Japan’s fifth wave of Covid-19 has virtually disappeared so dramatically that some scientists are puzzled as to why it happened. One team suggests the highly infectious Delta strain mutated into extinction on the island nation.
In mid-August, Japan experienced a peak in Covid-19 infections, recording over 23,000 new cases per day. Now the metric is just around 170, with deaths attributed to the disease mostly remaining in single digits this month.
The decline has been attributed by many to high vaccination rates, public acceptance of masks, and other factors, but some researchers say the drop was uniquely significant, compared to other nations with similar conditions.
Ituro Inoue, a geneticist at the National Institute of Genetics, believes that Japan had the good fortune of witnessing the Delta strain mostly rooting out other variants of the SARS-CoV-2 virus before then eradicating itself. He explained his team’s theory to the Japan Times newspaper this week.
For some time now, Inoue and his fellow scientists were researching mutations of SARS-CoV-2 and how they are affected by the protein nsp14, which is crucial for the reproduction of the virus.
RNA viruses, like the one causing Covid-19, tend to have a very high mutation rate, which helps them quickly adapt to changes in the environment. However, this opens the door for a so-called “error catastrophe,” when bad mutations pile up and finally cause the full extinction of a strain. The protein nsp14 appears to offer a form of error proofreading that helps the virus genome to stay below the threshold of the “error catastrophe.”
In the case of Japan’s fifth wave of Covid-19, the Delta variant’s nsp14 failed at this job, Inoue believes, based on the genetic study of specimens collected from June to October. Contrary to his team’s expectations, there was a lack of genetic diversity, while many samples had many genetic changes in the site called A394V, which is linked to the error-fixing protein.
“We were literally shocked to see the findings,” the researcher told the Japan Times. “The Delta variant in Japan was highly transmissible and [was] keeping other variants out. But as the mutations piled up, we believe it eventually became a faulty virus and it was unable to make copies of itself.”
The theory could be relevant to the previous SARS strain, which was identified in 2003, explaining why it didn’t cause a pandemic. But that would be hard to confirm, since the outbreak ended relatively quickly and didn’t result in the massive collection of genetic data necessary to test the hypothesis.
It’s not clear why Japan had this lucky turn of events, but nothing comparable happened in other East Asian countries like South Korea, where populations are genetically close to that of Japan. Virus mutations similar to those flagged by the scientists have been discovered in at least 24 countries, Inoue said. He and his team plan to publish a paper detailing their findings by the end of November.
Even if the natural extinction theory is confirmed, it is at best a temporary reprieve for the Japanese people. New, more successful strains are likely to eventually find their way into the country, though quarantine measures and immigration control could delay the emergence of new variants in Japan, Inoue believes.
Meanwhile, Tokyo is bracing for a new wave of Covid-19 this winter and is preparing to live with the virus. The government reportedly plans to ease travel restrictions by increasing the number of people it allows to enter the country per day from 3,500 to 5,000.
Palestinian Islamist group Hamas has called on Canadian singer Justin Bieber to cancel his upcoming concert in what it calls the “Zionist occupation state” of Israel.
Bieber announced his 2022 world tour dates this week, with a concert in Tel Aviv planned for next October. On Thursday, Hamas’ Artistic Production Department issued a statement, cited by the Palestinian Sawa news outlet, “condemning and denouncing” the performer. It called on the star to cancel the show and “boycott the Zionist occupation state in protest at its repeated crimes against the Palestinian people.”
Bieber has performed in Israel multiple times, his last performance there having been in 2017 at Park HaYarkon – the same venue slated for next year. Since the announcement of the ‘Justice’ tour dates, calls for him to cancel the Tel Aviv show have gained momentum across social media, with many posters condemning the singer for supporting what one called an “apartheid state.”
Some noted that Bieber was set to arrive in Israel after performing in South Africa. “Justin Bieber is really going straight from SA to Israel. From a country that fought apartheid to a country that’s practicing apartheid,” one Twitter user complained.
A petition asking the singer to boycott Israel and exclude it from his tour has been launched online, and had garnered some 3,700 signatures by Friday.
In 2018, the New Zealand singer Lorde canceled a concert in Israel, subsequently thanking fans for “educating” her on the issue, and, the same year, US artist Lana Del Rey at first defended her decision to perform in the country, saying her appearance would not be a “political statement,” before backtracking and canceling the gig.
Hamas has been designated a terrorist group by the US, the EU, and, as of Friday, the UK. In April 2021, international non-governmental organization Human Rights Watch concluded in a report that Israel had committed “crimes against humanity of apartheid and persecution.”
Australia’s government could be forced to spend tens of millions in payouts after receiving more than 10,000 compensation claims from people who suffered side effects and loss of income due to Covid-19 vaccines.
Under its no-fault indemnity scheme, eligible claimants can apply for compensation amounts between AU$5,000 (US$3,646) to AU$20,000 (US$14,585) to cover medical costs and lost wages as a result of being hospitalized after getting the shot. The scheme’s online portal is scheduled to be launched next month.
Official figures suggest, however, that over 10,000 people have already indicated their intention to make a claim since registration opened on the health department’s website in September. If each claim was approved, the government could face a bill of at least AU$50 million (US$36.46 million).
There were around 78,880 adverse events to Covid-related vaccination in Australia as of November 7, according to the Therapeutic Goods Administration, which regulates national health products. The majority of side effects were minor, including headaches, nausea, and arm soreness.
Only people who experienced a moderate to significant adverse reaction that resulted in a hospital stay of at least one night are eligible for coverage under the government’s scheme. Those seeking $20,000 or less have to provide proof their claims are vaccine-related – although there has been no information as yet on exactly what evidence would be acceptable.
“Adverse events, even though they happen to a tiny proportion of people, for the people it does impact it’s really quite devastating,” Clare Eves, the head of medical negligence at injury compensation firm Shine Lawyers, told the Sydney Morning Herald.
Among the adverse reactions covered are the blood clotting disorder “thrombosis with thrombocytopenia syndrome (TTS)” linked to the AstraZeneca vaccine and the “myocarditis and pericarditis” heart conditions associated with the Pfizer vaccine. Other reportedly accepted side effects are Guillain-Barré syndrome, a rare neurological condition, and immune thrombocytopenia (excessive bleeding due to low platelet levels).
Claims for over $20,000, including those for vaccine-related deaths, will be assessed by an independent legal panel of legal experts and compensation paid on its recommendations. Nine people have reportedly died after an adverse reaction to one of the three vaccines in the country.
Eves told the Morning Herald that her firm was representing a number of litigants over the vaccine side effects, including several who are not eligible for the scheme.
