Scientists in Sweden claim that a single protein in the blood could predict the onset of Type 2 diabetes nearly 20 years in advance. The breakthrough potentially affects hundreds of millions of people worldwide.

Diabetes is the world’s ninth-leading cause of death, and affects nearly half a billion people worldwide, according to the World Health Organisation (WHO). The vast majority of diabetes patients suffer from Type 2 diabetes, a condition that can lead to blindness, kidney failure, heart attacks, strokes, and lower limb amputation. Cases of diabetes quadrupled worldwide between 1980 and 2014, with unhealthy diets and lack of exercise blamed for the rise.

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© Getty Images / Peter Dazeley
NHS setting up fat camps for children

However, researchers at Lund University in Malmo, Sweden claim that elevated levels of a certain protein – follistatin – in the blood can predict the onset of Type 2 diabetes regardless of a person’s age, weight, diet or activity level. In a study published last week, the scientists wrote that high levels of follistatin can predict the condition up to 19 years before symptoms appear.

To discover the link between follistatin and diabetes, the researchers tracked 5,300 people from Sweden, Italy, and the UK for between four and 19 years. Follistatin helps break down body fat, while simultaneously leading to an increase in fat in the liver. This buildup can cause fatty liver disease and Type 2 diabetes.

“This study shows that follistatin has the potential to become an important biomarker to predict future Type 2 diabetes, and it also brings us one step closer to the understanding of the mechanisms behind the disease,” Dr. Yang De Marinis, associate professor at Lund University and lead author of the study, told a university newsletter. De Marinis added that the next step for her team would be to help develop an AI-based diagnostic tool that could analyze a patient’s blood sample and use their follistatin levels – and other biomarkers – to calculate their “risk score” for Type 2 diabetes.

As follistatin levels rise in response to food intake and activity levels, the same advice for prevention of diabetes still applies. “Balanced meals, eat[ing] healthy and regular exercise are important to decrease the risk of developing Type 2 diabetes,” De Marinis told StudyFinds.

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Vaccination of all Hungarian citizens against Covid-19 is inevitable, PM Viktor Orban has said, stating that even the most hardline anti-vaxxers will ultimately face a choice between dying with the virus and getting a jab.

Speaking to Kossuth radio on Friday, the Hungarian leader lashed out at those reluctant to get vaccinated against coronavirus, branding them a threat “not only to themselves but to all others.”

In the end, everyone will have to be vaccinated; even the anti-vaxxers will realize that they will either get vaccinated or die. So, I urge everyone to take this opportunity.

The EU member state is currently experiencing its fourth wave of coronavirus, Orban stated, blaming the situation on those who had not got vaccinated. “If everybody were inoculated, there would be no fourth wave or it would be just a small one,” the PM claimed.

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FILE PHOTO. ESSEN, GERMANY. © AFP / Ina FASSBENDER
Covid rates take Germany to ‘nationwide state of emergency’

Apart from urging the unvaccinated to go and finally get their jabs, Orban also promoted booster shots, revealing that he had already taken three doses of a coronavirus vaccine.

“The only thing that protects us from the virus is vaccination. And we are now also seeing, at least the experts are unanimous in saying, that four to six months after the second vaccination, the protective power of the vaccine weakens. Therefore, a third vaccination is justified,” he said.

Hungary has already announced new anti-Covid measures, though somewhat short of the strict measures proposed by the nation’s Medical Chamber on Wednesday. The medical body called for a blanket ban on mass events, and suggested making entry to restaurants, theaters and other indoor venues conditional on bearing a Covid-19 inoculation certificate. Instead, Budapest rolled out compulsory mask wearing for most indoor environments, as well as making booster shots mandatory for all medical workers, starting from Saturday.

A nation of 10 million, Hungary’s total tally of logged Covid cases is hovering just below the one million mark. On Friday, it registered a new daily record, with nearly 11,300 new Covid infections. More than 32,700 people in Hungary have succumbed to the disease over the course of the pandemic.

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We’re starting a new segment on The Cipher Brief’s Open-Source Collection Podcast and adding to the line-up of curated headlines we bring you from around the world with expert insights on today’s news. 

The Cipher Brief’s Brad Christian talked with former CIA Officer Marc Polymeropoulos this week about what’s next for the US Government when it comes to investigating ‘Havana Syndrome’, making sure Afghan interpreters aren’t left behind and why a White House visit by Jordan’s King Abdullah was a bigger deal than some may realize.  

Cipher Brief Expert Marc Polymeropoulos served 26 years in the CIA before retiring from the Senior Intelligence Service in June 2019.  His positions included field and headquarters operational assignments covering the Middle East, Europe, Eurasia and Counterterrorism. 

Christian: What’s top of mind for you this week in the world of national security?

Polymeropoulos:  Havana Syndrome, CIA’s response to the Afghan withdrawal, and the visit of Jordan’s King Abdullah to D.C. Let’s start with Havana Syndrome.

You saw in the press the last couple of days, the notion that the CIA’s inspector general is conducting a review of CIA’s handling of healthcare, of how officers were coming to them starting in 2016 after these attacks started in Cuba. I think that’s a good thing. It’s a necessary evil. I think a lot of your listeners and readers know that I was affected by this in December of 2017. It caused my retirement in July of 2019. I’ve been very vocal on the need for healthcare for our officers.  We have to think about Havana Syndrome in three bins.

The first, is accountability and that’s good. It’s a necessary evil, but we have to look at how the agency responded to officers because that’s critical. The agency workforce is watching. I think the IG review by the CIA is good as well as a look at what’s happening in the House and Senate oversight committees as well.

The second, is continued healthcare for officers, the officers getting to Walter Reed’s National Intrepid Center of Excellence. CIA Director Bill Burns is doing that, so that’s positive.

And then the last piece is culpability. I think you also saw recently in the press, that a senior intelligence service officer who was integral in the hunt for Osama bin Laden, has been named to the task force. So, a lot of stuff is happening on Havana Syndrome, I think all of it is moving in a positive direction. I applaud Director Burns. This is something that I think is going to be at the top of the news cycle for days, weeks, and months to come.

Christian: Do you feel like now there’s a unified awareness at the entire government level outside of CIA?  Is Congress focused on this? Is the White House focused on this in the ways that you think they need to be?

Polymeropoulos: What a great question. The White House for sure. Congress has been absolutely integral both in the Senate and the House. They’re about to pass the Havana Act, which is going to provide financial relief for officers affected, but in all US government agencies. I will say that the Department of State has been woefully behind and that’s a big concern of mine. I feel for my State colleagues. There are 41 State Department officers who have been affected by this. Secretary of State Blinken has not even met with them while Director Burns has met with nearly all of the CIA victims, so State’s got a long way to go. I think we’ll look to the White House and to Congress to keep the pressure on.

Christian: These are events that are still occurring, even as they’re being investigated. Tell us a little bit about the latest that’s happened on the attack front.

Polymeropoulos: I think you see what the press reports of what can only be considered a kind of slow-rolling mass casualty event in Vienna, Austria. There were numerous State Department and intelligence officers affected at our Embassy there. Again, this is coming out in the press, so it’s important to note that. But these things are still happening and I think that we have to look back to the old counter-terrorism model that CIA employed so effectively of detect, disrupt, and deter attacks by our terrorist adversaries. We have to apply that same type of mindset to this problem set.


Go beyond the headlines with expert perspectives on today’s news with The Cipher Brief’s Daily Open-Source Podcast.  Listen here or wherever you listen to podcasts.


Christian: The Afghanistan withdrawal, there’s a lot going on there. We’ve seen reports of US airstrikes supporting Afghan forces in Kandahar. This week, it was reported that just under 50 Afghan troops requested refuge in Pakistan when their border posts near Chitral, which is a Pakistani city, was overrun. The Pakistani government let them in. And we’re seeing now an Afghan strategy focusing on protecting the capital regions and maybe ceding some of those provincial capitals.

Polymeropoulos: I look at this from a narrow optic. As a former CIA officer who was the base chief in Afghanistan between 2011 and 2012, I ran one of our paramilitary bases in eastern Afghanistan along the border with Pakistan. What is unique about life as a CIA officer out in the field, particularly in the bases, was that there were only a few of us. We had a very small number of Americans, yet we had hundreds, if not over 1,000 Afghanistan indigenous personnel, whether they were troops who were fighting with us or whether they were support personnel.  We lived with them. I think this is a little bit different than perhaps big US military’s experience with the Afghan national army.

I trusted my life to these guys. They were armed in front of us all the time. We ate together at the mess hall. We sat around the fire pit together, certainly went on patrols together. So, it’s really personal for me. I remember our Afghan interpreters. I remember our indigenous personnel and I really worry about them. The future, I think is one that certainly is bleak. I don’t support the administration’s decision for a full withdrawal. I don’t understand why we couldn’t have left a residual force, but that policy decision has been made.  I think that the things I’m looking to in the near future are even after the end of August, will the US military still conduct airstrikes in support of Afghan forces?  There is something about betraying those who really made that pact with us. That’s just something as a CIA officer that’s ingrained in us that we don’t want to do that. So, this is something I really worry about. I remember the faces of our interpreters and indigenous personnel every day. These were great heroes. I think a lot of us at CIA wouldn’t be alive today without their heroism.


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Christian: The third issue you raised was interesting, the visit to D.C. by Jordan’s King Abdullah. It didn’t get a lot of press.  But you say it’s a significant story.  Tell us why.

Polymeropoulos: President Biden has had a long-standing relationship with King Abdullah. It’s a sign that Jordan is back. We call Jordan the lily pad for the United States for a lot of reasons. I mean, when you think back to 2006 and Jordan’s integral role in the Anbar Awakening, that’s when we were rallying the tribes in Iraq to fight terrorism. When you think about how the US has access to strategic bases in Jordan and when you think about the Jordanian General Intelligence Directorate as one of the US Government’s most critical counter-terrorism partners. But the fact of the matter is that under the last administration, Jordan was not treated well, so it’s really significant that Abdullah was here. I think this is a really good thing. Don’t forget that CIA Director Bill Burns was ambassador in Amman quite some time ago. I think this is a really positive development, not only for the United States going back to an old strategic partner, but also for Jordan as well, which has been a steadfast ally not only during King Abdullah’s reign, but also of course, under King Hussein before him.

Read more expert-driven national security insights, perspective and analysis in The Cipher Brief

The post An Open-Source Brief: former CIA Officer Marc Polymeropoulos appeared first on The Cipher Brief.

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The Funniest Clothing Labels Ever – When was the last time you read the label on your favorite shirt or most comfortable pair of jeans? Maybe it’s time to take a look, your clothing tags may hide a funny message.

The Perfect Gift For Someone You Hate – Hungry AND tired? You can rest on this soft body pillow shaped like smoked pig’s feet! What really amazes us are the details, it looks so real… and so disgusting.

Every Cat at 3AM – If you currently have or have ever had a cat, you’ll be able to relate to Gus Johnson’s video, in which he demonstrates one of the many ways in which our furry friends can be a-holes.

The Funniest Dog Videos Of All Time – We understand the value of a good funny dog video, so here’s a list of our six best viral pup videos of all time. You’re welcome.

Mildly Infuriating Things In Life – Sometimes the internet shows you a photo that’s ever so slightly wrong that it sticks in your brain forever…

Funny Images Showing How Differently Men and Women Act – Yup, we’re different and there is no denying that fact. We have different bodies, different brains and different ways of using both.

Dads Who Didn’t Want The Damn Dogs In Their Lives – Dad logic is a weird thing. They say they hate dogs, and then you end up with a gallery like this…

Random Funny Pictures – What do you do when you are bored at work? You just mindlessly scroll through random funny pictures, of course!

Mr. Bean Playing Every Role In Hollywood – When one thinks of a rugged, versatile actor capable of elevating any role given to them, Mr. Bean naturally springs to mind. And yet he was never cast as Frodo Baggins or Indiana Jones, which in our eyes is one of the saddest tragedies of modern filmmaking.

Funny Thanksgiving Cake Fails – Thanksgiving is a day to reflect and enjoy time with family… and sometimes to FAIL.

Still bored to tears and want to see more funny and entertaining links? You should check out Linkiest, Leenks, or Fark!

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People around the world will need to get a jab against Covid-19 once a year, at least when it comes to the Pfizer vaccine, BioNTech’s CEO Ugur Sahin said in an interview on Sunday, as he praised the quality of its booster shot.

In an interview with Germany’s Bild newspaper on Sunday, Sahin said he considers the vaccine, co-developed by his company, to be “very effective.”

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© Getty Images / sasacvetkovic33
Drastic drop in Covid vaccine effectiveness – study

When asked whether people should be worried about the “breakthrough infections” – in which those vaccinated with the Pfizer-BioNTech vaccine still developed Covid-19 symptoms – he dismissed such concerns, saying that the jab offers a “90 percent protection” against cases that require intensive care in those aged over 60.

A “very high” level of protection against severe illness lasts for up to nine months, the BioNTech CEO maintained. He said this level starts decreasing “from the fourth month,” however. To maintain the protection, Sahin strongly pushed for booster shots, arguing that they would not just restore levels of antibodies but would potentially help “to break … chains of infection.”

He also encouraged doctors to be “as pragmatic as possible” when it comes to greenlighting vaccination and “not to send people home unvaccinated even though they could be vaccinated without any problems.”

In the future, people might need to get booster shots once a year, the BioNTech CEO believes. He said that he expects protection from a booster shot to “last longer” than the initial immunity one acquires after getting two doses of the vaccine.

“Subsequent … vaccinations may only be needed every year – just like [with] influenza,” he said. Currently, the German Federal Center for Health Education – an agency subordinated to the Health Ministry – recommends a booster shot six months after one gets the second dose of a vaccine. It also says that “booster vaccination makes sense after a minimum interval of about four months.”

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© AFP / MARTIN BERNETTI
FDA approves Covid booster shots for all US adults

Sahin’s interview comes days after it was revealed that Pfizer, BioNTech and Moderna are making a combined profit of $65,000 every minute – all thanks to their Covid-19 jabs. That is according to estimates made by the People’s Vaccine Alliance (PVA) – a coalition demanding wider access to vaccines.

The PVA estimated that the three companies are to earn a total of $34 billion in combined pre-tax profits this year alone, which roughly translates into more than $1,000 a second and $93.5 million a day.

PVA has slammed the three companies over their refusal to allow vaccine technology transfer despite receiving a combined $8 billion in public funding. Such a move could increase global supply and save millions of lives as well as drive down prices, the coalition said.

“Pfizer, BioNTech and Moderna have used their monopolies to prioritize the most profitable contracts with the richest governments, leaving low-income countries out in the cold,” said Maaza Seyoum of the African Alliance and People’s Vaccine Alliance Africa.

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The EU must quickly seal its external borders to stem the flow of migrants who are no longer welcome in the 27-member bloc, according to Slovenia’s interior minister, whose country currently holds the presidency of the EU Council.

Speaking at the ‘Sarajevo Migration Dialogue’ on Thursday, Interior Minister Ales Hojs said EU countries were preoccupied recently with the coronavirus pandemic, the fall of the government in Afghanistan, and now a migrant crisis on the Poland-Belarus border, which he said was a hybrid war waged by Minsk against the EU.

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Migrants gather on the Belarusian-Polish border on November 15, 2021. © AFP / OKSANA MANCHUK; (inset) German Chancellor Angela Merkel. © AFP / MARKUS SCHREIBER
Germany agreed on plan to open humanitarian corridor for refugees on Poland-Belarus border – Minsk

“All three have additionally contributed to the increase in numbers of illegal migrants moving towards Europe and the Balkans, destabilizing the European Union,” Hojs told reporters.

The Slovenian minister said the current situation was similar to the 2015 influx of refugees and migrants from the Middle East and North Africa, when the EU admitted over one million people across its borders.

This time the situation is different, Hojs said, warning that “there is no more ‘refugees welcome.’”

“I believe that external borders must be secured, even with fences if necessary,” Hojs said, saying that he supported a plan for Brussels to finance the building of fences to reinforce the bloc’s borders.

He said it was important to strengthen cooperation and partnership across the EU in order to better manage migration and maintain security.

Thousands of migrants have been trying to cross the Belarus-Poland border in an attempt to reach the EU. They have been stranded at barbed-wire fencing with Polish border guards repelling their attempts to cross. Warsaw has accused Belarus of orchestrating the crisis to destabilize the EU and “weaponize” migration in an effort to have sanctions lifted.

A spokesperson for Belarusian leader Alexander Lukashenko claimed on Thursday that Germany agreed to open a humanitarian corridor for 2,000 refugees on the border.

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All cities and towns in China, as well as “most” villages, will be covered by 5G networks by 2025, the Ministry of Industry in Beijing has announced in a new infrastructure development plan.

Under the plan, the number of 5G base stations per 10,000 people will be increased to 26, and gigabit optical fiber networks will be extended to most urban and rural areas of China, the Ministry of Industry and Information Technology (MIIT) announced on Tuesday.

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Digital infrastructure has been defined as a “strategic, basic and pioneering industry to help build a new type of digital infrastructure and support economic and social development,” according to MIIT official Xie Cun. 

Information technology will be “deeply integrated” with the economy and society, with the goal of spurring internet innovation and creating a business boom, the ministry added. Meanwhile, the authorities are working on “a new type of supervision system” as well as measures to protect users’ personal information and data.

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The EU must quickly seal its external borders to stem the flow of migrants who are no longer welcome in the 27-member bloc, according to Slovenia’s interior minister, whose country currently holds the presidency of the EU Council.

Speaking at the ‘Sarajevo Migration Dialogue’ on Thursday, Interior Minister Ales Hojs said EU countries were preoccupied recently with the coronavirus pandemic, the fall of the government in Afghanistan, and now a migrant crisis on the Poland-Belarus border, which he said was a hybrid war waged by Minsk against the EU.

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Migrants gather on the Belarusian-Polish border on November 15, 2021. © AFP / OKSANA MANCHUK; (inset) German Chancellor Angela Merkel. © AFP / MARKUS SCHREIBER
Germany agreed on plan to open humanitarian corridor for refugees on Poland-Belarus border – Minsk

“All three have additionally contributed to the increase in numbers of illegal migrants moving towards Europe and the Balkans, destabilizing the European Union,” Hojs told reporters.

The Slovenian minister said the current situation was similar to the 2015 influx of refugees and migrants from the Middle East and North Africa, when the EU admitted over one million people across its borders.

This time the situation is different, Hojs said, warning that “there is no more ‘refugees welcome.’”

“I believe that external borders must be secured, even with fences if necessary,” Hojs said, saying that he supported a plan for Brussels to finance the building of fences to reinforce the bloc’s borders.

He said it was important to strengthen cooperation and partnership across the EU in order to better manage migration and maintain security.

Thousands of migrants have been trying to cross the Belarus-Poland border in an attempt to reach the EU. They have been stranded at barbed-wire fencing with Polish border guards repelling their attempts to cross. Warsaw has accused Belarus of orchestrating the crisis to destabilize the EU and “weaponize” migration in an effort to have sanctions lifted.

A spokesperson for Belarusian leader Alexander Lukashenko claimed on Thursday that Germany agreed to open a humanitarian corridor for 2,000 refugees on the border.

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Talk about a gift that keeps on giving; each month reveals yet another beautiful pooch answering nature’s call. Also important: $1 from each “Pooping Pooches 2022” calendar is donated to the Maui Humane Society to support animals in need. This tasteful calendar is available on Etsy and Amazon, but you can also get 500 piece jigsaw puzzle for those long, dark winter evenings!

Pooping Pooches 2022 calendar.

Pooping Pooches 2022 calendar.

Pooping Pooches 2022 calendar.

Pooping Pooches 2022 calendar.

Pooping Pooches 2022 calendar.

Pooping Pooches 2022 calendar.

Pooping Pooches 2022 calendar.

Pooping Pooches 2022 calendar.

Pooping Pooches 2022 calendar.

Pooping Pooches 2022 calendar.

Pooping Pooches 2022 calendar.

Pooping Pooches 2022 calendar.

Pooping Pooches 2022 calendar.

This year’s latest addition is a 500 piece jigsaw puzzle which can also be purchased on Amazon (not suitable for babies and individuals who have a tendency to put things in their mouth and potentially choke on the pieces).

Pooping Pooches jigsaw puzzle.

Pooping Pooches jigsaw puzzle.

Just like the calendar, every puzzle sale will also contribute to Maui Humane Society to help animals in need (one poop at a time).

Pooping Pooches helps animals in need.

Anyways, if pooping dogs is something you would like to look at for a whole year, you can get this calendar on Etsy or Amazon.

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The Swedish government has announced plans to introduce mandatory Covid-19 passes starting next month, amid rising infection rates in Europe. The passes will be required to attend any indoor event with 100 or more participants.

The upcoming introduction of mandatory coronavirus vaccine passes was announced by Health Minister Lena Hallengren on Wednesday.

Citing the ongoing surge in coronavirus cases across Europe – which has not hit the country itself yet – the minister stressed the need to be ready for the new wave of infections, projected to reach Sweden mid-December.

“The spread is increasing in Europe. We haven’t seen it yet in Sweden, but we are not isolated,” Hallengren told a news conference. “We need to be able to use vaccination certificates.”

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© Getty Images / picture alliance
German media reveals jail terms for fake Covid certificates

Starting from December 1, the documents confirming a person’s vaccination status will be a requirement to enter any indoor event with 100 or more people in attendance. Sweden already boasts high vaccination rates, with 85% of its citizens aged over 16 having received at least one dose of a Covid-19 vaccine. Over 81% have received two shots or more, public health data shows.

Earlier in the day, the country’s health authorities backtracked on a highly controversial decision to stop testing fully vaccinated people who showed symptoms of Covid. The recommendation was rolled out in October, leading to a 35% decline in Covid-19 tests taken.

“The Public Health Agency has decided to recommend that the regions offer testing to everyone who is 6 years and older who gets symptoms that may be COVID-19,” the health authority said in a statement.

Sweden bucked the trend among European governments in its approach to handling the pandemic, electing not to impose widespread lockdowns. Having relied primarily on voluntary measures and social distancing, the country displayed several times higher death rates per capita than its Nordic neighbors, though it still fared better than many European countries, registering some 1.18 million cases and just over 15,000 coronavirus deaths since the beginning of the pandemic.

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