With about 2.3 million people already suffering with serious water, food and pasture shortages in Somalia, a rapidly worsening drought could lead to an “extreme situation” by April next year.
As infections are rising again, scientists all around the world are rushing to fight the danger, offering a choice of new treatments and unusual variants of vaccines.
Levels of contagion are setting new records, hospitals are overwhelmed, governments are starting to introduce lockdowns, and not only for unvaccinated people – the picture of the fight against Covid-19 looks quite disappointing. However, there’s still a place for good news: Research teams report positive results while trialling new medicines and vaccine types.
Nasal vaccines
Vaccination will remain one of the most effective tools against Covid-19. As Professor David Dockrell, from the Center for Inflammation Research of the University of Edinburgh, told RT, “vaccines will continue to be a central part of how we control the virus.”
“If we can dampen down the number of infections, and the severity of infections, and also the extent to which the virus can replicate in people when they become infected, then we are slowing down the ability of the virus to change and to mutate,” he explains.
So I think the vaccines still will be a very important part of the preventive strategy. It’s vital that they are available to all the world’s population, irrespective of where people live, and the wealth of the country in which they live.
However, vaccination doesn’t always mean you have to get an injection. For instance, several intranasal Covid-19 vaccines are currently being developed. As the virus gets into the body through the nose, a nasal spray or drops are aimed to produce mucosal immune response and prevent it from getting into the lungs.
In India, a vaccine of this type is already completing Phase 2 of clinical trials. In Russia, a nasal vaccine is undergoing a clinical trial on volunteers. In Thailand, a home-developed product is expected to be trialed on humans next spring. In the US, Universities of Houston and Stanford recently reported good results of their experiments carried out on mice.
Intranasal vaccines can have several potential benefits compared to inoculation.
“They would be easier to use, because they can be self-administered. They wouldn’t need a nurse or clinical settings,” Swedish professor emeritus of epidemiology Marcello Ferrada de Noli explained to RT. As a result, he says, there’s hope that fewer people will be reluctant to be immunized. Not so many of us find it pleasant to get a jab – and after all, there are those who are just afraid of needles. Also, it would be much easier to vaccinate children with nasal substances.
However, what concerns Prof. de Noli the most is the duration of the effect of a vaccine of this type. Still, scientists can’t say for sure whether a nasal substance may completely replace a shot. According to Alexander Gintsburg, the head of Moscow’s Gamaleya Center biomedical research institute, which created the Sputnik V vaccine, the nasal version they are working on would serve for an additional protection against the virus, but would not replace the injections.
Chew the virus away?
A nasal vaccine is not the only one being developed. In summer, it was revealed that Russian Defense Ministry scientists were creating a ‘chewing gum’ vaccine, also targeting the mucosal immune response. Meanwhile, a UK firm announced this month that it would conduct a human trial of a skin patch that uses T-cells to confront the virus. Developers hope it would offer longer-lasting immunity than the existing vaccines. Work on a similar project is being done in the University of Queensland, Australia.
While it all looks so promising, Prof. de Noli warns that it would still take a lot of time until these products become available to the public. “I think that discoveries in this field are a very good thing. But if we say ‘We discovered a new type of vaccine’, people will say ‘Aha, so I’m going to wait’. But we need to vaccinate people now,” he points out.
Improving Covid treatment
Vaccines are not a silver bullet, unfortunately, given the not-so-high level of global immunization and the constantly emerging new strains of the virus. “People might get infected despite having had a vaccine, but I still think the vaccine strategy is going to be central to how we manage this kind of virus going forward,” Prof. Dockrell says. “But we will have other strategies that will be very important. We will have other elements. When we put them all together, it gives us the best opportunity that people can live with coronaviruses, and hopefully, the mortality can be limited to much lower extense than what we’ve sadly seen in the last eighteen months.”
Monoclonal antibodies will be central to the ongoing vaccine strategy, Prof. Dockrell explains. These are the antibodies similar to those the body uses to fight the virus. They are produced in labs and given via infusion or injection to boost the patient’s response against certain diseases. Monoclonal antibody treatment is used for people under a high risk of developing severe infection (including older patients 65+ years old or those with chronic medical conditions). It’s already being used in the US, following last year’s FDA approval. Earlier in November, the European Medicines agency recommended authorizing two monoclonal antibody medicines.
In October, UK’s AstraZeneca reported positive results of a Phase 3 study of its antibody combination, which, according to developers, is highly effective in both prevention and treatment of coronavirus.
Researchers are also working on a possibility to save Covid-infected patients from the so-called ‘cytokine storm’ – a situation when the immune system reacts so intensely that kills not only the virus, but the whole organism itself. A drug to ‘calm the storm’ was registered in Russia this year, and it’s already being used on patients.
Another way to fight Covid-19 is to use antiviral drugs. When the pandemic started, medics had to use something already existing (like anti-influenza Favipiravir) or something being authorized for emergency use (like remdesivir). Now, more than a year on, the work to create a special drug to specifically cure Covid-19 is giving its results. This month, Russia registered its first injectable anti-Covid medicine. A bit earlier, the UK became the first country to approve an antiviral pill produced by the US-based companies Merck and Ridgeback Biotherapeutics. Another American firm, Pfizer, got positive results from trials of its drug of the same kind. Both firms hope that with a drug in the form of a pill it would be easier to treat people at home.
Appreciating all the efforts on the field of developing anti-Covid treatment, Prof. de Noli points out that still, the key issue now is to reduce the spreading of the virus. “The new medicines are developed for people who already got the disease,” he says.
But we need to prevent people from getting the infection, not let them get infected because we have some new medicine that can cure them.
The same idea is echoed by scientists all over the world quoted in plenty of articles dedicated to the medical gains: it’s great to have the treatment, but none of the drugs may substitute vaccination, as first and foremost, humanity has to adopt preventive measures and stop the pandemic.
A large settlement of migrants in the suburbs of Dunkirk in northern France has been dismantled, in the wake of yet another wave of tensions with the UK over the growing number of illegal crossings.
“At my instruction, the security forces are evacuating the illegal migrant camp in Grande-Synthe this morning,” French Interior Minister Gerald Darmanin said on Twitter on Tuesday. He added that state services in the region would provide shelter for the group.
Government spokesman Gabriel Attal said the decision to dismantle the camp was primarily based on the intention to put people into shelters ahead of the winter season.
Around 1,500 migrants were evacuated from the site via buses and their tents removed. According to Utopia 56, one of the charities monitoring the process of dismantling the camp, people “were forced to board buses, without being informed of their destination, and some of their personal belongings have been destroyed.”
Évacuation forcée et sans annonce du campement de Grande-Synthe depuis ce matin : plus de 500 personnes sont contraintes de monter dans des bus, sans être informées de leur destination : “police ou hôtel”. Une partie de leurs effets personnels est en cours de destruction. pic.twitter.com/EwFPR2yl2j
Tides changing on Channel crossings? French police began moving some 1,500 migrants on from a camp near Dunkirk amid talks yesterday between Priti Patel and her French counterpart agreeing to stop ‘100 percent’ of Channel crossings after record numbers reached the UK in 2021. pic.twitter.com/PUE9YDCTAY
In a separate tweet, Darmanin announced the arrest of 13 alleged migrant smugglers, “bringing the total to 1,308 since January.”
“These smugglers are criminals who exploit human misery, responsible for irregular immigration,” the minister wrote.
Tuesday’s actions by French authorities came in the wake of a phone call between Darmanin and his British counterpart Priti Patel. The two discussed the increasing number of illegal migrants attempting to cross the English Channel, and reiterated the importance of cooperation in making this route “unviable,” Patel said afterwards.
At Grande-Synthe, near Dunkirk, where demolition work has already begun on the migrant camp. Around 1,500 people, many of them Iraqi Kurds, have been moved out of the site@SkyNewspic.twitter.com/rHFDHHcxmf
The UK and France have a history of mutual accusations when it comes to illegal migration. While British officials have claimed that French authorities do not do enough to prevent migrants from embarking for the dangerous trip, France’s government has said that the UK should reform its labor market rules in order to become less attractive to migrants.
More than 23,000 people have crossed the Channel by boat this year, compared to 8,404 in 2020, according to Press Association figures.
Covid-battered global supply chains are being threatened by organized criminals, including drug cartels and con artists posing as legit suppliers, a new study has found, warning that the situation is set to get worse.
The international supply chain woes amid the Covid-19 pandemic are highlighted in a new annual report, released this week by the British Standards Institution (BSI).
The document, titled the ‘Supply Chain Risk Insights Report’, highlights Covid’s impact on supply chains, with the experts also warning that organized crime has increasingly preyed on this crucial area during the pandemic. On multiple instances, criminals were posing as legitimate logistics providers, stealing goods during shipment.
“I’m seeing a significant number of false suppliers acting as genuine potential suppliers in supply chain logistics provision – warehousing distribution, distribution centres, transportation companies – and actually, they are criminal groups trying to infiltrate the logistics supply chain,” said David Fairnie, BSI’s principal consultant in supply chain security. He urged producers to “continuously monitor” the supply chain and to not immediately trust new logistics providers – especially those contacted only remotely.
So, arguably today more than ever, you do need to know your suppliers. So far in 2021, BSI has noted this issue of fake carriers in an increasing number of countries in both the Americas and Europe.
Criminals have apparently been trying to steal goods in various ways, with phony truck drivers loading up items and taking off with them, while conmen “posing as legitimate employees” have reportedly been observed lurking around delivery destinations to steal cargo.
At the same time, the report found that trade in illicit goods has also been on the rise lately, with the illegal drug industry in particular appearing to flourish. While the supply chain for drug cartels, which require large amounts of assorted chemicals to produce narcotics, was disrupted due to the pandemic lockdowns and border closures impacted trafficking routes, organized crime quickly overcame these problems, the BSI noted.
“Drug cartels around the world did not miss a beat,” Chris Tomas, BSI lead intelligence analyst, said.
While many cartels shifted their production towards synthetic drugs, namely amphetamine, amid the pandemic, the apparent “lack of eradication of coca crops in Latin American countries” also remains an issue, the BSI said. The flow of cocaine has grown over the past year and is expected to increase even further, the organization warned.
“The numbers and quantities of cocaine seizures in Europe increased steadily in 2020 and 2021 and are expected to continue to rise in 2022,” the report reads.
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Austria will introduce a full lockdown that could last for three weeks on Monday in an attempt to tackle a new wave of Covid-19 infections. The government has also ordered the entire population to get vaccinated from February 1.
On Friday, conservative Chancellor Alexander Schallenberg told a news conference that a complete lockdown of the nation would begin on Monday and last for an initial 10 days.
He stated that the restrictions could be extended if infection rates did not start to fall, but he insisted the lockdown would not exceed 20 days.
The measures concern the entire Austrian population. The government has already imposed a partial lockdown on the unvaccinated in an effort to reduce hospitalization rates amid a surge in Covid-19 cases.
When the full lockdown ends, restrictions will remain in place for the unvaccinated.
Schallenberg’s announcement came after a meeting of nine state governors, two of whom had already vowed to introduce full lockdowns in their regions on Monday, in the western province of Tyrol.
The chancellor also announced that vaccinations would be mandatory from February 1. “We haven’t been able to convince enough people to vaccinate. For too long, I and others have assumed that you can convince people to get vaccinated,” he added, giving his rationale for the mandate.
Schallenberg said he lamented the political forces, radical opposition, and fake news fighting against vaccination.
Austria has one of the lowest vaccination rates in western Europe, with only 65% inoculated against the deadly virus according to data from Johns Hopkins university.
Infection rates are almost among the highest on the continent. The seven-day incidence rate stands at 971.5 per 100,000 people.
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A Canadian teenager has been arrested after allegedly stealing $36.5 million in cryptocurrency from a person in the US. The police claim it was the largest such heist involving one victim ever registered in North America.
Police in the city of Hamilton, Ontario, arrested the unidentified perpetrator on Wednesday, after over a year investigating what they have described as the biggest-ever cryptocurrency theft from a single person in either the US or Canada. Local police began a joint investigation with the Federal Bureau of Investigation and the US Secret Service Electronic Crimes Task Force in March 2020, when the theft was reported.
The Hamilton Police Service said it had made “multiple” seizures in excess of CA$7 million (US$5.5 million) during the arrest, which came after investigators noticed some of the stolen money had been used to buy an online username considered “rare” in the gaming community, according to a police statement.
The victim was apparently targeted by a cell phone hijack known as SIM swapping. This method involves manipulating cellular network employees to duplicate phone numbers in order to let the scammer intercept the two-factor authorization requests that allow them access to a victim’s account.
This method is considered especially potent because a lot of people use the same password for multiple sites, according to Detective Constable Kenneth Kirkpatrick, of the Hamilton Police’s cybercrimes unit. He added that cyber and cryptocurrency crimes were becoming increasingly common, but noted that the figures involved in this case were “very surprising.”
“It’s a large amount of money in anybody’s opinion,” Kirkpatrick said, adding that the case was currently in the Hamilton court system.
The police haven’t revealed the age or gender of the youth, the username they purchased, or whether they were acting alone.
A cleaner for Israel’s defense minister has been accused of espionage after allegedly offering to place malware on his boss’ household computer for an Iran-linked hacking group.
In a statement on Thursday, the Shin Bet security service said that Omri Goren, a housekeeper for Defense Minister Benny Gantz, and a former bank robber according to Israeli media, corresponded with an unnamed person over social media shortly before his arrest.
Goren reached out earlier this month to “a figure affiliated with Iran and offered to help him in different ways, in light of his access to the minister’s home,” the statement read, according to the Times of Israel.
It is understood that Goren offered to spy and place malware on Gantz’s computer on behalf of a hacking group, reportedly called ‘Black Shadow’ and associated with Iran, Tel Aviv’s perennial enemy. It is also said that he provided photos of Gantz’s residence to prove he had access.
A Central District prosecutor filed espionage charges against Goren on Thursday. If convicted, the accused could face a sentence of between 10 and 15 years, according to the Times of Israel.
The 37-year-old Lod resident has previously served four prison sentences, the most recent of which was for four years. Goren was found guilty of five crimes between 2002 to 2013, two of the convictions were for bank robbery.
The Shin Bet said they would review their processes for staff background checks “with the goal of limiting the possibility of cases like this repeating themselves in the future.”
Speaking on Kan public radio, Gal Wolf, the attorney representing Goren, suggested his client had intended to extract money from the Iranians without carrying out any spying.
Japan’s fifth wave of Covid-19 has virtually disappeared so dramatically that some scientists are puzzled as to why it happened. One team suggests the highly infectious Delta strain mutated into extinction on the island nation.
In mid-August, Japan experienced a peak in Covid-19 infections, recording over 23,000 new cases per day. Now the metric is just around 170, with deaths attributed to the disease mostly remaining in single digits this month.
The decline has been attributed by many to high vaccination rates, public acceptance of masks, and other factors, but some researchers say the drop was uniquely significant, compared to other nations with similar conditions.
Ituro Inoue, a geneticist at the National Institute of Genetics, believes that Japan had the good fortune of witnessing the Delta strain mostly rooting out other variants of the SARS-CoV-2 virus before then eradicating itself. He explained his team’s theory to the Japan Times newspaper this week.
For some time now, Inoue and his fellow scientists were researching mutations of SARS-CoV-2 and how they are affected by the protein nsp14, which is crucial for the reproduction of the virus.
RNA viruses, like the one causing Covid-19, tend to have a very high mutation rate, which helps them quickly adapt to changes in the environment. However, this opens the door for a so-called “error catastrophe,” when bad mutations pile up and finally cause the full extinction of a strain. The protein nsp14 appears to offer a form of error proofreading that helps the virus genome to stay below the threshold of the “error catastrophe.”
In the case of Japan’s fifth wave of Covid-19, the Delta variant’s nsp14 failed at this job, Inoue believes, based on the genetic study of specimens collected from June to October. Contrary to his team’s expectations, there was a lack of genetic diversity, while many samples had many genetic changes in the site called A394V, which is linked to the error-fixing protein.
“We were literally shocked to see the findings,” the researcher told the Japan Times. “The Delta variant in Japan was highly transmissible and [was] keeping other variants out. But as the mutations piled up, we believe it eventually became a faulty virus and it was unable to make copies of itself.”
The theory could be relevant to the previous SARS strain, which was identified in 2003, explaining why it didn’t cause a pandemic. But that would be hard to confirm, since the outbreak ended relatively quickly and didn’t result in the massive collection of genetic data necessary to test the hypothesis.
It’s not clear why Japan had this lucky turn of events, but nothing comparable happened in other East Asian countries like South Korea, where populations are genetically close to that of Japan. Virus mutations similar to those flagged by the scientists have been discovered in at least 24 countries, Inoue said. He and his team plan to publish a paper detailing their findings by the end of November.
Even if the natural extinction theory is confirmed, it is at best a temporary reprieve for the Japanese people. New, more successful strains are likely to eventually find their way into the country, though quarantine measures and immigration control could delay the emergence of new variants in Japan, Inoue believes.
Meanwhile, Tokyo is bracing for a new wave of Covid-19 this winter and is preparing to live with the virus. The government reportedly plans to ease travel restrictions by increasing the number of people it allows to enter the country per day from 3,500 to 5,000.
Despite COVID-19 lockdowns and restrictions, some 650,000 women and girls were provided with gender-based violence services through a joint UN and European Union (EU) programme working to stamp out what is arguably one of the most prevalent human rights violations.
