Scientists have used artificial intelligence to “predict” formulas for new designer drugs, with the stated goal of helping to improve their regulation. The AI generated formulas for nearly nine million potential new drugs.

Researchers with the University of British Columbia (UBC) used a deep neural net for the job, teaching it to make up chemical structures of potential new drugs. According to their study, released this week, the computer intelligence fared better at the task than the scientists had expected.

The research team used a database of known designer drugs – synthetic psychoactive substances – to train the AI on their structures. The market for designer drugs is ever-changing, since their manufacturers are constantly tweaking their formulas to circumvent restrictions and produce new “legal” substances, while cracking their structure takes months for law enforcement agencies, the researchers said.

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“The vast majority of these designer drugs have never been tested in humans and are completely unregulated. They are a major public-health concern to emergency departments across the world,” one of the researchers, UBC medical student Dr. Michael Skinnider has said.

After its training, the AI was able to generate some 8.9 million potential designer drugs. Afterwards, researchers ran a data sheet of some 196 new drugs, which had emerged in real life after the model was trained, and found that more than 90% of these have been already predicted by the computer.

“The fact that we can predict what designer drugs are likely to emerge on the market before they actually appear is a bit like the 2002 sci-fi movie, Minority Report, where foreknowledge about criminal activities about to take place helped significantly reduce crime in a future world,” senior author Dr. David Wishart, a professor of computing science at the University of Alberta, has said.

Identifying completely unknown substances remains an issue for the AI, the research team has noted, but they hope it might potentially help with that task, since the computer was also able to predict which formulas of designer drugs were more likely to be created and hit the market. The model “ranked the correct chemical structure of an unidentified designer drug among the top 10 candidates 72 percent of the time,” while throwing in spectrometry analysis, which is an easily obtained measurement, bumped the accuracy to some 86%.

“It was shocking to us that the model performed this well, because elucidating entire chemical structures from just an accurate mass measurement is generally thought to be an unsolvable problem,” Skinnider stated.

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Czechia will prohibit people who have not been vaccinated from entering public spaces such as restaurants and shops from Monday. Negative Covid-19 tests will no longer be allowed.

Speaking on Wednesday, outgoing Prime Minister Andrej Babis said the country would adopt the so-called Bavarian model from Monday next week, prohibiting those who have not received a Covid-19 vaccine from entering public places. Those who have recently recovered from the virus will be allowed entry. 

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The country will enter a partial lockdown of the unvaccinated from Monday morning, assuming the restrictions are approved by the cabinet on Thursday.   

“We will introduce the Bavarian model from Sunday to Monday. This means that entry to restaurants, service establishments, or mass events will only be allowed for vaccinated or survivors. Those vaccinated with a single dose must have a PCR test,” Babis said on local TV.

The prime minister said that self-testing would be completely cancelled, as he lamented unvaccinated people for clogging up hospitals and preventing treatment reaching those with other illnesses.  

“The death toll is rising; the situation is serious. Vaccination is the only solution, there is no other,” he added. 

The country is seeing a spike in infections, with a record 22,479 new cases reported on Tuesday. 

The Bavarian model refers to strict anti-Covid measures introduced in the southern German state. Markus Soder, the state’s premier, claimed there was no choice but to implement “a kind of lockdown for the unvaccinated,” citing increasing pressure on hospitals and medical staff. 

Meanwhile, some two million people in Austria who are yet to receive their Covid shots have been subject to the world’s first lockdown for the unvaccinated, in an effort to bring case numbers down.  

While 68% of people are vaccinated in Germany, and 65% in Austria, just over 60% are vaccinated in the Czech Republic. 

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A pack of wild boars were rounded up and euthanized after one of the animals attacked a police officer in the streets of Hong Kong – the opening shot in a pitched battle between the feral hogs and the city’s law enforcement.

A group of veterinarians took seven wild boars into custody, euthanizing the beasts after knocking them out with dart guns in an area near the financial center of the city, according to a statement from Hong Kong’s Agriculture, Fisheries, and Conservation Department on Thursday.

The pigs were captured after one attacked a police officer last week, an act which reflects the city’s new policy toward the animals: stop them before they attack again.

The aggressive boar knocked down a police officer by biting his leg last week as the two faced off in a residential car park, the pig only losing the battle after falling off the building to its death. The wild boars are apparently “accustomed” to wandering back and forth along the roadway, begging for food from pedestrians and vehicles alike. Previously, the city had handled the population by capturing and sedating the animals, then relocating them to “remote areas,” according to the the department.

Hong Kong CEO Carrie Lam vowed to increase penalties for those citizens found feeding the boars, which have reportedly been responsible for some 30 attacks in recent years. While residents are warned not to feed the boars so as not to encourage population growth or disease outbreaks, the animals are a favorite among some visitors. Still, Lam insisted “we can’t simply sit on our hands while things deteriorate.”

Animal rights groups have responded with a protest letter against a policy of euthanasia, pointing out that most visitors do not feed the boars and arguing resources should be directed toward stopping the human activity rather than blaming all the boars. Allowing the boars to be captured and killed “ignores their right to live and considers their existence in urban areas as a capital offense,” the letter read.

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General Joseph L. Votel (Ret.) joined BENS as CEO & President in January 2020 following a 39-year military career where he commanded special operations and conventional forces at every level; last serving as the Commander of U.S. Central Command (CENTCOM) where he was responsible for U.S. and coalition military operations in the Middle East, Levant, and Central and South Asia. General Votel’s career included combat in Panama, Afghanistan, and Iraq and he led the 79-member coalition that successfully liberated Iraq and Syria from the Islamic State Caliphate. General Votel preceded his assignment at CENTCOM with service as the Commander of U.S. Special Operations Command and the Joint Special Operations Command.

The Cipher Brief:  Did you ever envision that the U.S. would pull out so quickly or completely leaving the Afghan military on its own without U.S. air support?  

General Votel: I did not anticipate this during my time – but once the President sets a hard departure date – then a fast withdrawal is inevitable.  No Commander wants to accept unnecessary risk with troops on the ground when you are up against a clearly articulated departure date.

The Cipher Brief: Intelligence assessments wildly missed the mark on how fast Kabul would fall, what factors contributed most directly to this? 

General Votel: Certainly, the departure of our own capabilities is a big part of this; the lack of direct contact with Afghan leaders is another important factor; and, of course, once it was clear that we were departing (and took our Commander out) — we lost priority and access with our normal and reliable Afghan intelligence sources.

The Cipher Brief: U.S. personnel are facing a deteriorating security situation at the Kabul airport while U.S. forces are still deploying for the contingency operation, another sign that the administration underestimated how fast the Taliban would reach Kabul. The U.S. could have chosen to slow the Taliban advance using airpower, why didn’t it happen, do you think? 


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General Votel: I think it is very clear that this was no longer a priority for our Government.  The mission right now, at least articulated over the weekend, is about supporting evacuation of the diplomats and helping with the departure of those Afghans who assisted the US and meet the criteria for evacuation.  While I don’t know this for certain — I believe what we were trying to do with over the horizon air support in a rapidly developing situation, was not optimal or overly effective.  It doesn’t seem to have done much – if anything.

The Cipher Brief: The U.S. has allowed U.S. supplied military hardware, weapons and technology to fall into the hands of the Taliban, a group responsible for the deaths of U.S. personnel and thousands of innocent Afghans.  The U.S. government holds private citizens and corporations accountable for far lesser violations of export violations involving dual-use technology or military equipment, etc.  How should Americans think about this situation now, where the Taliban will use equipment, paid for the by the U.S. taxpayer, to potentially perpetrate acts of violence against U.S. interests, and erode democratic values that the U.S. tried to introduce to Afghanistan?  

General Votel: Not sure on this.  Unfortunately, it is not the first time we have seen this — remember ISIS in 2014, in Mosul?  I suspect these will be more trophy pieces than they will be hard military capability – with the exception of small arms, mortars, and artillery.  Most of this will be difficult for the Taliban to sustain – and they probably prefer their own gear, anyway.

The Cipher Brief:  There is a lot of anger among the national security community right now.  What would you say to individuals who have suffered because of the U.S. role in Afghanistan, who may be feeling anger and rage?  

General Votel: I can’t really comment on anger in the national security community — I am sure that exists, but the sentiment that seems more strong to me, is disappointment.  No one wants what we are seeing now.  I think most security professionals can accept a decision to depart by the Commander in Chief — that is well within his authority, and everyone understands this; what is harder to accept is the manner in which this happened, and how it has played out.  It was hard for me to watch Taliban sitting at a conference table that I once sat at with the Afghan President.  In a number of public engagements, I have participated in lately – people have asked me if this whole effort was a waste.  My response has been consistent.  American military personnel, members of the IC and the diplomatic corps conducted themselves honorably throughout this war.  They responded when the Nation called and did their best for our Country, each other, and the Afghan people.  There will be plenty of time to place the blame – but the vast, vast majority of Americans who participated in some aspect of the Afghan War did so nobly and to the best of their ability.  We should not lose sight of this.  That this did not turn out the way we all hoped — is not their fault … and I would not want anyone (especially families of our wounded and killed) to think these efforts were in vain.  That is not how I thought about them at the time, and it is not how I think about them now.  They answered when the Nation called.

Have a perspective to share?  Email Editor@thecipherbrief.com

Read more expert-driven national security insight, perspective and analysis in The Cipher Brief

 

 

The post The Painful Lessons of Afghanistan appeared first on The Cipher Brief.

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General Joseph L. Votel (Ret.) joined BENS as CEO & President in January 2020 following a 39-year military career where he commanded special operations and conventional forces at every level; last serving as the Commander of U.S. Central Command (CENTCOM) where he was responsible for U.S. and coalition military operations in the Middle East, Levant, and Central and South Asia. General Votel’s career included combat in Panama, Afghanistan, and Iraq and he led the 79-member coalition that successfully liberated Iraq and Syria from the Islamic State Caliphate. General Votel preceded his assignment at CENTCOM with service as the Commander of U.S. Special Operations Command and the Joint Special Operations Command.

The Cipher Brief:  Did you ever envision that the U.S. would pull out so quickly or completely leaving the Afghan military on its own without U.S. air support?  

General Votel: I did not anticipate this during my time – but once the President sets a hard departure date – then a fast withdrawal is inevitable.  No Commander wants to accept unnecessary risk with troops on the ground when you are up against a clearly articulated departure date.

The Cipher Brief: Intelligence assessments wildly missed the mark on how fast Kabul would fall, what factors contributed most directly to this? 

General Votel: Certainly, the departure of our own capabilities is a big part of this; the lack of direct contact with Afghan leaders is another important factor; and, of course, once it was clear that we were departing (and took our Commander out) — we lost priority and access with our normal and reliable Afghan intelligence sources.

The Cipher Brief: U.S. personnel are facing a deteriorating security situation at the Kabul airport while U.S. forces are still deploying for the contingency operation, another sign that the administration underestimated how fast the Taliban would reach Kabul. The U.S. could have chosen to slow the Taliban advance using airpower, why didn’t it happen, do you think? 


The Cipher Brief hosts private briefings with the world’s most experienced national and global security experts.  Become a member today.


General Votel: I think it is very clear that this was no longer a priority for our Government.  The mission right now, at least articulated over the weekend, is about supporting evacuation of the diplomats and helping with the departure of those Afghans who assisted the US and meet the criteria for evacuation.  While I don’t know this for certain — I believe what we were trying to do with over the horizon air support in a rapidly developing situation, was not optimal or overly effective.  It doesn’t seem to have done much – if anything.

The Cipher Brief: The U.S. has allowed U.S. supplied military hardware, weapons and technology to fall into the hands of the Taliban, a group responsible for the deaths of U.S. personnel and thousands of innocent Afghans.  The U.S. government holds private citizens and corporations accountable for far lesser violations of export violations involving dual-use technology or military equipment, etc.  How should Americans think about this situation now, where the Taliban will use equipment, paid for the by the U.S. taxpayer, to potentially perpetrate acts of violence against U.S. interests, and erode democratic values that the U.S. tried to introduce to Afghanistan?  

General Votel: Not sure on this.  Unfortunately, it is not the first time we have seen this — remember ISIS in 2014, in Mosul?  I suspect these will be more trophy pieces than they will be hard military capability – with the exception of small arms, mortars, and artillery.  Most of this will be difficult for the Taliban to sustain – and they probably prefer their own gear, anyway.

The Cipher Brief:  There is a lot of anger among the national security community right now.  What would you say to individuals who have suffered because of the U.S. role in Afghanistan, who may be feeling anger and rage?  

General Votel: I can’t really comment on anger in the national security community — I am sure that exists, but the sentiment that seems more strong to me, is disappointment.  No one wants what we are seeing now.  I think most security professionals can accept a decision to depart by the Commander in Chief — that is well within his authority, and everyone understands this; what is harder to accept is the manner in which this happened, and how it has played out.  It was hard for me to watch Taliban sitting at a conference table that I once sat at with the Afghan President.  In a number of public engagements, I have participated in lately – people have asked me if this whole effort was a waste.  My response has been consistent.  American military personnel, members of the IC and the diplomatic corps conducted themselves honorably throughout this war.  They responded when the Nation called and did their best for our Country, each other, and the Afghan people.  There will be plenty of time to place the blame – but the vast, vast majority of Americans who participated in some aspect of the Afghan War did so nobly and to the best of their ability.  We should not lose sight of this.  That this did not turn out the way we all hoped — is not their fault … and I would not want anyone (especially families of our wounded and killed) to think these efforts were in vain.  That is not how I thought about them at the time, and it is not how I think about them now.  They answered when the Nation called.

Have a perspective to share?  Email Editor@thecipherbrief.com

Read more expert-driven national security insight, perspective and analysis in The Cipher Brief

 

 

The post The Painful Lessons of Afghanistan appeared first on The Cipher Brief.

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Those making and knowingly using fake vaccination certificates in Germany could soon face up to five years behind bars, as the country’s likely future coalition government is looking to tighten the screws.

Coming under the same category are also fake test results and Covid recovery certificates, with similar penalties for the counterfeiters and the holders. Everything envisaged in the new guidelines was drafted by the Social Democrats, along with the Free Democratic and Green Parties. The three are currently in coalition talks and expected to form a new government as early as next week.

The German Parliament will decide on the regulations this Thursday, though a draft has already been seen by the media outlet DPA.

According to German media, the manufacturing and sale of fake certificates has become a booming black-market industry in the country. In just one such case reported by Der Spiegel in late October, a counterfeiter working at a pharmacy in Munich and her accomplice had churned out more than 500 fake digital certificates in the span of one month, raking in €350 for each one sold.

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Felix Gottwald has spoken out as police patrol the streets of Austria to check people are vaccinated © Lisi Niesner / Reuters | © Instagram / felixgottwaldofficial
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Meanwhile, Berlin authorities are planning to further ramp up restrictions in the city, where, starting Monday, having either a vaccination or recovery certificate is a must to enter restaurants, cinemas, theaters, museums, galleries, swimming pools, gyms, as well as hairdressers and beauty salons. On Tuesday, Berlin Mayor Michael Müller confirmed that authorities want to “have an additional instrument” to contain the spread of the virus. However, he declined to elaborate on what the new measures will be. Local media speculate that starting next week, in addition to the requirement to have a vaccination or recovery certificate to enter public places, people inside the venues will also need to practice social distancing and wear a mask, or have a recent negative test result.

This comes after Covid-19 numbers in Berlin hit an all-time high last Thursday, with 2,874 new cases reported that day.

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Reuters has apologized for its poor choice of photo to illustrate a story about a monkey brain study that was deemed offensive and racist in China.

On Thursday, Reuters published a story titled “Monkey-brain study with link to China’s military roils top European university.” The report was about a Chinese professor studying how a monkey’s brain functions at extreme altitude.

The study was done with the help of Beijing’s People’s Liberation Army (PLA) with the aim of developing new drugs to prevent brain damage, Reuters said.

The news agency promoted the story on Twitter with a photo of smiling Chinese soldiers in an oxygen chamber.

The tweet prompted outrage in China, with people calling it racist on social media. Reuters responded on Friday night by deleting the original tweet because the photo of Chinese soldiers was unrelated to the story and “could have been read as offensive.”

“As soon as we became aware of our mistake, the tweet was deleted and corrected, and we apologize for the offense it caused,” Reuters said in a statement to the Global Times, China’s state-run newspaper.

It was not the first time the leading Western news agency had run into trouble in China. In July, the Chinese Embassy in Sri Lanka criticized Reuters for using a photo of Chinese weightlifter and Tokyo 2020 Olympics gold medalist Hou Zhihui that the country’s state media described as “ugly” and “disrespectful to the athlete.”

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The French government has kicked off a €14 million national campaign to tackle underage prostitution and pimping. It comes months after a report found as many as 10,000 youngsters, mostly teen girls, are involved in the sex trade.

The campaign, launched by the Ministry for Solidarity and Health on Monday, is expected to be fully rolled out in 2022. The ministry described the problem as a “growing phenomenon that society can no longer ignore” and about which “too little is known.”

The government programme is expected to “increase awareness” while helping to “inform and provide a better understanding of the phenomenon.” It also aims to help “identify the young people involved” and “prosecute clients and pimps more effectively.”

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According to RFI, the prevalence of underage prostitution has increased by as much as 70% over the past five years, with social media believed to be compounding the problem. The public broadcaster noted that the situation had worsened during the Covid-19 pandemic when young people spent more time online.

In July, a working group produced a damning report that found between 7,000 and 10,000 young people were involved in prostitution across the country. The majority are young girls aged between 15 and 17, but a ministry statement noted that the “entry point” into prostitution was increasingly becoming younger at around 14-15 years.

“There’s really a normalisation of prostitution of young people because girls say that selling sex is a way of making lots of money easily and that it can help them reach their dream life,” deputy public prosecutor Raphaelle Wach told the news outlet France 24.

In its statement, the ministry noted that many minors did not consider themselves victims and valued the “financial autonomy” and feelings of “belonging to a group” and “regaining control” over their lives.

“These minors are however in danger, both physically and psychologically,” the ministry warned.

“Covid played a considerable role because social networking provided new ways of being able to hook in underage girls very easily,” Geneviève Collas, who runs an NGO fighting human trafficking, told RFI. She added that recruiting minors has been made “easier” with short-term apartment rental apps like Airbnb helping mask the scale of the problem on the streets.

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Greece will soon prohibit unvaccinated residents from entering a litany of public spaces, the country’s prime minister has announced, claiming its current Covid outbreak is largely fueled by those who haven’t received the jab.

Starting next week, the unvaccinated will be barred from entry to restaurants, cafes, theaters, bars, gyms and museums, among other indoor public places, PM Kyriakos Mitsotakis said on Thursday, noting that a negative Covid-19 test will no longer be accepted as an alternative to proof of vaccination.

“This is indeed a pandemic of the unvaccinated,” he said as he announced the move in a televised address, adding “Greece is mourning unnecessary losses because it simply does not have the vaccination rates of other European countries.”

The new rules are set to take effect on Monday, and will require Greeks to present vaccine certificates to businesses and other indoor establishments to be allowed inside. Those attending religious services mark a rare exception, however, as they will only be asked to present a negative test in order to enter a church or other place of worship.

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People wait in front of a vaccination after Austria's government has imposed a lockdown on people who are not fully vaccinated, in Vienna, Austria, November 18, 2021. © Reuters /Leonhard Foeger
Austria may lock down the vaccinated too

In a bid to encourage booster vaccinations among the elderly – a population much more vulnerable to Covid-19 – citizens over the age of 60 will be made to renew their certificate after a period of seven months.

While officials had hoped to hit a full vaccination figure of 70% for Greece’s population of 11 million by autumn, the number currently stands at about 62%, according to Reuters. As its weekly case counts continue to soar to record highs, the country reported 7,317 new Covid-19 infections and 63 deaths on Thursday, bringing the totals to more than 860,000 cases and some 17,000 fatalities since the pandemic kicked off in late 2019.

The new restrictions in Greece mirror similar policies implemented elsewhere in Europe, with Austria, Germany, Italy, France, the Czech Republic and Slovakia each imposing limits on public life for the unvaccinated. Though the Austrian government recently imposed a full lockdown for millions of residents who have not received the shot, some officials in that country are pushing for even harsher policies, including a national stay-at-home order on the jabbed and non-jabbed alike.

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