idea of transporting them to Wuhan, ostensibly, to avoid red tape. One email from 2016 cited by the Spectator reportedly reads: “All samples collected would be tested at the Wuhan Institute of Virology.”
Laos is the birthplace of at least one virus that seems to be very close to SARS-Cov-2. A bat viral strain called Banal-52 discovered in Laos in September shares 96.8 percent of its genome with the virus behind the Covid-19 pandemic
On Sunday, EcoHealth Alliance claimed that the emails cited by Ridley “do not show…that we were sampling bats in Laos and sending the results to Wuhan.”
The group acknowledged, however, that it requested NIH permission to work in Southeast Asian countries, including in Laos, and that this permission was granted.
However, the nonprofit claimed it ended focusing on China instead.
The response failed to satisfy Ridley, who is also a co-author of a book on Covid’s origin, who demanded “evidence” proving that his report was not “fully accurate.”
Despite COVID-19 lockdowns and restrictions, some 650,000 women and girls were provided with gender-based violence services through a joint UN and European Union (EU) programme working to stamp out what is arguably one of the most prevalent human rights violations.
Cipher Brief Expert Tim Willasey-Wilsey served for over 27 years in the British Foreign and Commonwealth Office. He is now Visiting Professor of War Studies at King’s College, London.
Older Americans have Saigon 1975 and the helicopters from the Embassy roof seared into their memories. A previous generation of Britons was haunted by the image of General Percival surrendering vast numbers of troops and equipment in Singapore to the Japanese in 1942. How Kabul falls to the Taliban could have important practical and symbolic significance.
The announcement that the United States is sending 3,000 troops to Kabul alongside 600 British troops to manage the evacuation of their civilians and those Afghans who provided assistance, is a remarkably late response to a rapidly deteriorating situation. Unless carried out in the next 48 hours, it will also be risky. Taliban infiltrators are already inside Kabul and the forces which captured Ghazni and Kandahar on 12th August will be heading towards the capital on their Honda 125cc motorbikes.
The US must have extracted undertakings from the Taliban negotiators in Qatar not to launch their full assault on Kabul until the evacuations are complete, but elements of doubt remain. Previous Taliban assurances have proved worthless, and it is doubtful that individual Taliban commanders would wish to hold back while some of Ashraf Ghani’s ministers, senior army officers, judges and officials are spirited away to a life of exile.
It is hard not to be impressed by the speed and élan of the Taliban’s recent successes; taking 13 of Afghanistan’s 34 regional capitals in almost as many days. It is reminiscent of the extraordinary progress which the Japanese made down the Malaya Peninsula in 1942 with Singapore as the ultimate prize.
The Taliban’s success has not happened by chance. It is clearly the fruit of preparation and planning. Above all, they have learnt from the experience of 1994 to 1996 when they eventually took Kabul but failed to capture the north, thereby allowing space for the Northern Alliance parties to survive and then reassert themselves following the 9/11 terrorist attacks.
This time, the Taliban have focussed first on border posts with neighbouring countries (thereby denying the government vital supply routes and customs revenues) before taking outlying regional capitals and leaving Kabul (which is never easy to capture) until last. Above all, they have concentrated on the north where many rural Afghans are disenchanted with the Kabul government and regional warlords. The north is no longer the solid bastion of anti-Taliban sentiment it was in the 1990s.
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Taliban progress in the north has snuffed out any chance that the old Northern Alliance could be reborn out of the eventual collapse of the Ashraf Ghani government. Whereas in 1996, Ahmed Shah Massoud, its brilliant military leader, was able to abandon Kabul and beat a tactical retreat up the Panjshir Valley, that option barely exists today. Not only is Massoud dead but his former adherents are no longer guerrilla fighters but members of a stratified Afghan army which has struggled to perform without US air support.
The Taliban have also ruthlessly exploited the weak negotiating stance of the United States and its chief negotiator Zalmay Khalilzad. Whereas some of the Taliban team in Doha, such as Mullah Barader, may indeed have been ‘moderates’ there was never any doubt that the Taliban movement wanted to see the total defeat of the Kabul government and the expulsion of Western forces. Pakistan too, may have occasionally considered some form of negotiated deal but ultimately the only sure way of keeping Indian influence out of Afghanistan (it believes) is a Taliban government.
The Afghan army (and in particular its impressive Special Forces) will now be assembling in Kabul and should be able to repel initial attempts to overrun the city. Certainly, Gulbuddin Hekmatyar found it impossible to take Kabul in 1992 and 1993 even with help from Pakistan, which, in frustration, switched support to the newly-created Taliban movement in late 1994.
But from 1992 to 1996 there were frequent deliveries of supplies to Massoud and his Northern Alliance defenders from Russia, Iran, and India. In 2021, the position is very different. Russia has already decided to “back the winner” and believes it has extracted promises from the Taliban not to export Islamism northwards into the Central Asian Republics (CARs). Iran too has channels to the Taliban and will be watching carefully for any return to the Taliban’s persecution of the Shia Hazaras. And India has already made contact with the Taliban in Doha in the hope that the Taliban in power will prevent Kashmiri militant groups from setting up bases there.
The likelihood therefore is that Kabul will fall to the Taliban quite quickly. If the Americans and British do manage to insert their evacuation forces soon, they should be able to complete the operation successfully, although there are likely to be heart-rending scenes at the airport as crowds of refugees are turned away at gunpoint from departing aircraft. Regional powers, particularly Pakistan, will try and persuade the Taliban to hold back from intervening, conscious that a bloodbath in Kabul would be a disastrous start to the Taliban’s second spell in government. Ironically, however, the evacuation would almost certainly lead to the collapse of the Kabul government as senior officials are forced to decide whether to take the last aircraft out or face almost certain torture and death at the hands of the victors. It is doubtful whether any Western countries will choose to retain their embassies in Kabul. For President Biden, the memory of Benghazi will be too raw.
What is certain is that there will be new iconic images to rival those of Saigon and Singapore.
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China has accused the Philippines of breaching its territory, saying two supply ships were blocked by Beijing’s coast guard as they approached a disputed shoal. Manila protested over the run-in, citing its own claim to the area.
The two Philippines vessels “trespassed” into waters near the Nansha island chain – also known as the Spratly Islands – on November 16, Foreign Ministry spokesman Zhao Lijan told reporters on Friday, noting that they entered the area “without China’s consent.”
“Chinese coast guard vessels performed official duties in accordance with law and upheld China’s territorial sovereignty and maritime order,” Zhao said, adding that the area is now “generally tranquil” and that the two countries are in communication about the encounter.
The comments from Beijing come just one day after Manila first publicized the incident, with the Philippines Foreign Affairs Secretary Teodoro Locsin claiming Chinese vessels fired water cannon on the two supply boats and forced them to abandon their mission near a disputed shoal in the Spratlys. He called on China to “back off” and “take heed” of Philippines claims to the region.
While both countries regard the Ayungin shoal – alternatively referred to as the Second Thomas or Renai Jiao shoal – as their own territory, The Hague’s Permanent Court of Arbitration settled the dispute in the Philippines’ favor in 2016. However, despite that ruling, as well as the fact that Manila has maintained a presence on the shoal since 1999, Beijing has not abandoned its claims to the area.
The EU Commission has released draft legislation aimed at tackling the destruction of woodland by introducing import restrictions on products not certified as ‘deforestation-free’.
The draft proposal, which the commission hopes will become binding rules for all member states, seeks to limit the import of beef, cocoa, coffee, palm, soy, and wood if it is not proven “deforestation-free.”
Outlining the legislation, the EU commissioner for climate action policy, Virginijus Sinkevicius, called it a “ground-breaking” proposal that will help fight “illegal deforestation” and “deforestation driven by agricultural expansion.”
Our proposal to fight deforestation will help us protect 1/3 of 🌎 lands.
We don’t only target illegal deforestation but 𝙖𝙡𝙡 deforestation driven by agricultural expansion.
We start with 6 products that must be deforestation-free 👉🏼 beef, wood, palm oil, soya, coffee, cocoa. pic.twitter.com/Cs9POoydNX
The bill comes after nations at the COP26 summit agreed to work to end deforestation by 2030. It would impose two criteria on imports, requiring items to have been produced in accordance with the origin country’s laws, and not on land that has been deforested or degraded since the start of 2021.
It is not clear when the rules would come into effect; legislative proposals by the commission have to be debated and considered by both the EU Parliament and the Council of the EU before they are passed. The implementation of measures could potentially impact the EU’s trade relations with countries like Brazil, where clearing of the Amazon rainforest hit a new record in October.
During the recent COP26 climate summit, 110 world leaders – whose countries contain around 85% of the world’s woodland – committed to ending and reversing deforestation by 2030, pledging around £14 billion ($18.84 billion) of public and private funds towards the goal.
Instagram is looking to channel the anger of its users by introducing a new feature that allows them to report various problems with the app by shaking their phones.
“Have you ever used Instagram and it wasn’t working like it was supposed to? It was just really getting you… really just pissing you off?” Instagram’s head Adam Mosseri asked his followers in a clip uploaded to Twitter on Wednesday.
Well, precisely for infuriating situations like that, the platform has developed a feature it’s calling “rage shake,” he announced.
Shaking your phone will, from now on, cause a special form to pop up on screen, allowing you to instantly report issues such as photos not uploading or audio not playing.
The form is also the perfect place to let out “all the emotions and feels you’ve got going on,” Mosseri insisted, assuring Instagrammers that these reports would be promptly dealt with.
Thanks to their feedback, Instagram will be able to optimize its bug-fixing process, he said. The option, which he described as a “hidden gem,” is so far available only in the US, on both iOS and Android.
The Instagram boss gently shook his own cellphone in the clip to demonstrate the feature in action. However, it’s likely upset users may well end up rage-shaking with a good deal more passion, which could increase the risk of a gadget being damaged, or their owner or even a passerby being struck should the phone fly out of their hand.
Mosseri also didn’t advise the public what to do with their rage over media revelations about alleged shady practices by Instagram and the platform’s owner, Facebook.
Among the trove of papers recently leaked by former Facebook employee Frances Haugen was an internal study from 2020 reporting that Instagram was causing many of its young users, particularly teen girls, to suffer mental health issues and suicidal thoughts. However, the platform kept operating in the same manner despite this finding, with changes being promised only after the study made headlines this September.
Protesters thronged the streets of Australian cities on Saturday, demanding an end to what they called the “tyranny” and “oppression” of lockdowns, vaccine mandates, and the proposed expansion of the government’s pandemic powers.
In Melbourne, Sky News reporter Sophie Elsworth described “tens of thousands of people streaming through the streets.” The march came after a week of smaller protests aimed at Victoria Premier Dan Andrews’ controversial pandemic bill, which if approved by the state’s legislature would allow Andrews and Health Minister Martin Foley to declare an indefinite state of emergency and issue public health orders by decree – including “any order… that the minister believes is reasonably necessary to protect public health.”
Tens of thousands of people keep streaming through the streets. Many I’ve spoken to are concerned about the state govt, Premier, vaccine mandates, the pandemic bill & what future holds for their kids. #melbourneprotestpic.twitter.com/smexulQ4ts
Should the bill pass, it would allow Andrews to target certain classes of people with these orders, categorizing them by age, occupation, or vaccination status. Fines for noncompliance would range from up to AU$21,800 for people and AU$109,000 for businesses.
Alternative media sources claimed that more than 100,000 people showed up to protest. However, the demonstration remained free of the violent clashes seen at protests in Melbourne in recent months.
“Australia has been willing to send troops to all parts of the world to help people become free,” one military veteran told a crowd of listeners during the protest. “To now be fighting oppression here in our own country, it’s saddening.”
Melbourne Australia 🇦🇺
An Aussie veteran is calling former servicemen and cops who have sworn an oath to Australia to stand up against the tyranny 👊 pic.twitter.com/4RsoRMjoJE
Huge numbers of protesters also turned out in Sydney, and although more than 600 police officers were deployed to watch over the gathering, no arrests were made, 9News reported.
Holding signs decrying state “tyranny,” the demonstrators chanted “freedom” and called for the firing of state politicians who have implemented a two-tier system where the unvaccinated are denied many of the privileges extended to the fully jabbed.
Similarly massive gatherings took place in Adelaide, Brisbane, and Perth, with no notable incidents of violence or police action. Further afield, protests are taking place in more than 120 cities around the world this weekend, in a loosely coordinated event dubbed the ‘Worldwide Rally For Freedom’ by activists.
Thousands of people have descended across Rundle Park today as part of an Adelaide freedom rally. Some of those in the crowd say they have lost their job as a result of mandated vaccinations in their sector. @9NewsAdelpic.twitter.com/YdzvxYJhqF
As infections are rising again, scientists all around the world are rushing to fight the danger, offering a choice of new treatments and unusual variants of vaccines.
Levels of contagion are setting new records, hospitals are overwhelmed, governments are starting to introduce lockdowns, and not only for unvaccinated people – the picture of the fight against Covid-19 looks quite disappointing. However, there’s still a place for good news: Research teams report positive results while trialling new medicines and vaccine types.
Nasal vaccines
Vaccination will remain one of the most effective tools against Covid-19. As Professor David Dockrell, from the Center for Inflammation Research of the University of Edinburgh, told RT, “vaccines will continue to be a central part of how we control the virus.”
“If we can dampen down the number of infections, and the severity of infections, and also the extent to which the virus can replicate in people when they become infected, then we are slowing down the ability of the virus to change and to mutate,” he explains.
So I think the vaccines still will be a very important part of the preventive strategy. It’s vital that they are available to all the world’s population, irrespective of where people live, and the wealth of the country in which they live.
However, vaccination doesn’t always mean you have to get an injection. For instance, several intranasal Covid-19 vaccines are currently being developed. As the virus gets into the body through the nose, a nasal spray or drops are aimed to produce mucosal immune response and prevent it from getting into the lungs.
In India, a vaccine of this type is already completing Phase 2 of clinical trials. In Russia, a nasal vaccine is undergoing a clinical trial on volunteers. In Thailand, a home-developed product is expected to be trialed on humans next spring. In the US, Universities of Houston and Stanford recently reported good results of their experiments carried out on mice.
Intranasal vaccines can have several potential benefits compared to inoculation.
“They would be easier to use, because they can be self-administered. They wouldn’t need a nurse or clinical settings,” Swedish professor emeritus of epidemiology Marcello Ferrada de Noli explained to RT. As a result, he says, there’s hope that fewer people will be reluctant to be immunized. Not so many of us find it pleasant to get a jab – and after all, there are those who are just afraid of needles. Also, it would be much easier to vaccinate children with nasal substances.
However, what concerns Prof. de Noli the most is the duration of the effect of a vaccine of this type. Still, scientists can’t say for sure whether a nasal substance may completely replace a shot. According to Alexander Gintsburg, the head of Moscow’s Gamaleya Center biomedical research institute, which created the Sputnik V vaccine, the nasal version they are working on would serve for an additional protection against the virus, but would not replace the injections.
Chew the virus away?
A nasal vaccine is not the only one being developed. In summer, it was revealed that Russian Defense Ministry scientists were creating a ‘chewing gum’ vaccine, also targeting the mucosal immune response. Meanwhile, a UK firm announced this month that it would conduct a human trial of a skin patch that uses T-cells to confront the virus. Developers hope it would offer longer-lasting immunity than the existing vaccines. Work on a similar project is being done in the University of Queensland, Australia.
While it all looks so promising, Prof. de Noli warns that it would still take a lot of time until these products become available to the public. “I think that discoveries in this field are a very good thing. But if we say ‘We discovered a new type of vaccine’, people will say ‘Aha, so I’m going to wait’. But we need to vaccinate people now,” he points out.
Improving Covid treatment
Vaccines are not a silver bullet, unfortunately, given the not-so-high level of global immunization and the constantly emerging new strains of the virus. “People might get infected despite having had a vaccine, but I still think the vaccine strategy is going to be central to how we manage this kind of virus going forward,” Prof. Dockrell says. “But we will have other strategies that will be very important. We will have other elements. When we put them all together, it gives us the best opportunity that people can live with coronaviruses, and hopefully, the mortality can be limited to much lower extense than what we’ve sadly seen in the last eighteen months.”
Monoclonal antibodies will be central to the ongoing vaccine strategy, Prof. Dockrell explains. These are the antibodies similar to those the body uses to fight the virus. They are produced in labs and given via infusion or injection to boost the patient’s response against certain diseases. Monoclonal antibody treatment is used for people under a high risk of developing severe infection (including older patients 65+ years old or those with chronic medical conditions). It’s already being used in the US, following last year’s FDA approval. Earlier in November, the European Medicines agency recommended authorizing two monoclonal antibody medicines.
In October, UK’s AstraZeneca reported positive results of a Phase 3 study of its antibody combination, which, according to developers, is highly effective in both prevention and treatment of coronavirus.
Researchers are also working on a possibility to save Covid-infected patients from the so-called ‘cytokine storm’ – a situation when the immune system reacts so intensely that kills not only the virus, but the whole organism itself. A drug to ‘calm the storm’ was registered in Russia this year, and it’s already being used on patients.
Another way to fight Covid-19 is to use antiviral drugs. When the pandemic started, medics had to use something already existing (like anti-influenza Favipiravir) or something being authorized for emergency use (like remdesivir). Now, more than a year on, the work to create a special drug to specifically cure Covid-19 is giving its results. This month, Russia registered its first injectable anti-Covid medicine. A bit earlier, the UK became the first country to approve an antiviral pill produced by the US-based companies Merck and Ridgeback Biotherapeutics. Another American firm, Pfizer, got positive results from trials of its drug of the same kind. Both firms hope that with a drug in the form of a pill it would be easier to treat people at home.
Appreciating all the efforts on the field of developing anti-Covid treatment, Prof. de Noli points out that still, the key issue now is to reduce the spreading of the virus. “The new medicines are developed for people who already got the disease,” he says.
But we need to prevent people from getting the infection, not let them get infected because we have some new medicine that can cure them.
The same idea is echoed by scientists all over the world quoted in plenty of articles dedicated to the medical gains: it’s great to have the treatment, but none of the drugs may substitute vaccination, as first and foremost, humanity has to adopt preventive measures and stop the pandemic.
