As infections are rising again, scientists all around the world are rushing to fight the danger, offering a choice of new treatments and unusual variants of vaccines.
Levels of contagion are setting new records, hospitals are overwhelmed, governments are starting to introduce lockdowns, and not only for unvaccinated people – the picture of the fight against Covid-19 looks quite disappointing. However, there’s still a place for good news: Research teams report positive results while trialling new medicines and vaccine types.
Nasal vaccines
Vaccination will remain one of the most effective tools against Covid-19. As Professor David Dockrell, from the Center for Inflammation Research of the University of Edinburgh, told RT, “vaccines will continue to be a central part of how we control the virus.”
“If we can dampen down the number of infections, and the severity of infections, and also the extent to which the virus can replicate in people when they become infected, then we are slowing down the ability of the virus to change and to mutate,” he explains.
So I think the vaccines still will be a very important part of the preventive strategy. It’s vital that they are available to all the world’s population, irrespective of where people live, and the wealth of the country in which they live.
However, vaccination doesn’t always mean you have to get an injection. For instance, several intranasal Covid-19 vaccines are currently being developed. As the virus gets into the body through the nose, a nasal spray or drops are aimed to produce mucosal immune response and prevent it from getting into the lungs.
In India, a vaccine of this type is already completing Phase 2 of clinical trials. In Russia, a nasal vaccine is undergoing a clinical trial on volunteers. In Thailand, a home-developed product is expected to be trialed on humans next spring. In the US, Universities of Houston and Stanford recently reported good results of their experiments carried out on mice.
Intranasal vaccines can have several potential benefits compared to inoculation.
“They would be easier to use, because they can be self-administered. They wouldn’t need a nurse or clinical settings,” Swedish professor emeritus of epidemiology Marcello Ferrada de Noli explained to RT. As a result, he says, there’s hope that fewer people will be reluctant to be immunized. Not so many of us find it pleasant to get a jab – and after all, there are those who are just afraid of needles. Also, it would be much easier to vaccinate children with nasal substances.
However, what concerns Prof. de Noli the most is the duration of the effect of a vaccine of this type. Still, scientists can’t say for sure whether a nasal substance may completely replace a shot. According to Alexander Gintsburg, the head of Moscow’s Gamaleya Center biomedical research institute, which created the Sputnik V vaccine, the nasal version they are working on would serve for an additional protection against the virus, but would not replace the injections.
Chew the virus away?
A nasal vaccine is not the only one being developed. In summer, it was revealed that Russian Defense Ministry scientists were creating a ‘chewing gum’ vaccine, also targeting the mucosal immune response. Meanwhile, a UK firm announced this month that it would conduct a human trial of a skin patch that uses T-cells to confront the virus. Developers hope it would offer longer-lasting immunity than the existing vaccines. Work on a similar project is being done in the University of Queensland, Australia.
While it all looks so promising, Prof. de Noli warns that it would still take a lot of time until these products become available to the public. “I think that discoveries in this field are a very good thing. But if we say ‘We discovered a new type of vaccine’, people will say ‘Aha, so I’m going to wait’. But we need to vaccinate people now,” he points out.
Improving Covid treatment
Vaccines are not a silver bullet, unfortunately, given the not-so-high level of global immunization and the constantly emerging new strains of the virus. “People might get infected despite having had a vaccine, but I still think the vaccine strategy is going to be central to how we manage this kind of virus going forward,” Prof. Dockrell says. “But we will have other strategies that will be very important. We will have other elements. When we put them all together, it gives us the best opportunity that people can live with coronaviruses, and hopefully, the mortality can be limited to much lower extense than what we’ve sadly seen in the last eighteen months.”
Monoclonal antibodies will be central to the ongoing vaccine strategy, Prof. Dockrell explains. These are the antibodies similar to those the body uses to fight the virus. They are produced in labs and given via infusion or injection to boost the patient’s response against certain diseases. Monoclonal antibody treatment is used for people under a high risk of developing severe infection (including older patients 65+ years old or those with chronic medical conditions). It’s already being used in the US, following last year’s FDA approval. Earlier in November, the European Medicines agency recommended authorizing two monoclonal antibody medicines.
In October, UK’s AstraZeneca reported positive results of a Phase 3 study of its antibody combination, which, according to developers, is highly effective in both prevention and treatment of coronavirus.
Researchers are also working on a possibility to save Covid-infected patients from the so-called ‘cytokine storm’ – a situation when the immune system reacts so intensely that kills not only the virus, but the whole organism itself. A drug to ‘calm the storm’ was registered in Russia this year, and it’s already being used on patients.
Another way to fight Covid-19 is to use antiviral drugs. When the pandemic started, medics had to use something already existing (like anti-influenza Favipiravir) or something being authorized for emergency use (like remdesivir). Now, more than a year on, the work to create a special drug to specifically cure Covid-19 is giving its results. This month, Russia registered its first injectable anti-Covid medicine. A bit earlier, the UK became the first country to approve an antiviral pill produced by the US-based companies Merck and Ridgeback Biotherapeutics. Another American firm, Pfizer, got positive results from trials of its drug of the same kind. Both firms hope that with a drug in the form of a pill it would be easier to treat people at home.
Appreciating all the efforts on the field of developing anti-Covid treatment, Prof. de Noli points out that still, the key issue now is to reduce the spreading of the virus. “The new medicines are developed for people who already got the disease,” he says.
But we need to prevent people from getting the infection, not let them get infected because we have some new medicine that can cure them.
The same idea is echoed by scientists all over the world quoted in plenty of articles dedicated to the medical gains: it’s great to have the treatment, but none of the drugs may substitute vaccination, as first and foremost, humanity has to adopt preventive measures and stop the pandemic.
Controversial agriculture laws that saw farmers across India protesting for over a year are going to be rolled back, Prime Minister Narendra Modi has unexpectedly announced.
“I want to tell the country that we have decided to repeal the three farm laws,” Modi said in a televised address on Friday, which local media described as “stunning.”
The Indian parliament will complete the constitutional process of repealing the agricultural legislation in late November, he added.
However, the PM again defended the divisive legislation, saying that the reform of the sector, which accounts for some 15% of India’s $2.7 trillion economy, was actually aimed at supporting the country’s small farmers.
Whatever I did was for farmers. What I am doing is for the country.
“Maybe something was lacking in our efforts, which is why we couldn’t convince some farmers about the laws,” Modi acknowledged.
The laws, which were introduced last September, allowed farmers to sell their crops outside of the government-regulated wholesale markets, in which they were guaranteed a minimum price.
The government argued that it would see them earning more, but growers feared that that move would, on the contrary, cause a drop in prices and make them hostages to large corporations.
Thousands of farmers joined the protests against what they called “black laws,” and some rallies turned violent. A year later, many demonstrators remain camped along roads outside the capital New Delhi.
And the farmers aren’t planning on going home just yet, with one of their leaders saying on Twitter: “We will wait for parliament to repeal the laws.”
Modi’s concession to the protesters may have been unexpected, but it comes several months ahead of elections in India’s most populous state of Uttar Pradesh, as well as two other northern states with large rural populations.
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American billionaire Bill Gates has claimed Covid-19 deaths and infections may drop below seasonal flu levels next year as more people get vaccinated and treatment improves, unless we encounter a new, more deadly variant.
Speaking on Thursday in a virtual interview at the Bloomberg New Economy Forum in Singapore, founder of Microsoft stated that vaccines, natural immunity and emerging oral treatments mean that “the death rate and the disease rate ought to be coming down pretty dramatically.”
The tech mogul, who has been particularly vocal during the pandemic, said issues around vaccine-production capacity are likely to be replaced by distribution challenges and even waning demand.
“The vaccines are very good news, and the supply constraints will be largely solved as we get out in the middle of next year, and so we’ll be limited by the logistics and the demand,” he noted.
He also told his audience that it remains to be seen how much demand there is for Covid-19 shots in places like Sub-Saharan Africa.
Calling for more work to eradicate flu, Gates claimed Covid-19 rates and deaths would possibly fall below those of flu by the middle of next year, unless more deadly coronavirus variants emerge.
The Bill and Melinda Gates Foundation has involved itself in the development of vaccines and virus surveillance, calling for a global response to the Covid-19 pandemic. The foundation has invested hundreds of millions dollars in the development and distribution of potentially lifesaving shots.
According to the World Health Organization, influenza kills up to 650,000 people each year. At least five million people have died from Covid-19 since the pandemic began in late 2019.
Nadya Zafira, an international relations student at Indonesia’s Gadjah Mada University, won a writing competition for her letter to UN chief António Guterres, in which she addressed the inequalities laid bare by the COVID-19 pandemic, and how indigenous communities and youth are marginalized in global conversations on climate crisis.
Despite COVID-19 lockdowns and restrictions, some 650,000 women and girls were provided with gender-based violence services through a joint UN and European Union (EU) programme working to stamp out what is arguably one of the most prevalent human rights violations.
France’s education minister has announced plans to boost the teaching of ancient Greek and Latin in an effort to fight the proliferation of wokeism and “develop the culture” of the country’s younger generations.
Speaking on Monday, Education Minister Jean-Michel Blanquer, a leading figure in France’s war on woke, said that ancient Greek and Latin would become available to sixth formers pursuing vocational courses next year, as well as middle school students.
Blanquer wants sixth formers to have the opportunity to “develop their culture” by reading ancient philosophers while gaining the technical qualifications that the economy demands.
Speaking at a charter signing, alongside counterparts from Italy, Greece, and Cyprus, the minister claimed their joint commitment to the promotion of the classics came at a time when ancient languages were being threatened by American wokeism.
The targeting of the dead languages has been most prominent in the US with Princeton University announcing this summer that it would no longer require classics students to study ancient Greek and Latin; the two vernaculars are often considered the core pillars of the discipline.
Dan-el Padilla Peralta, an associate professor of classics at Princeton, claimed the ancient languages had been used as a justification of slavery, colonialism, and fascism for 2,000 years.
In a similar move, a Massachusetts high school boasted that it had removed Homer’s Odyssey from the school curriculum as it conflicted with the anti-racist agenda it wanted to teach. “Very proud to say we got the Odyssey removed from the curriculum this year,” a teacher wrote on social media.
Blanquer told Le Point that such interpretations of the classics were “completely mind boggling.” “To stick categories and a contemporary world view on writings dating back two millennia is an abyssal absurdity,” he added, noting that these civilizations brought us “openness and a search for the universal.”
The minister believes that ancient languages are a common bond for contemporary European nations, noting that the “common linguistic fund” would help spread “common values.”
Blanquer also claimed the classics respond to a demand for logos (language as a tool for reason), in a world where “a lack of reason is spreading like wildfire.”
Last month, the education minister set up a think tank dedicated to President Emmanuel Macron’s war on wokeism.
The liberal or woke agenda, which some in France claim is an Anglo-Saxon import, is likely to be a major feature in the 2022 presidential election, where Macron’s main competitor is likely to hail from the far right of the political spectrum.
At least two people were wounded by police gunfire in the Dutch city of Rotterdam after a protest over renewed Covid-19 restrictions spiraled into a violent riot, seeing demonstrators torch a squad car and clash with officers.
A large crowd of protesters showed up at Rotterdam’s iconic Coolsingel street on Friday evening to denounce a new round of pandemic measures, including an ongoing partial lockdown, a ban on New Year’s Eve fireworks displays, as well as fears the government will impose a ‘2G’ pass system allowing only the vaccinated and those who’ve recently recovered from the virus to enter a long list of public places.
At least two people were wounded during the demonstration, a local police spokesperson told Reuters, adding the injuries were “probably” due to officers’ “warning shots” but also noting that “direct shots were fired because the situation was life-threatening” to law enforcement.
Footage of the heated protest circulated online, some clips showing a police squad car fully engulfed in flames after it was apparently torched by rioters.
🇳🇱 Pays-Bas : Des émeutes sont en cours à #Rotterdam en marge d’une manifestation contre les restrictions sanitaires.
Demonstrators were also seen launching fireworks at police, who appeared to respond with large quantities of tear gas, which at one point blanketed the area.
Local law enforcement said that officers deployed a mobile riot control unit to Coolsingel and unleashed water cannon on protesters who refused to clear the streets, also noting that some arrests were made after an emergency order was imposed to cordon off the area.
The Dutch government announced the fireworks ban earlier on Friday, saying it is meant to “prevent, as much as possible, extra strain on healthcare, law enforcement and first responders.” However, while private displays are prohibited, officials said that local governments may still put on fireworks shows so long as their Covid-19 restrictions allow it.
The Netherlands currently has a ‘3G’ rule in place, allowing the vaccinated, the recently recovered, as well as those who test negative for the virus to enter most public spaces. But as the country remains under a partial three-week lockdown to rein in growing infections, officials are now mulling the stricter ‘2G’ scheme, prompting the intense demonstrations seen on Friday night.
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Hard-line cleric Ebrahim Raisi won Iran’s presidential election on Saturday in a move that is expected to bolster the conservative legacy of the country’s supreme leader, Ayatollah Ali Khamenei.
The decision is not expected to derail ongoing negotiations aimed at restoring the Joint Comprehensive Plan of Action (JCPOA) nuclear deal, even though Mr. Raisi himself is under US sanctions over accusations of human rights abuses. Many voters stayed away from the polls as the outcome had been predicted for months with many progressive candidates barred from running.
“The Islamic Republic has entered a post-revolutionary dynamic in which a fading revolutionary generation seeks to ensure that the rising political leadership sustains their revolutionary ideals,” says Norman T. Roule, former National Intelligence Manager for Iran at ODNI and Cipher Brief Expert. “The regime’s decision to bar so many candidates and the low turnout make this election a historic embarrassment for the regime and its supporters.”
The Cipher Brief talked with Roule about what the election means and what it doesn’t mean when it comes to relations with the west, the progressive movement within Iran and the election’s impact on the oil markets.
“The Cipher Brief has become the most popular outlet for former intelligence officers; no media outlet is even a close second to The Cipher Brief in terms of the number of articles published by formers.” – Sept. 2018, Studies in Intelligence, Vol. 62 No.
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Japan’s fifth wave of Covid-19 has virtually disappeared so dramatically that some scientists are puzzled as to why it happened. One team suggests the highly infectious Delta strain mutated into extinction on the island nation.
In mid-August, Japan experienced a peak in Covid-19 infections, recording over 23,000 new cases per day. Now the metric is just around 170, with deaths attributed to the disease mostly remaining in single digits this month.
The decline has been attributed by many to high vaccination rates, public acceptance of masks, and other factors, but some researchers say the drop was uniquely significant, compared to other nations with similar conditions.
Ituro Inoue, a geneticist at the National Institute of Genetics, believes that Japan had the good fortune of witnessing the Delta strain mostly rooting out other variants of the SARS-CoV-2 virus before then eradicating itself. He explained his team’s theory to the Japan Times newspaper this week.
For some time now, Inoue and his fellow scientists were researching mutations of SARS-CoV-2 and how they are affected by the protein nsp14, which is crucial for the reproduction of the virus.
RNA viruses, like the one causing Covid-19, tend to have a very high mutation rate, which helps them quickly adapt to changes in the environment. However, this opens the door for a so-called “error catastrophe,” when bad mutations pile up and finally cause the full extinction of a strain. The protein nsp14 appears to offer a form of error proofreading that helps the virus genome to stay below the threshold of the “error catastrophe.”
In the case of Japan’s fifth wave of Covid-19, the Delta variant’s nsp14 failed at this job, Inoue believes, based on the genetic study of specimens collected from June to October. Contrary to his team’s expectations, there was a lack of genetic diversity, while many samples had many genetic changes in the site called A394V, which is linked to the error-fixing protein.
“We were literally shocked to see the findings,” the researcher told the Japan Times. “The Delta variant in Japan was highly transmissible and [was] keeping other variants out. But as the mutations piled up, we believe it eventually became a faulty virus and it was unable to make copies of itself.”
The theory could be relevant to the previous SARS strain, which was identified in 2003, explaining why it didn’t cause a pandemic. But that would be hard to confirm, since the outbreak ended relatively quickly and didn’t result in the massive collection of genetic data necessary to test the hypothesis.
It’s not clear why Japan had this lucky turn of events, but nothing comparable happened in other East Asian countries like South Korea, where populations are genetically close to that of Japan. Virus mutations similar to those flagged by the scientists have been discovered in at least 24 countries, Inoue said. He and his team plan to publish a paper detailing their findings by the end of November.
Even if the natural extinction theory is confirmed, it is at best a temporary reprieve for the Japanese people. New, more successful strains are likely to eventually find their way into the country, though quarantine measures and immigration control could delay the emergence of new variants in Japan, Inoue believes.
Meanwhile, Tokyo is bracing for a new wave of Covid-19 this winter and is preparing to live with the virus. The government reportedly plans to ease travel restrictions by increasing the number of people it allows to enter the country per day from 3,500 to 5,000.
French luxury giant Dior has taken down a controversial photograph that had been criticized in China for “smearing Asian women” by pandering to Western stereotypes while “distorting Chinese culture.”
The photo, which was part of the brand’s ‘Lady Dior’ exhibition in Shanghai, depicts an Asian model wearing a traditional dress and clutching a Dior handbag. It came under fire this week from Chinese media outlets for featuring “spooky eyes, [a] gloomy face and Qing Dynasty-styled nail armor.”
Although Dior has not released a statement regarding the controversy, it confirmed to fashion trade publication Business of Fashion that the photo had been removed from the exhibition. The brand has also reportedly taken the photo off Chinese social media platform Weibo.
The image, which was shot by Chinese photographer Chen Man, had drawn both media ire and public outrage. However, there were apparently no calls for a boycott of the brand.
In an editorial on Monday titled “Is This the Asian Woman in Dior’s Eyes?”, the Beijing Daily paper had noted that the image makes Chinese consumers uncomfortable. The publication criticized Man for “playing up to the brands, or the aesthetic tastes of the Western world.”
For years, Asian women have always appeared with small eyes and freckles from the Western perspective, but the Chinese way to appreciate art and beauty can’t be distorted by that.
Warning that both the brand and the photographer had “gone too far,” the China Women’s News paper ran an editorial on Wednesday that claimed it “indicated their intention of uglifying Chinese women and distorting Chinese culture.”
“Again, from… Dior’s ghost-style picture, which makes the public feel uncomfortable, it’s easy to see some Western brands’ ‘pride and prejudice’ in their aesthetics and culture,” said the newspaper, which is run by the All-China Women’s Federation.
Meanwhile, the Global Times noted that the “lingering controversy could pose a delicate situation” for Dior and other global brands – for whom China’s “massive” luxury market was one of the biggest sources of revenue. The paper said that the Chinese public had become “increasingly sensitive” toward the depiction and treatment of Chinese people and culture by foreign companies.
While pointing out that Chinese social media users had demanded the company and photographer explain their intention, a number of media outlets also highlighted how some netizens had praised the photo as a departure from typical standards of beauty in the country, often characterized by “fair skin and large eyes.”
