An Argentinian woman has become the second-ever HIV-infected person whose immune system helped defeat the virus without requiring additional medical treatment. She was first diagnosed with the AIDS-causing infection in 2013.
Scientists have dubbed the 30-year-old mother the “Esperanza patient,” after her hometown. The word ‘esperanza’ translates to ‘hope’ in English. Publishing their findings in the Annals of Internal Medicine journal on Monday, the researchers said the discovery boosts hope for a “sterilizing cure” for the estimated 38 million people with the life-long infection.
“I enjoy being healthy,” the Esperanza patient told NBC News over email. “I have a healthy family. I don’t have to medicate, and I live as though nothing has happened. This already is a privilege.”
The study found no intact remnants of the virus in the 1.5 billion blood and tissue cells the researchers analyzed – confirming the discovery first announced in March at an international meeting of HIV experts.
No additional information about the woman has been made public, but she was described at the time as “athletic and beautiful” and revealed to have an HIV-negative boyfriend and newborn baby.
Only one other person, identified in August 2020 as 67-year-old Loreen Willenberg from San Francisco, has been confirmed to have overcome the virus without medical intervention. The two women have been labeled ‘elite controllers’, referring to a rare subset of HIV patients who show no signs of the infection despite not undergoing antiretroviral treatments.
Typically, an HIV-infected person requires constant drug therapy to prevent the virus from attaching to their immune cells’ DNA and replicating. But, in the eight years since she was diagnosed, the Esperanza patient only received medication for six months during pregnancy to ensure her baby would be healthy.
In all, there have been four patients cured of HIV, two of whom – the ‘Berlin patient’ Timothy Ray Brown and the ‘London patient’ Adam Castillejo – were also cancer patients who received risky bone marrow transplants from donors with HIV-resistant genes. However, the success of their procedures is yet to be replicated.
“This is really the miracle of the human immune system that did it,” Dr. Xu Yu, an immunologist at the Ragon Institute in Boston, who co-authored the study, told NBC.
A stream literally flowing with booze emitting a strong beery odor has been discovered in one of the tropical islands of Hawaii. Its waters have been apparently contaminated with alcohol after a leak at a beverage warehouse.
A small river with a distinctive alcoholic smell was recently found on the island of Oahu, some 15 miles (24 kilometers) away from Honolulu, Hawaiian capital. Its waters have been flowing through the Waipio valley and even turned into a 100-foot (30 meters) waterfall on their way.
The stream caught the attention of local environmental activists, who noticed the smell in the area.
“The other day we came here you would think it was a beer pub that hadn’t opened its doors for three or four days,” activist Carroll Cox told local Hawaii News Now. She also contacted the Department of Health about the issue.
Local media took samples from the unusual stream and had them checked at a private laboratory. It tested positive for alcohol, containing 1.2% percent of the substance in its waters – nearly a quarter the content in regular beer and strong enough to cause a buzz.
Local health authorities got involved, and an investigation into the source of contamination was launched. It was learned that the stream was coming from a drain pipe that was traced back to a warehouse of Hawaii’s largest liquor distributor, Paradise Beverages. Its representatives told local media they were working with officials to eliminate a possible spill, with the booze river apparently closing its free drinks service.
Brazil’s former President Luiz Inacio Lula da Silva has said he is willing to stand as a candidate in elections against incumbent leader Jair Bolsonaro, labelling his potential opponent “a poor copy of Trump.”
Speaking in Brussels at a media conference in the European Parliament on Monday, Lula announced that the Workers Party needs to put forward a presidential candidate to take over from right-wing Bolsonaro in 2022 and said he was willing to run in the elections again.
“I’m willing, I’m motivated, I’m in good health,” Lula stated, adding that said he would only make his decision early next year, some months before the election scheduled for October 2022. The popular leftist said his candidacy would depend on whether the party wanted him.
“We need to have someone who stands, we need to win the elections. And at the same time, we have to rebuild Brazil,” he said, speaking on behalf of his Workers Party.
Lula, 76, also took aim at the incumbent president. “He’s a poor copy of Trump. But Bolsonaro doesn’t think, he doesn’t have any ideas,” the former president said, claiming the incumbent leader was hellbent on ensuring the beneficial legacies of Lula’s administration were “torn down.”
A recent poll put him 27 points ahead of Bolsonaro, despite his candidacy not officially being announced.
In 2010, Lula made way for his protégé, Dilma Rousseff. Rousseff was ousted from power in what was described by her supporters as a parliamentary coup. Lula served nearly two years in prison after being convicted on money laundering and corruption, despite a nine-and-a-half-year sentence. He was also barred from running in the 2018 election.
A number of judges have subsequently ruled that the case against Lula was unlawful and the Supreme Court annulled his earlier convictions, meaning he can face off against Bolsonaro in 2022.
The Islamic State terrorist group is tearing a path across Afghanistan, establishing itself in “nearly all” of its provinces while increasing attacks more than five-fold in the past year, the UN’s envoy to the country has warned.
Addressing the UN Security Council on Wednesday, the body’s special representative for Afghanistan Deborah Lyons spoke of a major Islamic State (IS, formerly ISIS) surge through the war-torn country, claiming the jihadist group has now expanded nationwide.
“Once limited to a few provinces and the capital, ISKP now seems to be present in nearly all provinces, and increasingly active,” Lyons said, referring to the group’s Afghanistan-based ‘Khorasan’ faction. She added that so far in 2021, IS has carried out 334 attacks, up from just 60 last year.
The envoy’s comments came just hours after an Islamic State bombing erupted in a Shiite Muslim neighborhood of the Afghan capital, killing one and wounding six others, according to Reuters.
Since taking over as the government following a chaotic US withdrawal and the outright collapse of the American-backed administration in Kabul last summer, the Taliban has struggled to keep the terrorist group at bay, Lyons said. Though she noted that the Taliban insists it is “waging a concerted campaign” against IS and is making “genuine efforts to present itself as a government,” she said its response “appears to rely heavily on extrajudicial detentions and killings.”
Despite the rise in IS attacks in recent months, however, Lyons said the overall security situation in Afghanistan has improved since the end of the US war, which stretched on for two decades.
In addition to the terrorism issue, the UN representative also cited broader concerns for the country in the coming months, warning of a looming “humanitarian catastrophe” driven by a litany of causes, including foreign sanctions – which she said have “paralyzed” the local banking system – as well as growing levels of food shortages due to famine and a failing economy, among other factors.
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Rotterdam Mayor Ahmed Aboutaleb has described an anti-lockdown protest in his city as an “orgy of violence.” The Dutch demonstration devolved into a violent riot that saw police open fire on protesters.
Aboutaleb described the events of Friday night as an “orgy of violence,” after protesters packed Rotterdam’s central Coolsingel shopping street to voice their opposition to an ongoing partial lockdown, a ban on New Year’s Eve fireworks displays, and the possibility of a two-tiered system of freedom in the Netherlands, one of liberty for the vaccinated and restrictions for those without the jab.
The protest soon got out of hand, and police said on Saturday that 57 people were arrested. Protesters were seen torching police vehicles and launching fireworks at police, who shot at them in response.
Aboutaleb said that the cops had been “forced” to use their weapons. “On a number of occasions the police felt it necessary to draw their weapons to defend themselves,” he told reporters. “They shot at protesters, people were injured.”
Police say at least seven people were injured. Two of these injuries were caused by police bullets, and the victims are still in hospital. One officer was hospitalized, while several others were treated at the scene for minor injuries.
Covid-19 variants keep emerging in different parts of the world, causing experts to ask how long the pandemic will last, and how effective the current methods of protection really are.
Since the pandemic started in 2019, people have referred to the disease which has paralyzed the world simply as ‘coronavirus’. Now, in 2021, when we talk about it, we mean not just the original variant, but also its numerous mutations.
In May, the WHO decided to label the key variants with Greek letters. Since then, the Delta variant has been proclaimed the predominant strain across the world, and now we have titles that look like codes to detail the differences between variants. Last month, the UK was put on high alert over a fast-spreading Delta AY.4.2 variant. This week, Norway reported finding one more version of the Delta strain – AY. 63. The country’s experts suggest it’s not more dangerous than the Delta mutation itself. Meanwhile, another Covid variant, discovered in France (B.1.640), brought the researchers an unpleasant surprise: they said they’d never seen mutations like it.
Professor David Dockrell, from the Center for Inflammation Research of the University of Edinburgh, described to RT the reasons for the constant mutation of the coronavirus. “The areas in the virus that are most likely to change are those that come into contact with what we call ‘selective pressures’ – or factors that make them need to change,” he explains. “So, a version of the virus which mutates and changes to give it a selective advantage to escape from the immune system is more likely to prosper and become a dominant strain.”
That’s how it works: The part of the virus many of the immune responses (or antibodies, T-cells etc.) are responding to is called the spike protein (or the S-protein). So, the virus tries to change it in order to survive.
“We know that a variety of different viruses are able to mutate and change when exposed to the selective pressure of the immune system, whether it would be the human immune system or other species in which these viruses have evolved,” Prof. Dockrell says. “And of course, we’ve seen it most clearly with HIV, which is particularly good at changing and evolving. It does something called ‘reverse transcription’ – it copies material in the reversed direction from DNA to RNA.”
Covid is still seemingly running faster than humanity’s efforts to curb it, but Prof. Dockrell has some good news. “The coronavirus – and viruses like it – are not as able to make these changes. They are going to do it to some extent, but they are not going to be as successful as retroviruses and HIV.”
And the other major thing to say: When the viruses make changes, there’s always what we call ‘a fitness cost’. Many of the potential changes that the virus could make will actually not favor its survival. So there are only a certain number, potentially, of changes that the virus can make, before it starts affecting its fitness.
Now, unfortunately, we are still in a phase where Covid19 can continue to evolve and change. It’s not time to panic, though, because across the world various ways to adapt the current anti-Covid strategies are already in place. First of all, people should keep getting vaccines – maybe receiving slightly altered booster doses, Prof. Dockrell suggests, “in a way, that we, after all, have to do with influenza, by providing a seasonal influenza vaccine and changing it every year.”
“And maybe we have to keep changing some of the treatments like these new monoclonal antibodies against the virus, because they also may be limited by the emergence of a mutation of the virus evolving the S-protein,” he adds.
Sounds promising – but won’t it become a never-ending race against constantly emerging mutations?
Hopefully not. According to Prof. Dockrell, there are parts of viruses that scientists call ‘conserved areas’. With time, vaccines and monoclonal antibodies will target these areas, which the virus finds very hard to change. “Clearly, the direction of travel is to develop either vaccine responses that affect more different kinds of virus, or these ‘monoclonal antibodies’ that we could use to prevent or treat infection, that they will target more conserved areas and therefore will be less limited by the ability of these virus to evolve and change,” he concludes.
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Truckers and other motorists have been trapped in a four-mile-long traffic jam on the outskirts of the Dutch city of Rotterdam amid a protest against the government’s Covid measures.
According to local media, as many as 200 activists blocked the gates of a major port in the city’s harbor on Thursday. For several hours, they prevented any vehicles from driving in and out of the cargo hub, which, in turn, led to massive traffic congestion on the highway leading to the port. Police engaged in negotiations with the protesters, who eventually relented and left the site later in the evening.
The group behind the protest action is reportedly Dockers United, who are staunchly opposed to government Covid policies. The organization’s biggest concern is that authorities could soon make it mandatory for employees to have a vaccination or recovery certificate to enter the workplace, which, as the group argues, would be tantamount to excluding people from society on an “unconstitutional basis.” They are also generally unhappy with the curbs introduced by the Dutch government, with ‘Don’t normalize what’s not normal’ being a translation of one of their slogans.
In fact, the Dutch government did announce earlier this month that it was working on introducing a ‘corona pass’ for the workplace, though it isn’t clear yet when this measure will be rolled out and how strict it will be.
Meanwhile, on Friday the EU country logged its highest-ever number of new Covid cases within 24 hours, with that figure reaching 23,591. Medics say they are working at capacity.
Amid the spike, the Dutch prime minister imposed a partial lockdown last Saturday, which requires bars, restaurants, cafes and supermarkets to close at 8pm, while shops selling non-essential goods are to shut by 6pm. Public gatherings are banned altogether.
Clinics in the Austrian region of Salzburg have set up a special assessment team tasked with identifying Covid patients who have a higher chance of survival; the rest may soon have to take a back seat.
Amid a dramatic spike in Covid cases, medical personnel warn they may soon have to make the heart-wrenching choice of which patients get life-saving treatment and which ones will have to wait, Austrian media report. Intensive care units in the Salzburg region are packed, with the number of patients treated there setting a new grim record on Tuesday, reaching 33. The region ranks amid Austria’s hardest-hit, logging more than 1,500 new infections per 100,000 residents in a week. In an emotional plea for help to the local government, the head of Salzburg’s hospitals warned that soon clinics would likely not be able to guarantee the existing level of standards in terms of medical treatment. A representative for the city clinics likened the situation to “running into a wall.”
The region’s governor, Wilfried Haslauer, announced on Tuesday that some of the Covid patients whose condition was no longer life-threatening would be transferred from hospitals to rehabilitation centers to make room for more serious cases.
In neighboring Upper Austria, the situation is no better, with the number of deaths in intensive care units surpassing figures seen in all the previous Covid waves. Speaking to Austria’s Der Standard paper on condition of anonymity, healthcare workers there said they had free beds “because the infected are dying.”
For the time being, the creation of a so-called ‘triage team’ in Salzburg hospitals is being described as a “precautionary measure.” The panel is made up of six people: one legal expert and five providers from various medical disciplines. If push comes to shove, they will be deciding which patients stand a chance and which treatments have little prospect of success.
